Lisinopril Dihydrate - ≥98%, high purity , Angiotensin-converting enzyme inhibitor, CAS No.83915-83-7, Angiotensin-converting enzyme inhibitor

1 Citations
  • ≥98%
Item Number
L129324
Grouped product items
SKUSizeAvailabilityPrice Qty
L129324-1g
1g
In stock
$107.90
L129324-5g
5g
In stock
$246.90
L129324-25g
25g
In stock
$1,111.90
L129324-100g
100g
In stock
$4,001.90

Potent, competitive ACE inhibitor

Basic Description

SynonymsMK-521 | LISINOPRIL COMPONENT OF PRINZIDE | LISINOPRIL [USAN] | Prestwick_613 | (S)-Lisinopril | AC-6226 | UNII-E7199S1YWR | DTXSID7041253 | Lisinopril, United States Pharmacopeia (USP) Reference Standard | (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAngiotensin converting enzyme (ACE) inhibitor.Potent, competitive angiotensin converting enzyme inhibitor (IC 50 = 4 nM). Cardiotonic and antihypertensive effects. Orally active. Poor blood-brain barrier permeability. Active in vitro and in vivo .
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionAngiotensin-converting enzyme inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Lisinopril is an angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

Associated Targets(Human)

ACE Tclin Angiotensin-converting enzyme (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid;dihydrate
INCHI InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1
InChi Key CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
Canonical SMILES C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
Isomeric SMILES C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
WGK Germany 3
RTECS TW3589990
PubChem CID 5362118
Molecular Weight 405.49(as Anhydrous)
Reaxy-Rn 4276619

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
G1516060Certificate of AnalysisJan 10, 2023 L129324
K2225579Certificate of AnalysisAug 16, 2022 L129324
K2225620Certificate of AnalysisAug 16, 2022 L129324
K2225644Certificate of AnalysisAug 16, 2022 L129324

Chemical and Physical Properties

SolubilityDMSO Water 20 mg/mL Ethanol
SensitivityHeat sensitive
Specific Rotation[α]-45° (C=1,0.25mol/L ZnAcetate Buff. sol.)
Melt Point(°C)148°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H373:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS TW3589990
Reaxy-Rn 4276619
Merck Index 5516

Related Documents

Citations of This Product

1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu.  (2022)  A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1195  (123203).  [PMID:35248900]

References

1. Hui Luo, Yin Qian, Jin Qi, Xinyu Liu.  (2022)  A novel strategy for screening angiotensin-converting enzyme inhibitors from natural products based on enzyme-immobilized ligand fishing combined with active-site blocking and directional enrichment.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1195  (123203).  [PMID:35248900]

Solution Calculators