LJH685 - 10mM in DMSO, high purity , CAS No.1627710-50-2

Item Number

L421986

• Synonyms: LJH685 | 1627710-50-2 | LJH-685 | 2,6-difluoro-4-[4-[4-(4-methylpiperazin-1-yl)phenyl]pyridin-3-yl]phenol | CHEMBL3604793 | 27CZQ807C1 | 2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol | Phenol, 2,6-difluoro-4-(4-(4-(4-methyl-1-piperazinyl)pheny
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

LJH685 LJH685 is a potent pan- RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.

Targets

RSK3 (Cell-free assay); RSK2 (Cell-free assay); RSK1 (Cell-free assay) 4 nM; 5 nM; 6 nM

In vitro

LJH685 modulates YB1 phosphorylation by potently and selectively inhibiting RSK in cells. In MAPK pathway–dependent cancer cell lines, LJH685 shows antiproliferative effects, and causes cell-cycle regulation and apoptosis induction.

Cell Research(from reference)

Cell lines：Calu6, NCI-H2122, NCI-H358, NCI-H727, NCI-H2087, SW620, SW480, HT29, Capan-2, MiaPaCa2, SW1990, Panc02.03, MDA-MB-231, A375, G361, Colo205, Malme3M, WM1799, WM983B and WM266-4 cells 

Concentrations：~100 μM 

Incubation Time：72 h