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Lincomycin hydrochloride - 95%, high purity , CAS No.859-18-7

10 Citations

≥95%

CAS#: 859-18-7
Formula: C₁₈H₃₄N₂O₆S·HCl
Molecular Weight: 443
MDL number: MFCD00058237
PubChem CID: 64710

Item Number

L107359

Grouped product items
SKU	Size	Availability	Price
L107359-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$44.90
L107359-5g	5g	In stock	$158.90
L107359-25g	25g	In stock	$215.90

Antibiotic. Bacterial protein synthesis inhibitor

Basic Description

Synonyms	CCG-220302 \| Lincomycin (hydrochloride) \| Lincogap \| NCGC00159326-02 \| Lincomycin hydrochloride, >=95.0% (TLC) \| Lincomycin hydrochloride, BioReagent, suitable for cell culture \| DTXCID9027780 \| Lincomycin HCl (Lincocin) \| POUMFISTNHIPTI-BOMBIWCESA-N \| D-
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Antibiotic. Bacterial protein synthesis inhibitor. Cross-links peptidyl transferase loop region of 23S rRNA. Anti-bacterial agent. Active in vivo and in vitro .
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

GALC Tbio Galactocerebrosidase (0 Activities)

Discover Target: GALC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
InChi Key	POUMFISTNHIPTI-BOMBIWCESA-N
Canonical SMILES	CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
Isomeric SMILES	CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl
Alternate CAS	7179-49-9
PubChem CID	64710
Molecular Weight	443

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
C2405109	Certificate of Analysis	Mar 12, 2024	L107359
K2204779	Certificate of Analysis	Nov 12, 2022	L107359
F1420019	Certificate of Analysis	Apr 14, 2022	L107359
C1807105	Certificate of Analysis	Jan 19, 2022	L107359
C1807106	Certificate of Analysis	Jan 19, 2022	L107359

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Fan Yunfeng, Liu Zhimin, Wang Jie, Cui Chen, Hu Leqian. (2023) An “off–on” electrochemiluminescence aptasensor for determination of lincomycin based on CdS QDs/carboxylated g-C3N4. MICROCHIMICA ACTA, 190 (1): (1-9). [PMID:36477444] [10.1007/s00604-022-05587-w]
2. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu. (2022) Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 647 (129202). [PMID:] [10.1016/j.colsurfa.2022.129202]
3. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] [10.1016/j.colsurfa.2021.127962]
4. Gongxi Qiao, Gui Chen, Qin Wen, Wanqiang Liu, Jinwei Gao, Zhiqiang Yu, Qianming Wang. (2020) Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 580 (88). [PMID:32682119] [10.1016/j.jcis.2020.07.034]
5. Yumin Leng, Fang Hu, Chunhua Ma, Chenxi Du, Linfeng Ma, Jiao Xu, Qiyuan Lin, Zhipei Sang, Zhiwen Lu. (2019) Simple, rapid, sensitive, selective and label-free lincomycin detection by using HAuCl4 and NaOH. RSC Advances, 9 (48): (28248-28252). [PMID:35530481] [10.1039/C9RA04095A]
6. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu. (2019) A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water. ANALYST, 144 (8): (2656-2661). [PMID:30843538] [10.1039/C8AN02442A]
7. Qiong Ouyang, Fangying Kou, Nuanqin Zhang, Jintao Lian, Guoquan Tu, Zhanqiang Fang. (2019) Tea polyphenols promote Fenton-like reaction: pH self-driving chelation and reduction mechanism. CHEMICAL ENGINEERING JOURNAL, 366 (514). [PMID:] [10.1016/j.cej.2019.02.078]
8. Bo Gao, Shaonan Dong, Jiadong Liu, Lifen Liu, Qiqi Feng, Na Tan, Tingting Liu, Longli Bo, Lei Wang. (2016) Identification of intermediates and transformation pathways derived from photocatalytic degradation of five antibiotics on ZnIn2S4. CHEMICAL ENGINEERING JOURNAL, 304 (826). [PMID:] [10.1016/j.cej.2016.07.029]
9. Xiuzhong Wang, Shanshan Dong, Panpan Gai, Rui Duan, Feng Li. (2016) Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy. BIOSENSORS & BIOELECTRONICS, 82 (49). [PMID:27040941] [10.1016/j.bios.2016.03.055]
10. Hui Zhao, Zhen Wei, Shuxin Xu, Minjie Tang, Liandong Deng, Jianhua Zhang, Anjie Dong. (2015) Retracted Article: Preparation and Properties of Polymer Micelle-embedded Nanofibrous Membranes for Dual-drug Co-delivery and Multistep Release. RSC Advances, [PMID:] [10.1039/C5RA03345D]

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43. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu. (2022) Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 647 (129202). [PMID:] [10.1016/j.colsurfa.2022.129202]
44. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] [10.1016/j.colsurfa.2021.127962]
45. Gongxi Qiao, Gui Chen, Qin Wen, Wanqiang Liu, Jinwei Gao, Zhiqiang Yu, Qianming Wang. (2020) Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 580 (88). [PMID:32682119] [10.1016/j.jcis.2020.07.034]
46. Yumin Leng, Fang Hu, Chunhua Ma, Chenxi Du, Linfeng Ma, Jiao Xu, Qiyuan Lin, Zhipei Sang, Zhiwen Lu. (2019) Simple, rapid, sensitive, selective and label-free lincomycin detection by using HAuCl4 and NaOH. RSC Advances, 9 (48): (28248-28252). [PMID:35530481] [10.1039/C9RA04095A]
47. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu. (2019) A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water. ANALYST, 144 (8): (2656-2661). [PMID:30843538] [10.1039/C8AN02442A]
48. Qiong Ouyang, Fangying Kou, Nuanqin Zhang, Jintao Lian, Guoquan Tu, Zhanqiang Fang. (2019) Tea polyphenols promote Fenton-like reaction: pH self-driving chelation and reduction mechanism. CHEMICAL ENGINEERING JOURNAL, 366 (514). [PMID:] [10.1016/j.cej.2019.02.078]
49. Bo Gao, Shaonan Dong, Jiadong Liu, Lifen Liu, Qiqi Feng, Na Tan, Tingting Liu, Longli Bo, Lei Wang. (2016) Identification of intermediates and transformation pathways derived from photocatalytic degradation of five antibiotics on ZnIn2S4. CHEMICAL ENGINEERING JOURNAL, 304 (826). [PMID:] [10.1016/j.cej.2016.07.029]
50. Xiuzhong Wang, Shanshan Dong, Panpan Gai, Rui Duan, Feng Li. (2016) Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy. BIOSENSORS & BIOELECTRONICS, 82 (49). [PMID:27040941] [10.1016/j.bios.2016.03.055]
51. Hui Zhao, Zhen Wei, Shuxin Xu, Minjie Tang, Liandong Deng, Jianhua Zhang, Anjie Dong. (2015) Retracted Article: Preparation and Properties of Polymer Micelle-embedded Nanofibrous Membranes for Dual-drug Co-delivery and Multistep Release. RSC Advances, [PMID:] [10.1039/C5RA03345D]

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