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Liquiritin - ≥98% (HPLC) ,from Glycyrrhizae root (licorice root), high purity , CAS No.551-15-5

5 Citations
  • ≥98%(HPLC)
Item Number
L101535
Grouped product items
SKUSizeAvailabilityPrice Qty
L101535-10mg
10mg
In stock
$78.90
L101535-50mg
50mg
In stock
$246.90
L101535-250mg
250mg
In stock
$1,111.90
L101535-1g
1g
In stock
$4,001.90
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Basic Description

SynonymsLIQUIRITIGENIN 4'-beta-D-GLUCOPYRANOSIDE | (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)phenyl]chroman-4-one | CHEBI:80845 | CCG-268869 | (2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymet
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsLiquiritin has been attributed to show antidepressant-like and antioxidant activity. It causes apoptosis in cell lines having gastric cancer and promyelocytic leukemia. Liquiritin also demonstrates neurotrophic effects and hence has been considered as a p
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
Product Description

Product Describtion:

Liquiritin is a type of flavone, present as an active ingredient in Glycyrrhiza uralensis and Glycyrrhiza glabra extract. It is a constituent of many traditional Chinese medicine formulas popularly used as a cure for asthma, peptic ulcers, and cough.

Product Application:

Liquiritin has been used to analyze the extract of Glycyrrhiza uralensis and examine its components for anti-Hepatitis C virus activity.  

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P4HB Tchem Protein disulfide-isomerase (716 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
microRNA 21 (64692 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza A virus (11224 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Giardia (1682 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one
INCHI InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
InChi Key DEMKZLAVQYISIA-ZRWXNEIDSA-N
Canonical SMILES C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
Isomeric SMILES C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
PubChem CID 503737
Molecular Weight 418.39

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
K2228228Certificate of AnalysisSep 13, 2024 L101535
K2228230Certificate of AnalysisSep 13, 2024 L101535
D2425045Certificate of AnalysisJul 08, 2023 L101535
H2304386Certificate of AnalysisJul 08, 2023 L101535
H2304390Certificate of AnalysisJul 08, 2023 L101535
H2304391Certificate of AnalysisJul 08, 2023 L101535
H2304392Certificate of AnalysisJul 08, 2023 L101535
H2304393Certificate of AnalysisJul 08, 2023 L101535
H2304394Certificate of AnalysisJul 08, 2023 L101535
G2306146Certificate of AnalysisAug 23, 2022 L101535
K2228229Certificate of AnalysisAug 23, 2022 L101535
K2004095Certificate of AnalysisAug 12, 2022 L101535
A2208083Certificate of AnalysisDec 17, 2021 L101535
A2208111Certificate of AnalysisDec 17, 2021 L101535
A2208112Certificate of AnalysisDec 17, 2021 L101535
A2208114Certificate of AnalysisDec 17, 2021 L101535

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Chemical and Physical Properties

SensitivityHeat Sensitive
Melt Point(°C)207°C

Related Documents

 SDS

 Specification Sheet

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Citations of This Product

1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu.  (2023)  Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.  JOURNAL OF ETHNOPHARMACOLOGY,    (117136).  [PMID:37704122]
2. Yinhuang Gao, Ke Ma, Zhibo Zhu, Yan Zhang, Qiong Zhou, Jing Wang, Xiaowen Guo, Liuting Luo, Haitao Wang, Kang Peng, Menghua Liu.  (2023)  Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways.  PHYTOMEDICINE,  114  (154797).  [PMID:37037084]
3. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen.  (2022)  Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.  BIOMEDICINE & PHARMACOTHERAPY,  154  (113571).  [PMID:36007273]
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372]
5. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]

References

1. Zhiyu Zhao,Weixing Wang,Hongzhu Guo,Dongfeng Zhou.  (2008-07-29)  Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats..  Behavioural brain research,  194  ((1)): (108-113).  [PMID:18655806]
2. Myrna Adianti,Chie Aoki,Mari Komoto,Lin Deng,Ikuo Shoji,Tutik Sri Wahyuni,Maria Inge Lusida,Soetjipto,Hiroyuki Fuchino,Nobuo Kawahara,Hak Hotta.  (2014-01-09)  Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species..  Microbiology and immunology,  58  ((3)): (180-187).  [PMID:24397541]
3. Qiuyan Guo,Koji Mizuno,Katsuki Okuyama,Na Lin,Yanqiong Zhang,Hideki Hayashi,Norio Takagi,Takashi Sato.  (2020-01-17)  Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells..  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,  123  (109812-109812).  [PMID:31945696]
4. M Amer,M Metwalli.  (2000-05-16)  Topical liquiritin improves melasma..  International journal of dermatology,  39  ((4)): (299-301).  [PMID:10809983]
5. Zheng-Ai Chen,Jun-Long Wang,Rui-Ting Liu,Jian-Ping Ren,Li-Qing Wen,Xiao-Juan Chen,Guang-Xing Bian.  (2009-10-01)  Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells..  Cytotechnology,  60  ((1-3)): (125-132).  [PMID:19789989]
6. Ji-Yeon Yu,Jae Yeo Ha,Kyung-Mi Kim,Young-Suk Jung,Jae-Chul Jung,Seikwan Oh.  (2015-07-25)  Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver..  Molecules (Basel, Switzerland),  20  ((7)): (13041-13054).  [PMID:26205049]
7. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu.  (2023)  Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation.  JOURNAL OF ETHNOPHARMACOLOGY,    (117136).  [PMID:37704122]
8. Yinhuang Gao, Ke Ma, Zhibo Zhu, Yan Zhang, Qiong Zhou, Jing Wang, Xiaowen Guo, Liuting Luo, Haitao Wang, Kang Peng, Menghua Liu.  (2023)  Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways.  PHYTOMEDICINE,  114  (154797).  [PMID:37037084]
9. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen.  (2022)  Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling.  BIOMEDICINE & PHARMACOTHERAPY,  154  (113571).  [PMID:36007273]
10. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang.  (2022)  Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin.  Food & Function,  13  (9): (5061-5074).  [PMID:35404372]
11. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao.  (2018-09-04)  Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach..  Food chemistry,  270  (257-263).  [PMID:30174044]

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