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L101535-10mg

10mg

In stock

$78.90

L101535-50mg

50mg

In stock

$246.90

L101535-250mg

250mg

In stock

$1,111.90

L101535-1g

In stock

$4,001.90

Basic Description

Synonyms	LIQUIRITIGENIN 4'-beta-D-GLUCOPYRANOSIDE \| (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)phenyl]chroman-4-one \| CHEBI:80845 \| CCG-268869 \| (2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymet
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Liquiritin has been attributed to show antidepressant-like and antioxidant activity. It causes apoptosis in cell lines having gastric cancer and promyelocytic leukemia. Liquiritin also demonstrates neurotrophic effects and hence has been considered as a p
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Product Description	Product Describtion: Liquiritin is a type of flavone, present as an active ingredient in Glycyrrhiza uralensis and Glycyrrhiza glabra extract. It is a constituent of many traditional Chinese medicine formulas popularly used as a cure for asthma, peptic ulcers, and cough. Product Application: Liquiritin has been used to analyze the extract of Glycyrrhiza uralensis and examine its components for anti-Hepatitis C virus activity.

Associated Targets(Human)

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

XDH Tclin Xanthine dehydrogenase (1038 Activities)

Discover Target: XDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P4HB Tchem Protein disulfide-isomerase (716 Activities)

Discover Target: P4HB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

Discover Target: MBNL1

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microRNA 21 (64692 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

NA Neuraminidase (1107 Activities)

Discover Target: NA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

Discover Target: Ptpn1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Influenza A virus (11224 Activities)

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MDCK (10148 Activities)

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Giardia (1682 Activities)

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2,3-dihydrochromen-4-one
INCHI	InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1
InChi Key	DEMKZLAVQYISIA-ZRWXNEIDSA-N
Canonical SMILES	C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
Isomeric SMILES	C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
PubChem CID	503737
Molecular Weight	418.39

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot Number	Certificate Type	Date	Item
K2228230	Certificate of Analysis	Sep 13, 2024	L101535
K2228228	Certificate of Analysis	Sep 13, 2024	L101535
H2304390	Certificate of Analysis	Jul 08, 2023	L101535
H2304394	Certificate of Analysis	Jul 08, 2023	L101535
H2304393	Certificate of Analysis	Jul 08, 2023	L101535
H2304392	Certificate of Analysis	Jul 08, 2023	L101535
H2304391	Certificate of Analysis	Jul 08, 2023	L101535
H2304386	Certificate of Analysis	Jul 08, 2023	L101535
D2425045	Certificate of Analysis	Jul 08, 2023	L101535
G2306146	Certificate of Analysis	Aug 23, 2022	L101535
K2228229	Certificate of Analysis	Aug 23, 2022	L101535
K2004095	Certificate of Analysis	Aug 12, 2022	L101535
G1809149	Certificate of Analysis	Feb 23, 2022	L101535
A2208083	Certificate of Analysis	Dec 17, 2021	L101535
A2208114	Certificate of Analysis	Dec 17, 2021	L101535
A2208112	Certificate of Analysis	Dec 17, 2021	L101535
A2208111	Certificate of Analysis	Dec 17, 2021	L101535

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Chemical and Physical Properties

Sensitivity	Heat Sensitive
Melt Point(°C)	207°C

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, (117136). [PMID:37704122] [10.1016/j.jep.2023.117136]
2. Yinhuang Gao, Ke Ma, Zhibo Zhu, Yan Zhang, Qiong Zhou, Jing Wang, Xiaowen Guo, Liuting Luo, Haitao Wang, Kang Peng, Menghua Liu. (2023) Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways. PHYTOMEDICINE, 114 (154797). [PMID:37037084] [10.1016/j.phymed.2023.154797]
3. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen. (2022) Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling. BIOMEDICINE & PHARMACOTHERAPY, 154 (113571). [PMID:36007273] [10.1016/j.biopha.2022.113571]
4. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H]
5. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, 1241 (130686). [PMID:] [10.1016/j.molstruc.2021.130686]
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519]
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807]
8. Li Peng, Manman Zhu, Lingyi Zhang, Haiyan Liu, Weibing Zhang. (2016) Preparation and evaluation of 3 m open tubular capillary columns with a zwitterionic polymeric porous layer for liquid chromatography. JOURNAL OF SEPARATION SCIENCE, 39 (19): (3736-3744). [PMID:27511867] [10.1002/jssc.201600535]
9. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855]
10. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044]

