Linrodostat (BMS-986205) - 98%, high purity , CAS No.1923833-60-6, Inhibitor of indoleamine 2;3-dioxygenase 1

Item Number

L414088

Grouped product items
SKU	Size	Availability	Price
L414088-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$64.90
L414088-10mg	10mg	In stock	$97.90
L414088-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$195.90
L414088-50mg	50mg	In stock	$325.90
L414088-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$521.90

IDO/TDO Inhibitors

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Basic Description

Synonyms	ONO7701 \| ONO-7701 \| ONO 7701 \| s8629 \| 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-?-D-ribofuranuronamide \| Linrodostat \| SCHEMBL21374258 \| (R)-N-(4-chlorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide;(R)-N-(4-chlorophenyl)-2-((1s,4S)-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of indoleamine 2;3-dioxygenase 1
Product Description	Information Linrodostat (BMS-986205) Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays. Targets IDO1 (Cell-free assay) 1.7 nM In vitro BMS-986205 exhibits potent inhibition of kynurenine (kyn) production in IDO1-HEK293 cells (IC50 = 1.1 nM) but not in TDO-HEK293 cells. It is an irreversible suicide inhibitor. Product description： BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Names and Identifiers

IUPAC Name	(2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide
INCHI	InChI=1S/C24H24ClFN2O/c1-15(24(29)28-20-9-6-18(25)7-10-20)16-2-4-17(5-3-16)21-12-13-27-23-11-8-19(26)14-22(21)23/h6-17H,2-5H2,1H3,(H,28,29)/t15-,16?,17?/m1/s1
InChi Key	KRTIYQIPSAGSBP-KLAILNCOSA-N
Canonical SMILES	CC(C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl
Isomeric SMILES	C[C@H](C1CCC(CC1)C2=C3C=C(C=CC3=NC=C2)F)C(=O)NC4=CC=C(C=C4)Cl
Alternate CAS	1923833-60-6
PubChem CID	121328278
MeSH Entry Terms	(2R)-N-(4-Chlorophenyl)-2-(cis-4-(6-fluoro-4-quinolinyl)cyclohexyl)propanamide;BMS-986205;Cyclohexaneacetamide, N-(4-chlorophenyl)-4-(6-fluoro-4-quinolinyl)-\u03b1-methyl-, cis-;linrodostat
Molecular Weight	410.91

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
G2216554	Certificate of Analysis	Jun 07, 2022	L414088
G2216555	Certificate of Analysis	Jun 07, 2022	L414088
G2216556	Certificate of Analysis	Jun 07, 2022	L414088

References

1. Li F, Zhang R, Li S, Liu J. (2017) IDO1: An important immunotherapy target in cancer treatment.. Int Immunopharmacol, 47 (13): (70-77). [PMID:28365507] [10.1021/op500134e]
2. Nelp MT, Kates PA, Hunt JT, Newitt JA, Balog A, Maley D, Zhu X, Abell L, Allentoff A, Borzilleri R et al.. (2018) Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.. Proc Natl Acad Sci USA, 115 (13): (3249-3254). [PMID:29531094] [10.1021/op500134e]

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Basic Description