Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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L329314-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $118.90 | |
L329314-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $406.90 | |
L329314-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,463.90 |
a water soluble, broad spectrum antibiotic with activity against anaerobic bacteria and protozoans
Synonyms | lincomycin | 154-21-2 | Lincolnensin | Cillimycin | Lincomycinum | Jiemycin | Lincomicina | Lincomycin A | Lincomycine | Bactramycin | Lincorex | Lincomycin (USAN/INN) | UNII-BOD072YW0F | BOD072YW0F | CHEMBL1447 | Lincolcina | CHEBI:6472 | U-10149 | HSDB 3109 | U 10,149A | EINECS 205-824-6 | Linc |
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Specifications & Purity | Moligand™, ≥98% |
Source | Streptomycessp. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Bacterial 70S ribosome inhibitor |
Product Description | Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from|Streptomyces licolnensis|by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N- methylproline, coupled to an equally rare aminomethylthio- octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations. |
pKa | pKₐ: 12.91 (Predicted), pKₐ: 8.78 (Predicted) |
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ALogP | 0.2 |
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IUPAC Name | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide |
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INCHI | InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1 |
InChi Key | OJMMVQQUTAEWLP-KIDUDLJLSA-N |
Canonical SMILES | CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O |
Isomeric SMILES | CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O |
RTECS | RH6314000 |
Alternate CAS | 7179-49-9 |
PubChem CID | 3000540 |
Molecular Weight | 406.54 |
Beilstein | 707677 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2414134 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414135 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414136 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414137 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414138 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414139 | Certificate of Analysis | Mar 11, 2024 | L329314 |
Solubility | Soluble in ethanol, methanol, DMF, DMSO, and water. |
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Sensitivity | Moisture sensitive |
Refractive Index | n20D1.58 (Predicted) |
Boil Point(°C) | ~646.8° C at 760 mmHg (Predicted) |
Melt Point(°C) | 262.24° C (Predicted) |
RTECS | RH6314000 |
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1. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, 872 (162279). [PMID:36801336] |
2. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] |
3. Tingting Liu, Xiaocui Lai, Ping Guo, Wei Zhang, Gan Zhang, Mengyun Wu, Guangjian Xue, Xuechen Fang, Juan Peng, Weihua Lai. (2023) Sensitive lateral flow immunoassay strips based on Fe3+-chelated polydopamine nanospheres for the detection of kanamycin. FOOD CHEMISTRY, 411 (135511). [PMID:36701914] |
4. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |
1. MACLEOD AJ, ROSS HB, OZERE RL, DIGOUT G, VAN ROOYENC. (1964) LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES.. Can Med Assoc J, 91 (3): (1056-60). [PMID:14217764] |
2. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, 872 (162279). [PMID:36801336] |
3. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] |
4. Tingting Liu, Xiaocui Lai, Ping Guo, Wei Zhang, Gan Zhang, Mengyun Wu, Guangjian Xue, Xuechen Fang, Juan Peng, Weihua Lai. (2023) Sensitive lateral flow immunoassay strips based on Fe3+-chelated polydopamine nanospheres for the detection of kanamycin. FOOD CHEMISTRY, 411 (135511). [PMID:36701914] |
5. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |