Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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L329314-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $118.90 | |
L329314-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $406.90 | |
L329314-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,463.90 |
a water soluble, broad spectrum antibiotic with activity against anaerobic bacteria and protozoans
Synonyms | methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside |
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Specifications & Purity | Moligand™, ≥98% |
Source | Streptomycessp. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Bacterial 70S ribosome inhibitor |
Product Description | Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from|Streptomyces licolnensis|by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N- methylproline, coupled to an equally rare aminomethylthio- octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations. |
pKa | pKₐ: 12.91 (Predicted), pKₐ: 8.78 (Predicted) |
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ALogP | 0.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide |
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INCHI | InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1 |
InChi Key | OJMMVQQUTAEWLP-KIDUDLJLSA-N |
Canonical SMILES | CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O |
Isomeric SMILES | CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O |
RTECS | RH6314000 |
Alternate CAS | 7179-49-9 |
PubChem CID | 3000540 |
Molecular Weight | 406.54 |
Beilstein | 707677 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2414134 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414135 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414136 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414137 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414138 | Certificate of Analysis | Mar 11, 2024 | L329314 |
H2414139 | Certificate of Analysis | Mar 11, 2024 | L329314 |
Solubility | Soluble in ethanol, methanol, DMF, DMSO, and water. |
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Sensitivity | Moisture sensitive |
Refractive Index | n20D1.58 (Predicted) |
Boil Point(°C) | ~646.8° C at 760 mmHg (Predicted) |
Melt Point(°C) | 262.24° C (Predicted) |
RTECS | RH6314000 |
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1. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, 872 (162279). [PMID:36801336] [10.1016/j.scitotenv.2023.162279] |
2. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] [10.3390/mi14020350] |
3. Tingting Liu, Xiaocui Lai, Ping Guo, Wei Zhang, Gan Zhang, Mengyun Wu, Guangjian Xue, Xuechen Fang, Juan Peng, Weihua Lai. (2023) Sensitive lateral flow immunoassay strips based on Fe3+-chelated polydopamine nanospheres for the detection of kanamycin. FOOD CHEMISTRY, 411 (135511). [PMID:36701914] [10.1016/j.foodchem.2023.135511] |
4. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
5. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 256 (119751). [PMID:33819765] [10.1016/j.saa.2021.119751] |
6. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
7. Tianyu Cui, Xiuping Li, Suyun He, Danhan Xu, Li Yin, Xiaoling Huang, Siwei Deng, Wanqing Yue, Wenying Zhong. (2020) Instant Self-Assembly Peptide Hydrogel Encapsulation with Fibrous Alginate by Microfluidics for Infected Wound Healing. ACS Biomaterials Science & Engineering, 6 (9): (5001–5011). [PMID:33455293] [10.1021/acsbiomaterials.0c00581] |
8. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [PMID:] [10.1016/j.snb.2019.126664] |
9. Zhou Yunlei, Sui Chengji, Yin Huanshun, Wang Yue, Wang Minghui, Ai Shiyun. (2018) Tungsten disulfide (WS2) nanosheet-based photoelectrochemical aptasensing of chloramphenicol. MICROCHIMICA ACTA, 185 (10): (1-8). [PMID:30209622] [10.1007/s00604-018-2970-8] |
10. Wang Hai-Bo, Li Yang, Bai Hong-Yu, Zhang Zi-Ping, Li Yong-Hong, Liu Yan-Ming. (2018) Development of Rapid and Label-Free Fluorescence Sensing of Tetracyclines in Milk Based on Poly(Adenine) DNA-Templated Au Nanoclusters. Food Analytical Methods, 11 (11): (3095-3102). [PMID:] [10.1007/s12161-018-1289-8] |
