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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L129324-1g | 1g | In stock | $107.90 | |
L129324-5g | 5g | In stock | $246.90 | |
L129324-25g | 25g | In stock | $1,111.90 | |
L129324-100g | 100g | In stock | $4,001.90 |
Potent, competitive ACE inhibitor
Synonyms | MK-521 | LISINOPRIL COMPONENT OF PRINZIDE | LISINOPRIL [USAN] | Prestwick_613 | (S)-Lisinopril | AC-6226 | UNII-E7199S1YWR | DTXSID7041253 | Lisinopril, United States Pharmacopeia (USP) Reference Standard | (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)- |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Angiotensin converting enzyme (ACE) inhibitor.Potent, competitive angiotensin converting enzyme inhibitor (IC 50 = 4 nM). Cardiotonic and antihypertensive effects. Orally active. Poor blood-brain barrier permeability. Active in vitro and in vivo . |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Action Type | INHIBITOR |
Mechanism of action | Angiotensin-converting enzyme inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Lisinopril is an angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. |
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IUPAC Name | (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate |
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INCHI | InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1 |
InChi Key | CZRQXSDBMCMPNJ-ZUIPZQNBSA-N |
Canonical SMILES | C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O |
Isomeric SMILES | C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O |
WGK Germany | 3 |
RTECS | TW3589990 |
PubChem CID | 5362118 |
Molecular Weight | 405.49(as Anhydrous) |
Reaxy-Rn | 4276619 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G1516060 | Certificate of Analysis | Jan 10, 2023 | L129324 |
K2225579 | Certificate of Analysis | Aug 16, 2022 | L129324 |
K2225620 | Certificate of Analysis | Aug 16, 2022 | L129324 |
K2225644 | Certificate of Analysis | Aug 16, 2022 | L129324 |
Solubility | DMSO Water 20 mg/mL Ethanol |
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Sensitivity | Heat sensitive |
Specific Rotation[α] | -45° (C=1,0.25mol/L ZnAcetate Buff. sol.) |
Melt Point(°C) | 148°C |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | TW3589990 |
Reaxy-Rn | 4276619 |
Merck Index | 5516 |
1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu. (2022) A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1195 (123203). [PMID:35248900] |
1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu. (2022) A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1195 (123203). [PMID:35248900] |