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LLL12 , CAS No.1260247-42-4, Inhibitor of signal transducer and activator of transcription 3

CAS#: 1260247-42-4
PubChem CID: 46911017

Item Number

L611558

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SKU	Size	Availability	Price	Qty
L611558-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611558-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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signal transducer and activator of transcription 3 Inhibitor

Basic Description

Synonyms	LLL12 \| LLL-12 \| 1260247-42-4 \| 5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide \| CHEMBL2380760 \| SCHEMBL12310760 \| GTPL12267 \| BDBM420304 \| DTXSID201194903 \| NCGC00345811-01 \| HY-19536 \| CS-0015635 \| 5-hydroxy-9,10-dioxoanthracene-1-sulfonamide \| 9,10-Dihydro-5-hydroxy-
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of signal transducer and activator of transcription 3

Associated Targets(Human)

STAT3 Tchem Signal transducer and activator of transcription 3 (1 Activities)

Discover Target: STAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)

Discover Target: STAT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-29 (80576 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-468 (9477 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PANC-1 (6144 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PC-3 (62116 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-BR-3 (5175 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-87 MG (3946 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEL (6614 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPAC (93 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-hydroxy-9,10-dioxoanthracene-1-sulfonamide
INCHI	InChI=1S/C14H9NO5S/c15-21(19,20)10-6-2-4-8-12(10)14(18)7-3-1-5-9(16)11(7)13(8)17/h1-6,16H,(H2,15,19,20)
InChi Key	CQBHSRLUQDYPBU-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N
Isomeric SMILES	C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C(=CC=C3)S(=O)(=O)N
Alternate CAS	1260247-42-4
PubChem CID	46911017
MeSH Entry Terms	5-hydroxy-9,10-dioxo-anthracene-1-sulfonamide;LLL 12;LLL-12

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

References

1. Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D et al.. (2010) A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.. Neoplasia, 12 (1): (39-50). [PMID:20072652]

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LLL12 , CAS No.1260247-42-4, Inhibitor of signal transducer and activator of transcription 3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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