Liproxstatin-1 - 97%, high purity , CAS No.950455-15-9

Item Number

L413818

• Synonyms: N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine；N-[(3-chlorophenyl)methyl]spiro[4H-quinoxaline-3,4'-piperidine]-2-amine
• Specifications & Purity: ≥97%
• Biochemical and Physiological Mechanisms: Liproxstatin-1 is a potent inhibitor of iron death, a non apoptotic form of cell death characterized by iron dependent lethal accumulation of lipid reactive oxygen species (ROS). Liproxstatin-1 inhibited iron death in human cells and ischemia / reperfusio
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

Liproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

Targets

ferroptosis (Cell-free assay) 22 nM

In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4^−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4^−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H₂O₂ (200 µM).

In vivo

Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.

Cell Research(from reference)

Cell lines：Gpx4^−/−cells 

Concentrations：~200 nM 

Incubation Time：~72 h