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Lithocholic acid - >97.0%, high purity , CAS No.434-13-9, Agonist of Farnesoid X receptor;Agonist of GPBA receptor;Agonist of Pregnane X receptor;Agonist of Vitamin D receptor

  • Moligand™
  • ≥97%
Item Number
L106779
Grouped product items
SKUSizeAvailabilityPrice Qty
L106779-1g
1g
In stock
$64.90
L106779-5g
5g
In stock
$103.90
L106779-25g
25g
In stock
$468.90
L106779-100g
100g
In stock
$1,684.90

Basic Description

SynonymsLITHOCHOLIC ACID|434-13-9|Lithocolic acid|Lithocholate|3alpha-Hydroxy-5beta-cholan-24-oic acid|3alpha-Hydroxy-5beta-cholanic acid|3alpha-Hydroxycholanic acid|LITHOCHOLICACID|3-alpha-Hydroxycholanic acid|5beta-Cholanic acid-3alpha-ol|NCI-C03861|3-Hydroxych
Specifications & PurityMoligand™, ≥97%
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Farnesoid X receptor;Agonist of GPBA receptor;Agonist of Pregnane X receptor;Agonist of Vitamin D receptor

Associated Targets

C7orf77 Tdark Uncharacterized protein C7orf77 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EPHA2 Tclin Ephrin type-A receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR35 Tchem G-protein coupled receptor 35 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FFAR4 Tchem Free fatty acid receptor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SNCA Tchem Alpha-synuclein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TST Tchem Thiosulfate sulfurtransferase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1H4 Tclin Bile acid receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APLNR Tchem Apelin receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPBAR1 Tchem G-protein coupled bile acid receptor 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC10A2 Tclin Ileal sodium/bile acid cotransporter 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488181047
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181047
IUPAC Name (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
INCHI InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1
InChi Key SMEROWZSTRWXGI-HVATVPOCSA-N
Canonical SMILES CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
Isomeric SMILES C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C
WGK Germany 2
RTECS FZ2275000
PubChem CID 9903
Molecular Weight 376.57
Beilstein 3217757

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

20 results found

Lot NumberCertificate TypeDateItem
G2431271Certificate of AnalysisJul 22, 2024 L106779
G2431270Certificate of AnalysisJul 22, 2024 L106779
G2431269Certificate of AnalysisJul 22, 2024 L106779
K2316404Certificate of AnalysisNov 09, 2023 L106779
K2316403Certificate of AnalysisNov 09, 2023 L106779
K2316281Certificate of AnalysisNov 09, 2023 L106779
K2316280Certificate of AnalysisNov 09, 2023 L106779
K2316279Certificate of AnalysisNov 09, 2023 L106779
K2316278Certificate of AnalysisNov 09, 2023 L106779
K2316277Certificate of AnalysisNov 09, 2023 L106779
G2422470Certificate of AnalysisNov 09, 2023 L106779
F2329306Certificate of AnalysisMar 03, 2023 L106779
C2315544Certificate of AnalysisMar 03, 2023 L106779
C2314349Certificate of AnalysisMar 03, 2023 L106779
C2314348Certificate of AnalysisMar 03, 2023 L106779
C2314345Certificate of AnalysisMar 03, 2023 L106779
C2314343Certificate of AnalysisMar 03, 2023 L106779
C2314336Certificate of AnalysisMar 03, 2023 L106779
C2314333Certificate of AnalysisMar 03, 2023 L106779
C2314325Certificate of AnalysisMar 03, 2023 L106779

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Chemical and Physical Properties

Specific Rotation[α]35.5°
Melt Point(°C)183-188°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 2
RTECS FZ2275000

Related Documents

References

1. Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S et al..  (2013)  Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor..  J Med Chem,  56  (7): (2936-47).  [PMID:23489211]
2. Wang XY, Zhang SY, Li J, Liu HN, Xie X, Nan FJ.  (2014)  Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy..  Acta Pharmacol Sin,  35  (11): (1463-72).  [PMID:25283506]
3. Alan F Hofmann.  (2004-11-24)  Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity..  Drug metabolism reviews,  36  ((3-4)): (703-722).  [PMID:15554243]
4. Gregory C Stachelek,Shibani Dalal,Katherine A Donigan,Denise Campisi Hegan,Joann B Sweasy,Peter M Glazer.  (2009-12-24)  Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation..  Cancer research,  70  ((1)): (409-417).  [PMID:20028873]
5. José João Carvalho,Maria Astrid Walter,Yvonne Baermann-Stapel,Michael G Weller,Ulrich Panne,Jörg A Schenk,Rudolf J Schneider.  (2012-01-03)  Non-invasive monitoring of immunization progress in mice via IgG from feces..  In vivo (Athens, Greece),  26  ((1)): (63-69).  [PMID:22210717]
6. Shinji Sato,Hidenari Nagai,Yoshinori Igarashi.  (2012-03-01)  Effect of probiotics on serum bile acids in patients with ulcerative colitis..  Hepato-gastroenterology,  59  ((118)): (1804-1808).  [PMID:22369744]
7. Makoto Ishii,Takahiro Toda,Nobutomo Ikarashi,Wataru Ochiai,Kiyoshi Sugiyama.  (2012-03-03)  [Effects of intestinal flora on the expression of cytochrome P450 3A in the liver]..  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,  132  ((3)): (301-310).  [PMID:22382834]
8. Nathalie Ménard,Nicolas Tsapis,Cécile Poirier,Thomas Arnauld,Laurence Moine,Claire Gignoux,François Lefoulon,Jean-Manuel Péan,Elias Fattal.  (2012-03-28)  Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies..  Pharmaceutical research,  29  ((7)): (1882-1896).  [PMID:22451248]
9. Henri Duboc,Hélène Aelion,Dominique Rainteau,Sylvie Rajca,Harry Sokol,Lydie Humbert,Dominique Farabos,Benoit Coffin,Simon Weber,Raphaël Porcher,Olivier Varenne,Denis Duboc.  (2012-05-19)  Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor?.  Hepatology (Baltimore, Md.),  56  ((6)): (2426-2426).  [PMID:22605482]
10. Michelle T Burstein,Pavlo Kyryakov,Adam Beach,Vincent R Richard,Olivia Koupaki,Alejandra Gomez-Perez,Anna Leonov,Sean Levy,Forough Noohi,Vladimir I Titorenko.  (2012-08-17)  Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan..  Cell cycle (Georgetown, Tex.),  11  ((18)): (3443-3462).  [PMID:22894934]
11. Yu-Guang Wang,Jian-Ming Zhou,Zeng-Chun Ma,Hua Li,Qian-De Liang,Hong-Ling Tan,Cheng-Rong Xiao,Bo-Li Zhang,Yue Gao.  (2012-09-18)  Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury..  Chemico-biological interactions,  200  ((1)): (11-20).  [PMID:22982774]
12. Shasha Song,Lei Feng,Aixin Song,Jingcheng Hao.  (2012-10-03)  Room-temperature super hydrogel as dye adsorption agent..  The journal of physical chemistry. B,  116  ((42)): (12850-12856).  [PMID:23025583]
13. Satu Strandman,Frantz Le Dévédec,X X Zhu.  (2012-12-12)  Self-assembly of bile acid-PEG conjugates in aqueous solutions..  The journal of physical chemistry. B,  117  ((1)): (252-258).  [PMID:23215002]
14. V V Kollerov,D Monti,N O Deshcherevskaya,T G Lobastova,E E Ferrandi,A Larovere,S A Gulevskaya,S Riva,M V Donova.  (2013-01-22)  Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi..  Steroids,  78  ((3)): (370-378).  [PMID:23333587]
