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Lipoxin A4 - ≥95%，100µg/ml in ethanol, high purity , CAS No.89663-86-5, Agonist of FPR2/ALX;Agonist of FPR3;Agonist of GPR32

Moligand™

≥95%
100µg/ml in ethanol

CAS#: 89663-86-5
Formula: C₂₀H₃₂O₅
Molecular Weight: 352.47
EC Number: 200-578-6
PubChem CID: 5280914

Item Number

L345922

Grouped product items
SKU	Size	Availability	Price	Qty
L345922-25μg	25μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$819.90
L345922-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,319.90

a trihydroxy fatty acid produced through 15-HETE metabolism

View related series

Endogenous Metabolite FPR2/ALX Agonist FPR3 Agonist GPR32 Agonist Immunology/Inflammation Interleukin Related Metabolic Enzyme/Protease

Basic Description

Synonyms	(7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoate \| GTPL1034 \| 7,9,11,13-Eicosatetraenoic acid, 5,6,15-trihydroxy-, (5S,6R,7E,9E,11Z,13E,15S)- \| F7C6J3D79J \| NCGC00161280-03 \| (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11
Specifications & Purity	Moligand™, ≥95%, 100µg/ml in ethanol
Biochemical and Physiological Mechanisms	Lipoprotein A4 (LXA4) is synthesized from arachidonic acid and is an endogenous lipoxygenase derived arachidonic acid mediator. It is an effective activator of human protein kinase C. It inhibits the cytotoxicity of natural killer cells. LXA4 regulates th
Storage Temp	Argon charged,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of FPR2/ALX;Agonist of FPR3;Agonist of GPR32
Note	Store as supplied at -80° C for up to 1 year.
Product Description	Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM.

Associated Targets(Human)

GPR32 Tchem Probable G-protein coupled receptor 32 (1 Activities)

Discover Target: GPR32

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 (7 Activities)

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR3 Tchem N-formyl peptide receptor 3 (1 Activities)

Discover Target: FPR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FPR2 Tchem Lipoxin A4 receptor (3472 Activities)

Discover Target: FPR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NFKB2 Tchem Nuclear factor NF-kappa-B complex (2307 Activities)

Discover Target: NFKB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
INCHI	InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
InChi Key	IXAQOQZEOGMIQS-SSQFXEBMSA-N
Canonical SMILES	CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O
Isomeric SMILES	CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O
WGK Germany	2
PubChem CID	5280914
Molecular Weight	352.47

PubChem CID

ChEMBL Ligand

CAS Registry No.

ChEBI

GPCRdb Ligand

LXA₄

Solubility

Soluble in ethanol, DMSO (≥50 mg/ml), DMF (≥50 mg/ml), and PBS (pH 7.2) (≥1 mg/ml).

Refractive Index

n20D1.54

Boil Point(°C)

78° C

Safety and Hazards(GHS)

Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H225:Highly Flammable liquid and vapor
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P403+P235:Store in a well-ventilated place. Keep cool. P337+P313:IF eye irritation persists: Get medical advice/attention.
WGK Germany	2
RIDADR	UN1170-class3-PG2-Ethanol，solution

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Lipoxin A4 - ≥95%，100µg/ml in ethanol, high purity , CAS No.89663-86-5, Agonist of FPR2/ALX;Agonist of FPR3;Agonist of GPR32

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

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