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Linifanib (ABT-869) - ≥99%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.796967-16-3, Vascular endothelial growth factor receptor inhibitor
Basic Description Synonyms Linifanib|796967-16-3|ABT-869|Linifanib (ABT-869)|1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea|AL-39324|ABT 869|1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea|Linifanib (GMP)|N-[4-(3-amino-1H-indazol-4-yl)ph Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (Flt/Flk) and PDGFR families (e.g., KDR, Flt1, Flt3, Flt4, CSF-1R, and KIT) demonstrating IC50 values ra Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Vascular endothelial growth factor receptor inhibitor Note 5mg、50mg卖完停产，不再备货 Product Description Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3). Phase 3.
Names and Identifiers IUPAC Name 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea INCHI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) InChi Key MPVGZUGXCQEXTM-UHFFFAOYSA-N Canonical SMILES CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N Isomeric SMILES CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N PubChem CID 11485656 Molecular Weight 375.41
Chemical and Physical Properties Solubility Soluble in water (<1 mg/ml) at 25 °C, DMSO (~20 mg/ml), DMF (~20 mg/ml), 1:5 DMSO:PBS (pH 7.2) (~0.2 mg/ml), ethanol (5 mg/ml) at 25 °C, and methanol.
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS09 Signal Danger Hazard Statements H400: Very toxic to aquatic life
H410: Very toxic to aquatic life with long lasting effects
H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
References 1. Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, Li J, Guo J, Bousquet PF, Ghoreishi-Haack NS et al. . (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.. Mol Cancer Ther, 5 (4): (995-1006). [PMID:16648571 ]
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