15. Vedagopuram Sreekanth,Avinash Bajaj.  (2013-02-07)  Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid-drug conjugates with model membranes..  The journal of physical chemistry. B,  117  ((7)): (2123-2133).  [PMID:23383746]
16. Anna N Bukiya,Jacob E McMillan,Alexander L Fedinec,Shivaputra A Patil,Duane D Miller,Charles W Leffler,Abby L Parrill,Alex M Dopico.  (2013-03-05)  Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel β1-subunit by a novel nonsteroidal agent..  Molecular pharmacology,  83  ((5)): (1030-1044).  [PMID:23455312]
17. Manish Singh,Ashima Singh,Somanath Kundu,Sandhya Bansal,Avinash Bajaj.  (2013-04-18)  Deciphering the role of charge, hydration, and hydrophobicity for cytotoxic activities and membrane interactions of bile acid based facial amphiphiles..  Biochimica et biophysica acta,  1828  ((8)): (1926-1937).  [PMID:23590996]
18. Benjamin L Woolbright,Feng Li,Yuchao Xie,Anwar Farhood,Peter Fickert,Michael Trauner,Hartmut Jaeschke.  (2014-04-20)  Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice..  Toxicology letters,  228  ((1)): (56-66).  [PMID:24742700]
19. Marine Baptissart,Aurélie Vega,Emmanuelle Martinot,Aurélien J Pommier,Sander M Houten,Geoffroy Marceau,Angélique de Haze,Silvère Baron,Kristina Schoonjans,Jean-Marc A Lobaccaro,David H Volle.  (2014-05-07)  Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice..  Hepatology (Baltimore, Md.),  60  ((3)): (1054-1065).  [PMID:24798773]
20. Susan A Joyce,John MacSharry,Patrick G Casey,Michael Kinsella,Eileen F Murphy,Fergus Shanahan,Colin Hill,Cormac G M Gahan.  (2014-05-07)  Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut..  Proceedings of the National Academy of Sciences of the United States of America,  111  ((20)): (7421-7426).  [PMID:24799697]
21. Antonella Napolitano,Sam Miller,Andrew W Nicholls,David Baker,Stephanie Van Horn,Elizabeth Thomas,Deepak Rajpal,Aaron Spivak,James R Brown,Derek J Nunez.  (2014-07-06)  Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus..  PloS one,  ((7)): (e100778-e100778).  [PMID:24988476]
22. Maria C Estiú,Maria J Monte,Laura Rivas,Maria Moirón,Laura Gomez-Rodriguez,Tomas Rodriguez-Bravo,Jose J G Marin,Rocio I R Macias.  (2014-08-08)  Effect of ursodeoxycholic acid treatment on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy..  British journal of clinical pharmacology,  79  ((2)): (316-329).  [PMID:25099365]
23. Jing-Chun Han,Jian Yu,Ya-Jie Gao.  (2014-10-08)  Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles..  Pharmaceutical biology,  52  ((12)): (1624-1628).  [PMID:25289528]
24. Nianbai Fang,Shanggong Yu,Martin Jj Ronis,Thomas M Badger.  (2014-10-12)  Matrix effects break the LC behavior rule for analytes in LC-MS/MS analysis of biological samples..  Experimental biology and medicine (Maywood, N.J.),  240  ((4)): (488-497).  [PMID:25304311]
25. Isabel Veloso Alves Pereira,Bettina Buchmann,Lisa Sandmann,Kathrin Sprinzl,Verena Schlaphoff,Katinka Döhner,Florian Vondran,Christoph Sarrazin,Michael P Manns,Cláudia Pinto Marques Souza de Oliveira,Beate Sodeik,Sandra Ciesek,Thomas von Hahn.  (2015-02-04)  Primary biliary acids inhibit hepatitis D virus (HDV) entry into human hepatoma cells expressing the sodium-taurocholate cotransporting polypeptide (NTCP)..  PloS one,  10  ((2)): (e0117152-e0117152).  [PMID:25646622]
26. Nomundelger Gankhuyag,Bijay Singh,Sushila Maharjan,Yun-Jaie Choi,Chong-Su Cho,Myung-Haing Cho.  (2015-02-07)  Galactosylated poly(ethyleneglycol)-lithocholic Acid selectively kills hepatoma cells, while sparing normal liver cells..  Macromolecular bioscience,  15  ((6)): (777-787).  [PMID:25657071]
