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Lincomycin hydrochloride - BioReagent, suitable for cell culture, high purity , CAS No.859-18-7

8 Citations

BioReagent

for cell culture

CAS#: 859-18-7
Formula: C₁₈H₃₄N₂O₆S·HCl
Molecular Weight: 443
PubChem CID: 64710

Item Number

L434278

Grouped product items
SKU	Size	Availability	Price	Qty
L434278-1000000Units	1000000Units	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$165.90
L434278-5000000Units	5000000Units	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$574.90

Basic Description

Synonyms	CCG-220302 \| Lincomycin (hydrochloride) \| Lincogap \| NCGC00159326-02 \| Lincomycin hydrochloride, >=95.0% (TLC) \| Lincomycin hydrochloride, BioReagent, suitable for cell culture \| DTXCID9027780 \| Lincomycin HCl (Lincocin) \| POUMFISTNHIPTI-BOMBIWCESA-N \| D-
Specifications & Purity	BioReagent, for cell culture
Biochemical and Physiological Mechanisms	Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.† Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	BioReagent, for cell culture
Product Description	General Description Chemical structure: macrolide Application Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

Associated Targets(Human)

GALC Tbio Galactocerebrosidase (0 Activities)

Discover Target: GALC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1
InChi Key	POUMFISTNHIPTI-BOMBIWCESA-N
Canonical SMILES	CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
Isomeric SMILES	CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl
Alternate CAS	7179-49-9
PubChem CID	64710
Molecular Weight	443

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	H2O: 4mL, clear, colorless to faintly yellow (200 mg + 4 mL H2O)

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

FAQs and Articles

FAQ

Antibiotics block bacterial protein synthesis

Categories: Technical articles

Tags:

Antibiotics Tetra Aminoglycosides Macrolides Peptidyl transferase inhibitors Antibiotics for cell culture

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] [10.1016/j.colsurfa.2021.127962]
2. Gongxi Qiao, Gui Chen, Qin Wen, Wanqiang Liu, Jinwei Gao, Zhiqiang Yu, Qianming Wang. (2020) Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 580 (88). [PMID:32682119] [10.1016/j.jcis.2020.07.034]
3. Yumin Leng, Fang Hu, Chunhua Ma, Chenxi Du, Linfeng Ma, Jiao Xu, Qiyuan Lin, Zhipei Sang, Zhiwen Lu. (2019) Simple, rapid, sensitive, selective and label-free lincomycin detection by using HAuCl4 and NaOH. RSC Advances, 9 (48): (28248-28252). [PMID:35530481] [10.1039/C9RA04095A]
4. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu. (2019) A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water. ANALYST, 144 (8): (2656-2661). [PMID:30843538] [10.1039/C8AN02442A]
5. Qiong Ouyang, Fangying Kou, Nuanqin Zhang, Jintao Lian, Guoquan Tu, Zhanqiang Fang. (2019) Tea polyphenols promote Fenton-like reaction: pH self-driving chelation and reduction mechanism. CHEMICAL ENGINEERING JOURNAL, 366 (514). [PMID:] [10.1016/j.cej.2019.02.078]
6. Bo Gao, Shaonan Dong, Jiadong Liu, Lifen Liu, Qiqi Feng, Na Tan, Tingting Liu, Longli Bo, Lei Wang. (2016) Identification of intermediates and transformation pathways derived from photocatalytic degradation of five antibiotics on ZnIn2S4. CHEMICAL ENGINEERING JOURNAL, 304 (826). [PMID:] [10.1016/j.cej.2016.07.029]
7. Xiuzhong Wang, Shanshan Dong, Panpan Gai, Rui Duan, Feng Li. (2016) Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy. BIOSENSORS & BIOELECTRONICS, 82 (49). [PMID:27040941] [10.1016/j.bios.2016.03.055]
8. Hui Zhao, Zhen Wei, Shuxin Xu, Minjie Tang, Liandong Deng, Jianhua Zhang, Anjie Dong. (2015) Retracted Article: Preparation and Properties of Polymer Micelle-embedded Nanofibrous Membranes for Dual-drug Co-delivery and Multistep Release. RSC Advances, [PMID:] [10.1039/C5RA03345D]

