Grouped product items

SKU

Size

Availability

Price

Qty

L752230-100mg

100mg

Available within 8-12 weeks(?)

$54.90

L752230-250mg

250mg

Available within 8-12 weeks(?)

$94.90

L752230-1g

Available within 8-12 weeks(?)

$265.90

Basic Description

Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liq
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Product Description	Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants. Application： Liquiritigenin has been used:to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer；as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract；as a potential antiviral drug against hepatitis C virus (HCV) infection.

Associated Targets(Human)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)

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TYR Tclin Tyrosinase (717 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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XDH Tclin Xanthine dehydrogenase (1038 Activities)

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ESR2 Tclin Estrogen receptor beta (9272 Activities)

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JUN Tchem Proto-oncogene c-JUN (434 Activities)

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CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)

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MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

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CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)

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MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)

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MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

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YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)

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CCRF-CEM (65223 Activities)

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DU-145 (51482 Activities)

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HCT-8 (3484 Activities)

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HL-60 (67320 Activities)

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HT-1080 (3966 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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PANC-1 (6144 Activities)

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SGC-7901 (2773 Activities)

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SW480 (6023 Activities)

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U-937 (7138 Activities)

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A549 (127892 Activities)

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T47D (39041 Activities)

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HCT-116 (91556 Activities)

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HepG2 (196354 Activities)

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Ishikawa (877 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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RELA Tchem Nuclear factor NF-kappa-B p65 subunit (627 Activities)

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PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)

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Associated Targets(non-human)

NA Neuraminidase (1107 Activities)

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Mmp13 Matrix metalloproteinase 13 (19 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Influenza A virus (11224 Activities)

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B16 (5829 Activities)

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MDCK (10148 Activities)

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RAW264.7 (28094 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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Prevotella intermedia (369 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

prtC Collagenase (8 Activities)

Discover Target: prtC

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
INCHI	InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChi Key	FURUXTVZLHCCNA-AWEZNQCLSA-N
Canonical SMILES	Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2
Isomeric SMILES	C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
WGK Germany	3
RTECS	DJ2981789
PubChem CID	114829
Molecular Weight	256.25
Beilstein	359378

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO: 100 mg/mL (390.24 mM), Sonication is recommended.

Safety and Hazards(GHS)

WGK Germany	3
RTECS	DJ2981789

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xiaoran Ning, Yanhui Ni, Jingjing Cao, Huaxing Zhang. (2023) Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice. CHEMICAL & PHARMACEUTICAL BULLETIN, 71 (4): (269-276). [PMID:37005251] [10.1248/cpb.c22-00684]
2. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855]
3. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044]

References

1. Xiaoran Ning, Yanhui Ni, Jingjing Cao, Huaxing Zhang. (2023) Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice. CHEMICAL & PHARMACEUTICAL BULLETIN, 71 (4): (269-276). [PMID:37005251] [10.1248/cpb.c22-00684]
2. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855]
3. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044]

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Liquiritigenin

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
L752230-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$54.90
L752230-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$94.90
L752230-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$265.90