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Lisinopril Dihydrate - ≥98%, high purity , Angiotensin-converting enzyme inhibitor, CAS No.83915-83-7, Angiotensin-converting enzyme inhibitor

1 Citations

≥98%

CAS#: 83915-83-7
Formula: C₂₁H₃₁N₃O₅· 2H₂O
Molecular Weight: 405.49(as Anhydrous)
MDL number: MFCD01698825
PubChem CID: 5362118

Item Number

L129324

Grouped product items
SKU	Size	Availability	Price
L129324-1g	1g	In stock	$107.90
L129324-5g	5g	In stock	$246.90
L129324-25g	25g	In stock	$1,111.90
L129324-100g	100g	In stock	$4,001.90

Potent, competitive ACE inhibitor

View related series

Angiotensin-converting Enzyme (ACE) Five-Membered Heterocyclic Compounds Metabolic Enzyme/Protease proline

Basic Description

Synonyms	MK-521 \| LISINOPRIL COMPONENT OF PRINZIDE \| LISINOPRIL [USAN] \| Prestwick_613 \| (S)-Lisinopril \| AC-6226 \| UNII-E7199S1YWR \| DTXSID7041253 \| Lisinopril, United States Pharmacopeia (USP) Reference Standard \| (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Angiotensin converting enzyme (ACE) inhibitor.Potent, competitive angiotensin converting enzyme inhibitor (IC 50 = 4 nM). Cardiotonic and antihypertensive effects. Orally active. Poor blood-brain barrier permeability. Active in vitro and in vivo .
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Angiotensin-converting enzyme inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Lisinopril is an angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
INCHI	InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChi Key	CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
Canonical SMILES	C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
Isomeric SMILES	C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
WGK Germany	3
RTECS	TW3589990
PubChem CID	5362118
Molecular Weight	405.49(as Anhydrous)
Reaxy-Rn	4276619

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
K2225579	Certificate of Analysis	Sep 13, 2024	L129324
K2225620	Certificate of Analysis	Sep 13, 2024	L129324
K2225644	Certificate of Analysis	Sep 13, 2024	L129324
G1516060	Certificate of Analysis	Jan 10, 2023	L129324

Chemical and Physical Properties

Solubility	DMSO Water 20 mg/mL Ethanol
Sensitivity	Heat sensitive
Specific Rotation[α]	-45° (C=1,0.25mol/L ZnAcetate Buff. sol.)
Melt Point(°C)	148°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Danger
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	TW3589990
Reaxy-Rn	4276619
Merck Index	5516

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu. (2022) A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1195 (123203). [PMID:35248900] [10.1016/j.jchromb.2022.123203]

References

1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu. (2022) A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1195 (123203). [PMID:35248900] [10.1016/j.jchromb.2022.123203]

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