References

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3. Adám Tölgyesi,Jenõ Fekete,Szabolcs Fekete,Virender K Sharma,Katalin Békési,Edina Tóth. (2012-02-18) Analysis of sub μg/kg lincomycin in honey, muscle, milk, and eggs using fast liquid chromatography-tandem mass spectrometry.. Journal of chromatographic science, 50 ((3)): (190-198). [PMID:22337795]
4. Kiyun Park,Inn-Sil Kwak. (2012-05-23) Gene expression of ribosomal protein mRNA in Chironomus riparius: effects of endocrine disruptor chemicals and antibiotics.. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 156 ((2)): (113-120). [PMID:22609975]
5. Duo Wu,Han Gao,Fan Lü,Liming Shao,Simin Luo,Peiqing Xia,Pinjing He. (2012-05-31) Evaluation of inhibition relief operations for mesophilic anaerobic bio-liquefaction of lincomycin manufacturing biowaste.. Water science and technology : a journal of the International Association on Water Pollution Research, 65 ((12)): (2200-2205). [PMID:22643416]
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9. Isaac M Hagenbuch,James L Pinckney. (2012-07-24) Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms.. Water research, 46 ((16)): (5028-5036). [PMID:22819871]
10. P Calza,C Medana,E Padovano,V Giancotti,C Minero. (2012-08-02) Fate of selected pharmaceuticals in river waters.. Environmental science and pollution research international, 20 ((4)): (2262-2270). [PMID:22851223]
11. Steven L Berry,Deryck H Read,Thomas R Famula,Andrea Mongini,Dörte Döpfer. (2012-08-16) Long-term observations on the dynamics of bovine digital dermatitis lesions on a California dairy after topical treatment with lincomycin HCl.. Veterinary journal (London, England : 1997), 193 ((3)): (654-658). [PMID:22892182]
12. Carmen Lozano,Carmen Aspiroz,Antonio Rezusta,Elena Gómez-Sanz,Carmen Simon,Paula Gómez,Carmelo Ortega,Maria José Revillo,Myriam Zarazaga,Carmen Torres. (2012-08-21) Identification of novel vga(A)-carrying plasmids and a Tn5406-like transposon in meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis of human and animal origin.. International journal of antimicrobial agents, 40 ((4)): (306-312). [PMID:22901706]
13. Eita Sasaki,Chia-I Lin,Ke-Yi Lin,Hung-Wen Liu. (2012-09-20) Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN.. Journal of the American Chemical Society, 134 ((42)): (17432-17435). [PMID:22989310]
14. C F Williams,J E T McLain. (2012-10-27) Soil persistence and fate of carbamazepine, lincomycin, caffeine, and ibuprofen from wastewater reuse.. Journal of environmental quality, 41 ((5)): (1473-1480). [PMID:23099938]
15. Eijiro Umemura,Yoshinari Wakiyama,Ko Kumura,Kazutaka Ueda,Satomi Masaki,Takashi Watanabe,Mikio Yamamoto,Yoko Hirai,Hideki Fushimi,Takuji Yoshida,Keiichi Ajito. (2012-12-13) Synthesis of novel lincomycin derivatives and their in vitro antibacterial activities.. The Journal of antibiotics, 66 ((3)): (195-198). [PMID:23232934]
16. Dmitri N Ermolenko,Peter V Cornish,Taekjip Ha,Harry F Noller. (2012-12-20) Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.. RNA (New York, N.Y.), 19 ((2)): (158-166). [PMID:23249745]
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18. Ching-Chih Tseng,Chih-Jen Lee,Yi-Ting Chung,Tzu-Ying Sung,Ming-Hsiun Hsieh. (2013-05-07) Differential regulation of Arabidopsis plastid gene expression and RNA editing in non-photosynthetic tissues.. Plant molecular biology, 82 ((4-5)): (375-392). [PMID:23645360]
19. Ajay Kothadiya. (2013-06-08) A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.. Journal of the Indian Medical Association, 110 ((8)): (580-583). [PMID:23741829]
20. Reza Tabrizi,Hooman Khorshidi,Shoaleh Shahidi,Mehdi Gholami,Saman Kalbasi,Adell Khayati. (2014-02-25) Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery.. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72 ((5)): (850-857). [PMID:24560173]
21. Sonja Hillen,Hermann Willems,Werner Herbst,Judith Rohde,Gerald Reiner. (2014-06-21) Mutations in the 50S ribosomal subunit of Brachyspira hyodysenteriae associated with altered minimum inhibitory concentrations of pleuromutilins.. Veterinary microbiology, 172 ((1-2)): (223-229). [PMID:24948419]