27. Yuan Chen,Alex Vasilenko,Xiulong Song,Leila Valanejad,Ruchi Verma,Sangmin You,Bingfang Yan,Stephanie Shiffka,Leeza Hargreaves,Christina Nadolny,Ruitang Deng.  (2015-02-13)  Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump..  Molecular endocrinology (Baltimore, Md.),  29  ((4)): (613-626).  [PMID:25675114]
28. Limin Zhang,Robert G Nichols,Jared Correll,Iain A Murray,Naoki Tanaka,Philip B Smith,Troy D Hubbard,Aswathy Sebastian,Istvan Albert,Emmanuel Hatzakis,Frank J Gonzalez,Gary H Perdew,Andrew D Patterson.  (2015-03-15)  Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation..  Environmental health perspectives,  123  ((7)): (679-688).  [PMID:25768209]
29. Xiaoyan Chu,Shian-Jiun Shih,Rachel Shaw,Hannes Hentze,Grace H Chan,Karen Owens,Shubing Wang,Xiaoxin Cai,Deborah Newton,Jose Castro-Perez,Gino Salituro,Jairam Palamanda,Aaron Fernandis,Choon Keow Ng,Andy Liaw,Mary J Savage,Raymond Evers.  (2015-03-31)  Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans..  Drug metabolism and disposition: the biological fate of chemicals,  43  ((6)): (851-863).  [PMID:25813937]
30. Adam Beach,Vincent R Richard,Simon Bourque,Tatiana Boukh-Viner,Pavlo Kyryakov,Alejandra Gomez-Perez,Anthony Arlia-Ciommo,Rachel Feldman,Anna Leonov,Amanda Piano,Veronika Svistkova,Vladimir I Titorenko.  (2015-04-04)  Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome..  Cell cycle (Georgetown, Tex.),  14  ((11)): (1643-1656).  [PMID:25839782]
31. Haiqiao Wang,Shasha Song,Jingcheng Hao,Aixin Song.  (2015-07-17)  Hydrogels Triggered by Metal Ions as Precursors of Network CuS for DNA Detection..  Chemistry (Weinheim an der Bergstrasse, Germany),  21  ((34)): (12194-12201).  [PMID:26179250]
32. Claudiu Saracut,Calin Molnar,Cristian Russu,Nicoleta Todoran,Laurian Vlase,Sabin Turdean,Septimiu Voidazan,Constantin Copotoiu.  (2015-10-16)  Secondary bile acids effects in colon pathology. Experimental mice study..  Acta cirurgica brasileira,  30  ((9)): (624-631).  [PMID:26465107]
33. Katarzyna Magiera,Marcin Tomala,Katarzyna Kubica,Virginia De Cesare,Matthias Trost,Bartosz J Zieba,Neli Kachamakova-Trojanowska,Marcin Les,Grzegorz Dubin,Tad A Holak,Lukasz Skalniak.  (2017-03-28)  Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a..  Cell chemical biology,  24  ((4)): (458-470).  [PMID:28343940]
34. Wycliffe O Masanta,Andreas E Zautner,Raimond Lugert,Wolfgang Bohne,Uwe Gross,Andreas Leha,Mohammed Dakna,Christof Lenz.  (2018-09-25)  Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids..  Proteomics. Clinical applications,  13  ((3)): (e1800083-e1800083).  [PMID:30246935]
35. Vishal Singh,Beng San Yeoh,Benoit Chassaing,Xia Xiao,Piu Saha,Rodrigo Aguilera Olvera,John D Lapek,Limin Zhang,Wei-Bei Wang,Sijie Hao,Michael D Flythe,David J Gonzalez,Patrice D Cani,Jose R Conejo-Garcia,Na Xiong,Mary J Kennett,Bina Joe,Andrew D Patterson,Andrew T Gewirtz,Matam Vijay-Kumar.  (2018-10-20)  Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer..  Cell,  175  ((3)): (679-694).  [PMID:30340040]
36. Yunjing Zhang,Runqiu Jiang,Xiaojiao Zheng,Sha Lei,Fengjie Huang,Guoxiang Xie,Sandi Kwee,Herbert Yu,Christine Farrar,Beicheng Sun,Aihua Zhao,Wei Jia.  (2019-05-12)  Ursodeoxycholic acid accelerates bile acid enterohepatic circulation..  British journal of pharmacology,  176  ((16)): (2848-2863).  [PMID:31077342]