11. Chengji Sui, Yunlei Zhou, Mengying Wang, Huanshun Yin, Po Wang, Shiyun Ai. (2018) Aptamer-based photoelectrochemical biosensor for antibiotic detection using ferrocene modified DNA as both aptamer and electron donor. SENSORS AND ACTUATORS B-CHEMICAL, 266 (514). [PMID:] [10.1016/j.snb.2018.03.171] |
12. Yi Xiao, Linru Xu, Ping Li, Xiao-Chong Tang, Lian-Wen Qi. (2017) A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum. ANALYTICA CHIMICA ACTA, 983 (96). [PMID:28811034] [10.1016/j.aca.2017.06.014] |
13. Joel Isanga, Daniel Mukunzi, Yanni Chen, Steven Suryoprabowo, Liqiang Liu, Hua Kuang. (2017) Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs. FOOD AND AGRICULTURAL IMMUNOLOGY, 28 (4): (668-684). [PMID:] [10.1080/09540105.2017.1309361] |
14. Panpan Gai, Chengcheng Gu, Ting Hou, Feng Li. (2017) Ultrasensitive Self-Powered Aptasensor Based on Enzyme Biofuel Cell and DNA Bioconjugate: A Facile and Powerful Tool for Antibiotic Residue Detection. ANALYTICAL CHEMISTRY, 89 (3): (2163–2169). [PMID:28208296] [10.1021/acs.analchem.6b05109] |
1. MACLEOD AJ, ROSS HB, OZERE RL, DIGOUT G, VAN ROOYENC. (1964) LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES.. Can Med Assoc J, 91 (13): (1056-60). [PMID:14217764] [10.1021/op500134e] |
2. Junhua Chen, Gu Shi, Chong Yan. (2023) Portable biosensor for on-site detection of kanamycin in water samples based on CRISPR-Cas12a and an off-the-shelf glucometer. SCIENCE OF THE TOTAL ENVIRONMENT, 872 (162279). [PMID:36801336] [10.1016/j.scitotenv.2023.162279] |
3. Dan Liu, Jiahui Ji, Xinran Guo, Sanhu Gou, Xinyue Chen. (2023) Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles. Micromachines, 14 (2): (350). [PMID:36838050] [10.3390/mi14020350] |
4. Tingting Liu, Xiaocui Lai, Ping Guo, Wei Zhang, Gan Zhang, Mengyun Wu, Guangjian Xue, Xuechen Fang, Juan Peng, Weihua Lai. (2023) Sensitive lateral flow immunoassay strips based on Fe3+-chelated polydopamine nanospheres for the detection of kanamycin. FOOD CHEMISTRY, 411 (135511). [PMID:36701914] [10.1016/j.foodchem.2023.135511] |
5. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] [10.1016/j.mcpro.2022.100248] |
6. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 256 (119751). [PMID:33819765] [10.1016/j.saa.2021.119751] |
7. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 252 (119506). [PMID:33561684] [10.1016/j.saa.2021.119506] |
8. Tianyu Cui, Xiuping Li, Suyun He, Danhan Xu, Li Yin, Xiaoling Huang, Siwei Deng, Wanqing Yue, Wenying Zhong. (2020) Instant Self-Assembly Peptide Hydrogel Encapsulation with Fibrous Alginate by Microfluidics for Infected Wound Healing. ACS Biomaterials Science & Engineering, 6 (9): (5001–5011). [PMID:33455293] [10.1021/acsbiomaterials.0c00581] |
9. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, 296 (126664). [PMID:] [10.1016/j.snb.2019.126664] |
10. Zhou Yunlei, Sui Chengji, Yin Huanshun, Wang Yue, Wang Minghui, Ai Shiyun. (2018) Tungsten disulfide (WS2) nanosheet-based photoelectrochemical aptasensing of chloramphenicol. MICROCHIMICA ACTA, 185 (10): (1-8). [PMID:30209622] [10.1007/s00604-018-2970-8] |
11. Wang Hai-Bo, Li Yang, Bai Hong-Yu, Zhang Zi-Ping, Li Yong-Hong, Liu Yan-Ming. (2018) Development of Rapid and Label-Free Fluorescence Sensing of Tetracyclines in Milk Based on Poly(Adenine) DNA-Templated Au Nanoclusters. Food Analytical Methods, 11 (11): (3095-3102). [PMID:] [10.1007/s12161-018-1289-8] |
12. Chengji Sui, Yunlei Zhou, Mengying Wang, Huanshun Yin, Po Wang, Shiyun Ai. (2018) Aptamer-based photoelectrochemical biosensor for antibiotic detection using ferrocene modified DNA as both aptamer and electron donor. SENSORS AND ACTUATORS B-CHEMICAL, 266 (514). [PMID:] [10.1016/j.snb.2018.03.171] |
13. Yi Xiao, Linru Xu, Ping Li, Xiao-Chong Tang, Lian-Wen Qi. (2017) A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum. ANALYTICA CHIMICA ACTA, 983 (96). [PMID:28811034] [10.1016/j.aca.2017.06.014] |
14. Joel Isanga, Daniel Mukunzi, Yanni Chen, Steven Suryoprabowo, Liqiang Liu, Hua Kuang. (2017) Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs. FOOD AND AGRICULTURAL IMMUNOLOGY, 28 (4): (668-684). [PMID:] [10.1080/09540105.2017.1309361] |
15. Panpan Gai, Chengcheng Gu, Ting Hou, Feng Li. (2017) Ultrasensitive Self-Powered Aptasensor Based on Enzyme Biofuel Cell and DNA Bioconjugate: A Facile and Powerful Tool for Antibiotic Residue Detection. ANALYTICAL CHEMISTRY, 89 (3): (2163–2169). [PMID:28208296] [10.1021/acs.analchem.6b05109] |