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Lincomycin hydrochloride - 95%, high purity , CAS No.859-18-7

≥95%

CAS#: 859-18-7
Formula: C₁₈H₃₄N₂O₆S·HCl
Molecular Weight: 443
MDL number: MFCD00058237
PubChem CID: 64710

Item Number

L107359

Grouped product items
SKU	Size	Availability	Price
L107359-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$44.90
L107359-5g	5g	In stock	$158.90
L107359-25g	25g	In stock	$215.90

Antibiotic. Bacterial protein synthesis inhibitor

Basic Description

Synonyms	Lincomycin hydrochloride\|859-18-7\|LINCOMYCIN HCL\|Frademicina\|Lincomycin (hydrochloride)\|Mycivin\|Lincomycin hydrochloride anhydrous\|NSC 70731\|Lincocin\|Lincomycin HCl (Lincocin)\|GCW8Y9936L\|DTXSID7047803\|Lincomix 20\|Pura Ject 100\|NCGC00159326-02\|Lincolnensin
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Antibiotic. Bacterial protein synthesis inhibitor. Cross-links peptidyl transferase loop region of 23S rRNA. Anti-bacterial agent. Active in vivo and in vitro .
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

GALC Tbio Galactocerebrosidase 0 Activities

Discover Target: GALC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
InChi Key	POUMFISTNHIPTI-BOMBIWCESA-N
Canonical SMILES	CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
Isomeric SMILES	CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl
Alternate CAS	7179-49-9
PubChem CID	64710
Molecular Weight	443

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
C2405109	Certificate of Analysis	Mar 12, 2024	L107359
K2204779	Certificate of Analysis	Nov 12, 2022	L107359

