Basic Description

Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent pan-ribosomal S6 protein kinase (RSK) inhibitor (IC50values are 4 to 13 nM). Displays selectivity for RSK isoforms over other kinases. Inhibits RSK-dependent Y-box binding protein 1 (YB-1) phosphorylationin vitro. Suppresses growth of triple negati
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product Application： LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation

Associated Targets(Human)

RPS6KA1 Tchem Ribosomal protein S6 kinase alpha-1 (2 Activities)

Discover Target: RPS6KA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA2 Tchem Ribosomal protein S6 kinase alpha-2 (2 Activities)

Discover Target: RPS6KA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA3 Tchem Ribosomal protein S6 kinase alpha-3 (4 Activities)

Discover Target: RPS6KA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)

Discover Target: RPS6KA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 Activities)

Discover Target: RPS6KA6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA2 Tchem Ribosomal protein S6 kinase alpha 2 (2184 Activities)

Discover Target: RPS6KA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA3 Tchem Ribosomal protein S6 kinase alpha 3 (4284 Activities)

Discover Target: RPS6KA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rps6ka3 Ribosomal protein S6 kinase alpha-3 (39 Activities)

Discover Target: Rps6ka3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2,6-difluoro-4-[4-(4-morpholin-4-ylphenyl)pyridin-3-yl]phenol
INCHI	InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2
InChi Key	YUYJEQHNWKQNBT-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F
Isomeric SMILES	C1COCCN1C2=CC=C(C=C2)C3=C(C=NC=C3)C4=CC(=C(C(=C4)F)O)F
PubChem CID	118704762
Molecular Weight	368.38

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
H23031001	Certificate of Analysis	Jul 17, 2023	L287303
H23031004	Certificate of Analysis	Jul 17, 2023	L287303
H23031005	Certificate of Analysis	Jul 17, 2023	L287303
H23031006	Certificate of Analysis	Jul 17, 2023	L287303
H23031008	Certificate of Analysis	Jul 17, 2023	L287303
H23031022	Certificate of Analysis	Jul 17, 2023	L287303
H2303986	Certificate of Analysis	Jul 17, 2023	L287303
H2303987	Certificate of Analysis	Jul 17, 2023	L287303
H2303991	Certificate of Analysis	Jul 17, 2023	L287303
H2303993	Certificate of Analysis	Jul 17, 2023	L287303

Chemical and Physical Properties

Solubility	DMSO:10 mg/mL,warmed；H2O:Insoluble

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SKU	Size	Availability	Price
L287303-5mg	5mg	In stock	$177.90
L287303-10mg	10mg	In stock	$296.90
L287303-25mg	25mg	In stock	$652.90
L287303-50mg	50mg	In stock	$1,175.90
L287303-100mg	100mg	In stock	$1,959.90

LJI308 - ≥98%(HPLC), high purity , CAS No.1627709-94-7