37. Kent A Willis,Charles K Gomes,Prahlad Rao,Dejan Micic,E Richard Moran,Erin Stephenson,Michelle Puchowicz,Qusai Al Abdallah,Tahliyah S Mims,Ankush Gosain,Dengping Yin,Ajay J Talati,Eugene B Chang,Joan C Han,Joseph F Pierre.  (2020-01-07)  TGR5 signaling mitigates parenteral nutrition-associated liver disease..  American journal of physiology. Gastrointestinal and liver physiology,  318  ((2)): (G322-G335).  [PMID:31905022]
38. Mao Taketani,Jianbo Zhang,Shuyi Zhang,Alexander J Triassi,Yu-Ja Huang,Linda G Griffith,Christopher A Voigt.  (2020-04-02)  Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron..  Nature biotechnology,  38  ((8)): (962-969).  [PMID:32231334]
39. Jingyi Hu,Hai Huang,Yuan Che,Chujie Ding,Lu Zhang,Yun Wang,Haiping Hao,Hong Shen,Lijuan Cao.  (2020-09-18)  Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function..  Journal of ethnopharmacology,  266  (113394-113394).  [PMID:32941971]
40. Jeffrey R Maslanka,Christopher H Gu,Isma Zarin,Joshua E Denny,Susan Broadaway,Bryton Fett,Lisa M Mattei,Seth T Walk,Michael C Abt.  (2020-12-12)  Detection and elimination of a novel non-toxigenic Clostridioides difficile strain from the microbiota of a mouse colony..  Gut microbes,  12  ((1)): (1-15).  [PMID:33305657]
41. Sean T Koester,Naisi Li,Daniel M Lachance,Neelendu Dey.  (2021-11-23)  Marker-based assays for studying gut transit in gnotobiotic and conventional mouse models..  STAR protocols,  ((4)): (100938-100938).  [PMID:34806048]
42. J E King,L J Schoenfield.  (1972-10-01)  Lithocholic acid, cholestasis, and liver disease..  Mayo Clinic proceedings,  47  ((10)): (725-730).  [PMID:4564415]
43. Masayuki Chuma,Kaori Endo-Umeda,Shigeki Shimba,Sachiko Yamada,Makoto Makishima.  (2012-04-03)  Hairless modulates ligand-dependent activation of the vitamin D receptor-retinoid X receptor heterodimer..  Biological & pharmaceutical bulletin,  35  ((4)): (582-587).  [PMID:22466564]
44. D Epstein,K Mistry,A Whitelaw,G Watermeyer,K E Pettengell.  (2012-06-07)  The effect of physiological concentrations of bile acids on in vitro growth of Mycobacterium tuberculosis..  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,  102  ((6)): (522-524).  [PMID:22668954]
45. J Jehle,I Staudacher,F Wiedmann,Pa Schweizer,R Becker,Ha Katus,D Thomas.  (2012-08-01)  Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid..  British journal of pharmacology,  167  ((7)): (1563-1572).  [PMID:22845314]
46. Tsutomu Matsubara,Naoki Tanaka,Misako Sato,Dong Wook Kang,Kristopher W Krausz,Kathleen C Flanders,Kazuo Ikeda,Hans Luecke,Lalage M Wakefield,Frank J Gonzalez.  (2012-10-05)  TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury..  Journal of lipid research,  53  ((12)): (2698-2707).  [PMID:23034213]
47. Simon M Vogel,Matthias R Bauer,Andreas C Joerger,Rainer Wilcken,Tobias Brandt,Dmitry B Veprintsev,Trevor J Rutherford,Alan R Fersht,Frank M Boeckler.  (2012-10-05)  Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2..  Proceedings of the National Academy of Sciences of the United States of America,  109  ((42)): (16906-16910).  [PMID:23035244]
48. Farzad Alemi,Daniel P Poole,Jonathan Chiu,Kristina Schoonjans,Fiore Cattaruzza,John R Grider,Nigel W Bunnett,Carlos U Corvera.  (2012-10-09)  The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice..  Gastroenterology,  144  ((1)): (145-154).  [PMID:23041323]
49. Hai-Bing He,Li-Xin Gao,Qi-Feng Deng,Wei-Ping Ma,Chun-Lan Tang,Wen-Wei Qiu,Jie Tang,Jing-Ya Li,Jia Li,Fan Yang.  (2012-10-17)  Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B..  Bioorganic & medicinal chemistry letters,  22  ((23)): (7237-7242).  [PMID:23067554]