22. Leslie C Dickson. (2014-08-16) Performance characterization of a quantitative liquid chromatography-tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967 (203-210). [PMID:25125397]
23. K Stypulkowska,A Blazewicz,A Brudzikowska,M Warowna- Grzeskiewicz,K Sarna,Z Fijalek. (2015-05-06) Development of high performance liquid chromatography methods with charged aerosol detection for the determination of lincomycin, spectinomycin and its impurities in pharmaceutical products.. Journal of pharmaceutical and biomedical analysis, 112 (8-14). [PMID:25938473]
24. Shanshan Cao,Shanshan Song,Liqiang Liu,Na Kong,Hua Kuang,Chuanlai Xu. (2015-06-25) Comparison of an Enzyme-Linked Immunosorbent Assay with an Immunochromatographic Assay for Detection of Lincomycin in Milk and Honey.. Immunological investigations, 44 ((5)): (438-450). [PMID:26107744]
25. Sara Haines,Sylviane Gautheron,William Nasser,Geneviève Renauld-Mongénie. (2015-10-31) Identification of Novel Components Influencing Colonization Factor Antigen I Expression in Enterotoxigenic Escherichia coli.. PloS one, 10 ((10)): (e0141469-e0141469). [PMID:26517723]
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31. Liu Duan,M Águila Ruiz-Sola,Ana Couso,Nil Veciana,Elena Monte. (2020-05-05) Red and blue light differentially impact retrograde signalling and photoprotection in rice.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 375 ((1801)): (20190402-20190402). [PMID:32362254]
32. Yu-yu Guo, Yu-rui Hu, Shao-ke Chen, Ming-zhu Guo, Yi-ting Zhang, Xin-rui Han, Shen Zhang. (2022) Facile one-pot synthesis of tannic acid-stabilized fluorescent copper nanoclusters and its application as sensing probes for chlortetracycline based on inner filter effect. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 634 (127962). [PMID:] [10.1016/j.colsurfa.2021.127962]
33. Gongxi Qiao, Gui Chen, Qin Wen, Wanqiang Liu, Jinwei Gao, Zhiqiang Yu, Qianming Wang. (2020) Rapid conversion from common precursors to carbon dots in large scale: Spectral controls, optical sensing, cellular imaging and LEDs application. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 580 (88). [PMID:32682119] [10.1016/j.jcis.2020.07.034]
34. Yumin Leng, Fang Hu, Chunhua Ma, Chenxi Du, Linfeng Ma, Jiao Xu, Qiyuan Lin, Zhipei Sang, Zhiwen Lu. (2019) Simple, rapid, sensitive, selective and label-free lincomycin detection by using HAuCl4 and NaOH. RSC Advances, 9 (48): (28248-28252). [PMID:35530481] [10.1039/C9RA04095A]
35. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu. (2019) A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water. ANALYST, 144 (8): (2656-2661). [PMID:30843538] [10.1039/C8AN02442A]
36. Qiong Ouyang, Fangying Kou, Nuanqin Zhang, Jintao Lian, Guoquan Tu, Zhanqiang Fang. (2019) Tea polyphenols promote Fenton-like reaction: pH self-driving chelation and reduction mechanism. CHEMICAL ENGINEERING JOURNAL, 366 (514). [PMID:] [10.1016/j.cej.2019.02.078]
37. Bo Gao, Shaonan Dong, Jiadong Liu, Lifen Liu, Qiqi Feng, Na Tan, Tingting Liu, Longli Bo, Lei Wang. (2016) Identification of intermediates and transformation pathways derived from photocatalytic degradation of five antibiotics on ZnIn2S4. CHEMICAL ENGINEERING JOURNAL, 304 (826). [PMID:] [10.1016/j.cej.2016.07.029]
38. Xiuzhong Wang, Shanshan Dong, Panpan Gai, Rui Duan, Feng Li. (2016) Highly sensitive homogeneous electrochemical aptasensor for antibiotic residues detection based on dual recycling amplification strategy. BIOSENSORS & BIOELECTRONICS, 82 (49). [PMID:27040941] [10.1016/j.bios.2016.03.055]
39. Hui Zhao, Zhen Wei, Shuxin Xu, Minjie Tang, Liandong Deng, Jianhua Zhang, Anjie Dong. (2015) Retracted Article: Preparation and Properties of Polymer Micelle-embedded Nanofibrous Membranes for Dual-drug Co-delivery and Multistep Release. RSC Advances, [PMID:] [10.1039/C5RA03345D]

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