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Lisinopril Dihydrate - ≥98%, high purity , Angiotensin-converting enzyme inhibitor, CAS No.83915-83-7, Angiotensin-converting enzyme inhibitor

  • ≥98%
Item Number
L129324
Grouped product items
SKUSizeAvailabilityPrice Qty
L129324-1g
1g
In stock
$107.90
L129324-5g
5g
In stock
$246.90
L129324-25g
25g
In stock
$1,111.90
L129324-100g
100g
In stock
$4,001.90

Potent, competitive ACE inhibitor

Basic Description

SynonymsLisinopril dihydrate|83915-83-7|Renacor|Ranolip|Lisinopril hydrate|Lisinopril (dihydrate)|MK-521|CHEBI:6503|E7199S1YWR|DTXSID2045600|UNII-E7199S1YWR|1-(N(sup 2)-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline dihydrate|NCGC00017141-01|CAS-83915-83-7|Zes
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAngiotensin converting enzyme (ACE) inhibitor.Potent, competitive angiotensin converting enzyme inhibitor (IC 50 = 4 nM). Cardiotonic and antihypertensive effects. Orally active. Poor blood-brain barrier permeability. Active in vitro and in vivo .
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionAngiotensin-converting enzyme inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Lisinopril is an angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
INCHI InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChi Key CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
Canonical SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
Isomeric SMILES C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
WGK Germany 3
RTECS TW3589990
PubChem CID 5362118
Molecular Weight 405.49(as Anhydrous)
Reaxy-Rn 4276619

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot NumberCertificate TypeDateItem
G1516060Certificate of AnalysisJan 10, 2023 L129324
K2225579Certificate of AnalysisAug 16, 2022 L129324
K2225620Certificate of AnalysisAug 16, 2022 L129324
K2225644Certificate of AnalysisAug 16, 2022 L129324

Chemical and Physical Properties

SolubilityDMSO Water 20 mg/mL Ethanol
SensitivityHeat sensitive
Specific Rotation[α]-45° (C=1,0.25mol/L ZnAcetate Buff. sol.)
Melt Point(°C)148°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS TW3589990
Reaxy-Rn 4276619
Merck Index 5516

Related Documents

Solution Calculators