50. Valeria Tripodi,Mario Contin,María Alejandra Fernández,Abraham Lemberg.  (2012-11-01)  Bile acids content in brain of common duct ligated rats..  Annals of hepatology,  11  ((6)): (930-934).  [PMID:23111582]
51. Tanmay Bera,Jiyu Fang.  (2012-12-21)  Optical detection of lithocholic acid with liquid crystal emulsions..  Langmuir : the ACS journal of surfaces and colloids,  29  ((1)): (387-392).  [PMID:23252423]
52. Can Peng,Jixin Tian,Mengying Lv,Yin Huang,Yuan Tian,Zunjian Zhang.  (2013-01-15)  Development and validation of a sensitive LC-MS-MS method for the simultaneous determination of multicomponent contents in artificial Calculus Bovis..  Journal of chromatographic science,  52  ((2)): (128-136).  [PMID:23315150]
53. Yukako Okazaki,Zaki Utama,Sofya Suidasari,Peipei Zhang,Noriyuki Yanaka,Hiroyuki Tomotake,Ei Sakaguchi,Norihisa Kato.  (2013-01-19)  Consumption of vitamin B(6) reduces fecal ratio of lithocholic acid to deoxycholic acid, a risk factor for colon cancer, in rats fed a high-fat diet..  Journal of nutritional science and vitaminology,  58  ((5)): (366-370).  [PMID:23327973]
54. Vincent R Richard,Anna Leonov,Adam Beach,Michelle T Burstein,Olivia Koupaki,Alejandra Gomez-Perez,Sean Levy,Lukas Pluska,Sevan Mattie,Rami Rafesh,Tatiana Iouk,Sara Sheibani,Michael Greenwood,Hojatollah Vali,Vladimir I Titorenko.  (2013-04-05)  Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis..  Aging,  ((4)): (234-269).  [PMID:23553280]
55. Kyong Kim,Min Park,Yu Mi Lee,Mee Ra Rhyu,Hye Young Kim.  (2014-03-05)  Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation..  Archives of pharmacal research,  37  ((9)): (1193-1200).  [PMID:24590628]
56. Michael D Jones,Paul D Rainville,Giorgis Isaac,Ian D Wilson,Norman W Smith,Robert S Plumb.  (2014-05-13)  Ultra high resolution SFC-MS as a high throughput platform for metabolic phenotyping: application to metabolic profiling of rat and dog bile..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  966  (200-207).  [PMID:24815366]
57. Sweety Mathew,Susanne Krug,Thomas Skurk,Anna Halama,Antonia Stank,Anna Artati,Cornelia Prehn,Joel A Malek,Gabi Kastenmüller,Werner Römisch-Margl,Jerzy Adamski,Hans Hauner,Karsten Suhre.  (2014-06-08)  Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake..  Journal of translational medicine,  12  (161-161).  [PMID:24906381]
58. Yang Li,Bo Lin,Lei Yang.  (2015-05-23)  Comparative transcriptomic analysis of multiple cardiovascular fates from embryonic stem cells predicts novel regulators in human cardiogenesis..  Scientific reports,  (9758-9758).  [PMID:25997157]
59. Qin Lu,Youngchan Kim,Nabil Bassim,Greg E Collins.  (2015-05-26)  Impact of confinement on proteins concentrated in lithocholic acid based organic nanotubes..  Journal of colloid and interface science,  454  (97-104).  [PMID:26004574]
60. Namrata Singh,Debasish Bhattacharyya.  (2016-10-21)  Cholesterol and Its Derivatives Reversibly Inhibit Proteinase K..  Journal of cellular physiology,  232  ((3)): (596-609).  [PMID:27302018]
61. Giovanni Sorrentino,Alessia Perino,Ece Yildiz,Gaby El Alam,Maroun Bou Sleiman,Antimo Gioiello,Roberto Pellicciari,Kristina Schoonjans.  (2020-06-03)  Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration..  Gastroenterology,  159  ((3)): (956-968).  [PMID:32485177]

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