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LLL12 , CAS No.1260247-42-4, Inhibitor of signal transducer and activator of transcription 3

CAS#: 1260247-42-4
PubChem CID: 46911017

Item Number

L611558

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SKU	Size	Availability	Price	Qty
L611558-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611558-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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signal transducer and activator of transcription 3 Inhibitor

Basic Description

Synonyms	9,10-Dihydro-5-hydroxy-9,10-dioxo-1-anthracenesulfonamide \| NCGC00345811-01 \| 5-hydroxy-9,10-dioxoanthracene-1-sulfonamide \| BDBM420304 \| HY-19536 \| LLL12 \| LLL-12 \| SCHEMBL12310760 \| 1260247-42-4 \| GTPL12267 \| CS-0015635 \| 5-hydroxy-9,10-dioxo-9,10-dihyd
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of signal transducer and activator of transcription 3

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (1 Activities)

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

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HT-29 (80576 Activities)

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MDA-MB-468 (9477 Activities)

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PANC-1 (6144 Activities)

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PC-3 (62116 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-BR-3 (5175 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

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U-87 MG (3946 Activities)

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HEL (6614 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPAC (93 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-hydroxy-9,10-dioxoanthracene-1-sulfonamide
INCHI	InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)
InChi Key	CQBHSRLUQDYPBU-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N
Isomeric SMILES	C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N
Alternate CAS	1260247-42-4
PubChem CID	46911017
MeSH Entry Terms	5-hydroxy-9,10-dioxo-anthracene-1-sulfonamide;LLL 12;LLL-12

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

References

1. Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D et al.. (2010) A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.. Neoplasia, 12 (1): (39-50). [PMID:20072652] [10.1021/op500134e]

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LLL12 , CAS No.1260247-42-4, Inhibitor of signal transducer and activator of transcription 3

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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