References

1. Zhiyu Zhao,Weixing Wang,Hongzhu Guo,Dongfeng Zhou. (2008-07-29) Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats.. Behavioural brain research, 194 ((1)): (108-113). [PMID:18655806]
2. Myrna Adianti,Chie Aoki,Mari Komoto,Lin Deng,Ikuo Shoji,Tutik Sri Wahyuni,Maria Inge Lusida,Soetjipto,Hiroyuki Fuchino,Nobuo Kawahara,Hak Hotta. (2014-01-09) Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.. Microbiology and immunology, 58 ((3)): (180-187). [PMID:24397541]
3. Qiuyan Guo,Koji Mizuno,Katsuki Okuyama,Na Lin,Yanqiong Zhang,Hideki Hayashi,Norio Takagi,Takashi Sato. (2020-01-17) Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 123 (109812-109812). [PMID:31945696]
4. M Amer,M Metwalli. (2000-05-16) Topical liquiritin improves melasma.. International journal of dermatology, 39 ((4)): (299-301). [PMID:10809983]
5. Zheng-Ai Chen,Jun-Long Wang,Rui-Ting Liu,Jian-Ping Ren,Li-Qing Wen,Xiao-Juan Chen,Guang-Xing Bian. (2009-10-01) Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.. Cytotechnology, 60 ((1-3)): (125-132). [PMID:19789989]
6. Ji-Yeon Yu,Jae Yeo Ha,Kyung-Mi Kim,Young-Suk Jung,Jae-Chul Jung,Seikwan Oh. (2015-07-25) Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver.. Molecules (Basel, Switzerland), 20 ((7)): (13041-13054). [PMID:26205049]
7. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, (117136). [PMID:37704122] [10.1016/j.jep.2023.117136]
8. Yinhuang Gao, Ke Ma, Zhibo Zhu, Yan Zhang, Qiong Zhou, Jing Wang, Xiaowen Guo, Liuting Luo, Haitao Wang, Kang Peng, Menghua Liu. (2023) Modified Erchen decoction ameliorates cognitive dysfunction in vascular dementia rats via inhibiting JAK2/STAT3 and JNK/BAX signaling pathways. PHYTOMEDICINE, 114 (154797). [PMID:37037084] [10.1016/j.phymed.2023.154797]
9. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen. (2022) Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling. BIOMEDICINE & PHARMACOTHERAPY, 154 (113571). [PMID:36007273] [10.1016/j.biopha.2022.113571]
10. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H]
11. Xiangrong Li, Hongyi Liu, Zhenhua Yang, Hanxiao Duan, Ziyang Wang, Zeqing Cheng, Zhizhi Song, Xinzhe Wu. (2021) Study on the interaction of hyaluronidase with certain flavonoids. JOURNAL OF MOLECULAR STRUCTURE, 1241 (130686). [PMID:] [10.1016/j.molstruc.2021.130686]
12. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519]
13. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807]
14. Li Peng, Manman Zhu, Lingyi Zhang, Haiyan Liu, Weibing Zhang. (2016) Preparation and evaluation of 3 m open tubular capillary columns with a zwitterionic polymeric porous layer for liquid chromatography. JOURNAL OF SEPARATION SCIENCE, 39 (19): (3736-3744). [PMID:27511867] [10.1002/jssc.201600535]
15. Bin Guo, Xu-Ran Fan, Zhong-Ze Fang, Yun-Feng Cao, Cui-Min Hu, Julin Yang, Yan-Yan Zhang, Rong-Rong He, Xu Zhu, Zhen-Wen Yu, Xiao-Yu Sun, Mo Hong, Lu Yang. (2012) Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. PHYTOTHERAPY RESEARCH, 27 (8): (1232-1236). [PMID:23065713] [10.1002/ptr.4855]
16. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044]

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Liquiritin - ≥98% (HPLC) ,from Glycyrrhizae root (licorice root), high purity , CAS No.551-15-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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