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

References

1. S Takebe,A Numata,K Kobashi. (1984-11-01) Stone formation by Ureaplasma urealyticum in human urine and its prevention by urease inhibitors.. Journal of clinical microbiology, 20 ((5)): (869-873). [PMID:6549013]
2. J Slots,R T Evans,P M Lobbins,R J Genco. (1980-07-01) In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.. Antimicrobial agents and chemotherapy, 18 ((1)): (9-12). [PMID:6903116]
3. H Malke,W Reichardt,M Hartmann,F Walter. (1981-01-01) Genetic study of plasmid-associated zonal resistance to lincomycin in Streptococcus pyogenes.. Antimicrobial agents and chemotherapy, 19 ((1)): (91-100). [PMID:7018388]
4. Sang Hyun Cho,Saradee Warit,Baojie Wan,Chang Hwa Hwang,Guido F Pauli,Scott G Franzblau. (2007-01-11) Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.. Antimicrobial agents and chemotherapy, 51 ((4)): (1380-1385). [PMID:17210775]
5. Neelam Keswani,Sinjan Choudhary,Nand Kishore. (2010-04-02) Interaction of weakly bound antibiotics neomycin and lincomycin with bovine and human serum albumin: biophysical approach.. Journal of biochemistry, 148 ((1)): (71-84). [PMID:20356824]
6. C P Rezende,L F Souza,M P Almeida,P G Dias,M H Diniz,J C Garcia. (2012-02-11) Optimisation and validation of a quantitative and confirmatory method for residues of macrolide antibiotics and lincomycin in kidney by liquid chromatography coupled to mass spectrometry.. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29 ((4)): (587-595). [PMID:22320663]
7. Shogo Ogami,Alain Boussac,Miwa Sugiura. (2012-02-14) Deactivation processes in PsbA1-Photosystem II and PsbA3-Photosystem II under photoinhibitory conditions in the cyanobacterium Thermosynechococcus elongatus.. Biochimica et biophysica acta, 1817 ((8)): (1322-1330). [PMID:22326861]
8. Adám Tölgyesi,Jenõ Fekete,Szabolcs Fekete,Virender K Sharma,Katalin Békési,Edina Tóth. (2012-02-18) Analysis of sub μg/kg lincomycin in honey, muscle, milk, and eggs using fast liquid chromatography-tandem mass spectrometry.. Journal of chromatographic science, 50 ((3)): (190-198). [PMID:22337795]
9. Kiyun Park,Inn-Sil Kwak. (2012-05-23) Gene expression of ribosomal protein mRNA in Chironomus riparius: effects of endocrine disruptor chemicals and antibiotics.. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 156 ((2)): (113-120). [PMID:22609975]
10. Duo Wu,Han Gao,Fan Lü,Liming Shao,Simin Luo,Peiqing Xia,Pinjing He. (2012-05-31) Evaluation of inhibition relief operations for mesophilic anaerobic bio-liquefaction of lincomycin manufacturing biowaste.. Water science and technology : a journal of the International Association on Water Pollution Research, 65 ((12)): (2200-2205). [PMID:22643416]
11. Phillip A Davis,Roger P Hangarter. (2012-06-15) Chloroplast movement provides photoprotection to plants by redistributing PSII damage within leaves.. Photosynthesis research, 112 ((3)): (153-161). [PMID:22695784]
12. P Calza,C Medana,E Padovano,F Dal Bello,C Baiocchi. (2012-06-19) Identification of the unknown transformation products derived from lincomycin using LC-HRMS technique.. Journal of mass spectrometry : JMS, 47 ((6)): (751-759). [PMID:22707167]
13. Kazunori Miyata,Ko Noguchi,Ichiro Terashima. (2012-07-17) Cost and benefit of the repair of photodamaged photosystem II in spinach leaves: roles of acclimation to growth light.. Photosynthesis research, 113 ((1-3)): (165-180). [PMID:22797856]
14. Isaac M Hagenbuch,James L Pinckney. (2012-07-24) Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms.. Water research, 46 ((16)): (5028-5036). [PMID:22819871]
15. P Calza,C Medana,E Padovano,V Giancotti,C Minero. (2012-08-02) Fate of selected pharmaceuticals in river waters.. Environmental science and pollution research international, 20 ((4)): (2262-2270). [PMID:22851223]
16. Steven L Berry,Deryck H Read,Thomas R Famula,Andrea Mongini,Dörte Döpfer. (2012-08-16) Long-term observations on the dynamics of bovine digital dermatitis lesions on a California dairy after topical treatment with lincomycin HCl.. Veterinary journal (London, England : 1997), 193 ((3)): (654-658). [PMID:22892182]
17. Carmen Lozano,Carmen Aspiroz,Antonio Rezusta,Elena Gómez-Sanz,Carmen Simon,Paula Gómez,Carmelo Ortega,Maria José Revillo,Myriam Zarazaga,Carmen Torres. (2012-08-21) Identification of novel vga(A)-carrying plasmids and a Tn5406-like transposon in meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis of human and animal origin.. International journal of antimicrobial agents, 40 ((4)): (306-312). [PMID:22901706]
18. Eita Sasaki,Chia-I Lin,Ke-Yi Lin,Hung-Wen Liu. (2012-09-20) Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.. Journal of the American Chemical Society, 134 ((42)): (17432-17435). [PMID:22989310]
19. C F Williams,J E T McLain. (2012-10-27) Soil persistence and fate of carbamazepine, lincomycin, caffeine, and ibuprofen from wastewater reuse.. Journal of environmental quality, 41 ((5)): (1473-1480). [PMID:23099938]
20. Eijiro Umemura,Yoshinari Wakiyama,Ko Kumura,Kazutaka Ueda,Satomi Masaki,Takashi Watanabe,Mikio Yamamoto,Yoko Hirai,Hideki Fushimi,Takuji Yoshida,Keiichi Ajito. (2012-12-13) Synthesis of novel lincomycin derivatives and their in vitro antibacterial activities.. The Journal of antibiotics, 66 ((3)): (195-198). [PMID:23232934]
21. Dmitri N Ermolenko,Peter V Cornish,Taekjip Ha,Harry F Noller. (2012-12-20) Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.. RNA (New York, N.Y.), 19 ((2)): (158-166). [PMID:23249745]
22. Yong-Yi Chen,Ying Wang,Lung-Jiun Shin,Jing-Fen Wu,Varanavasiappan Shanmugam,Munkhtsetseg Tsednee,Jing-Chi Lo,Chyi-Chuann Chen,Shu-Hsing Wu,Kuo-Chen Yeh. (2013-01-12) Iron is involved in the maintenance of circadian period length in Arabidopsis.. Plant physiology, 161 ((3)): (1409-1420). [PMID:23307650]
23. Motohiko Ogawa,Tsuneo Uchiyama,Masaaki Satoh,Shuji Ando. (2013-02-12) Decontamination of mycoplasma-contaminated Orientia tsutsugamushi strains by repeating passages through cell cultures with antibiotics.. BMC microbiology, 13 (32-32). [PMID:23394970]
24. Ching-Chih Tseng,Chih-Jen Lee,Yi-Ting Chung,Tzu-Ying Sung,Ming-Hsiun Hsieh. (2013-05-07) Differential regulation of Arabidopsis plastid gene expression and RNA editing in non-photosynthetic tissues.. Plant molecular biology, 82 ((4-5)): (375-392). [PMID:23645360]
25. Ajay Kothadiya. (2013-06-08) A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.. Journal of the Indian Medical Association, 110 ((8)): (580-583). [PMID:23741829]
26. Reza Tabrizi,Hooman Khorshidi,Shoaleh Shahidi,Mehdi Gholami,Saman Kalbasi,Adell Khayati. (2014-02-25) Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery.. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72 ((5)): (850-857). [PMID:24560173]
27. Sonja Hillen,Hermann Willems,Werner Herbst,Judith Rohde,Gerald Reiner. (2014-06-21) Mutations in the 50S ribosomal subunit of Brachyspira hyodysenteriae associated with altered minimum inhibitory concentrations of pleuromutilins.. Veterinary microbiology, 172 ((1-2)): (223-229). [PMID:24948419]
28. Leslie C Dickson. (2014-08-16) Performance characterization of a quantitative liquid chromatography-tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967 (203-210). [PMID:25125397]
29. Qunfei Zhao,Min Wang,Dongxiao Xu,Qinglin Zhang,Wen Liu. (2015-01-22) Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.. Nature, 518 ((7537)): (115-119). [PMID:25607359]
30. Charles E Melançon. (2015-01-22) Biochemistry: Elusive source of sulfur unravelled.. Nature, 518 ((7537)): (45-46). [PMID:25607363]
31. K Stypulkowska,A Blazewicz,A Brudzikowska,M Warowna- Grzeskiewicz,K Sarna,Z Fijalek. (2015-05-06) Development of high performance liquid chromatography methods with charged aerosol detection for the determination of lincomycin, spectinomycin and its impurities in pharmaceutical products.. Journal of pharmaceutical and biomedical analysis, 112 (8-14). [PMID:25938473]
32. Shanshan Cao,Shanshan Song,Liqiang Liu,Na Kong,Hua Kuang,Chuanlai Xu. (2015-06-25) Comparison of an Enzyme-Linked Immunosorbent Assay with an Immunochromatographic Assay for Detection of Lincomycin in Milk and Honey.. Immunological investigations, 44 ((5)): (438-450). [PMID:26107744]
33. Sara Haines,Sylviane Gautheron,William Nasser,Geneviève Renauld-Mongénie. (2015-10-31) Identification of Novel Components Influencing Colonization Factor Antigen I Expression in Enterotoxigenic Escherichia coli.. PloS one, 10 ((10)): (e0141469-e0141469). [PMID:26517723]
34. Nazife Nur Yazgan Karacaglar,Ali Topcu,Fahriye Ceyda Dudak,Ismail Hakki Boyaci. (2020-01-21) Development of a green fluorescence protein (GFP)-based bioassay for detection of antibiotics and its application in milk.. Journal of food science, 85 ((2)): (500-509). [PMID:31958152]
35. J C Pechère. (1986-02-01) [Lincosamides].. Pathologie-biologie, 34 ((2)): (119-128). [PMID:3517777]
36. Michael E Ruckle,Lyle D Burgoon,Lauren A Lawrence,Christopher A Sinkler,Robert M Larkin. (2012-03-03) Plastids are major regulators of light signaling in Arabidopsis.. Plant physiology, 159 ((1)): (366-390). [PMID:22383539]
37. PanGyi Kim,Yena Park,Kyunghee Ji,Jihyun Seo,Sangwoo Lee,Kyunghee Choi,Younglim Kho,Jeongim Park,Kyungho Choi. (2012-05-09) Effect of chronic exposure to acetaminophen and lincomycin on Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa, and potential mechanisms of endocrine disruption.. Chemosphere, 89 ((1)): (10-18). [PMID:22560975]
38. Erica Belgio,Matthew P Johnson,Snježana Jurić,Alexander V Ruban. (2012-06-28) Higher plant photosystem II light-harvesting antenna, not the reaction center, determines the excited-state lifetime-both the maximum and the nonphotochemically quenched.. Biophysical journal, 102 ((12)): (2761-2771). [PMID:22735526]
39. Ulrich Schreiber,Christof Klughammer. (2013-02-15) Wavelength-dependent photodamage to Chlorella investigated with a new type of multi-color PAM chlorophyll fluorometer.. Photosynthesis research, 114 ((3)): (165-177). [PMID:23408255]
40. Milena Marsoni,Fabrizio De Mattia,Massimo Labra,Antonia Bruno,Antonella Bruno,Marcella Bracale,Candida Vannini. (2014-07-22) Uptake and effects of a mixture of widely used therapeutic drugs in Eruca sativa L. and Zea mays L. plants.. Ecotoxicology and environmental safety, 108 (52-57). [PMID:25042244]
41. Fisher, et al.. (2021) Divergence of photosynthetic strategies amongst marine diatoms.. PLoS ONE, 15 (e0244252-e0244252). [PMID:33370327]

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