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L463811-1mg

1mg

Available within 8-12 weeks(?)

$974.90

Basic Description

Synonyms	KBio3_002760 \| Spectrum3_001930 \| 2-Norbornanone, 1,3,3-trimethyl-, (1S,4R)-(+)- \| HY-N0513 \| Q19597767 \| Benzatropinum \| EINECS 244-875-9 \| Loganin acid \| Spectrum4_001690 \| 4,6-Diamino-2-pyrimidinethiol \| KBio2_004557 \| Loganic acid, >=95% (LC/MS-ELSD)
Specifications & Purity	≥95%(LC/MS-ELSD)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Description Loganic acid is a naturally occurring iridoid monoterpeneglusoside. It is a key constituent ofSwertia caroliniensis.Natural product derived from plant source.

Associated Targets(Human)

CD81 Tchem CD81 antigen (0 Activities)

Discover Target: CD81

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 (0 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (0 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CD81 Tchem CD81 antigen (15 Activities)

Discover Target: CD81

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hepatitis C virus (23859 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid
INCHI	InChI=1S/C16H24O10/c1-5-8(18)2-6-7(14(22)23)4-24-15(10(5)6)26-16-13(21)12(20)11(19)9(3-17)25-16/h4-6,8-13,15-21H,2-3H2,1H3,(H,22,23)/t5-,6+,8-,9+,10+,11+,12-,13+,15-,16-/m0/s1
InChi Key	JNNGEAWILNVFFD-CDJYTOATSA-N
Canonical SMILES	CC1C(CC2C1C(OC=C2C(=O)O)OC3C(C(C(C(O3)CO)O)O)O)O
Isomeric SMILES	C[C@H]1[C@H](C[C@H]2[C@@H]1[C@@H](OC=C2C(=O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O
PubChem CID	89640
Molecular Weight	376.36

Certificates

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References

1. M P Arvy,N Imbault,F Naudascher,M Thiersault,P Doireau. (1994-01-01) 2,4-D and alkaloid accumulation in periwinkle cell suspensions.. Biochimie, 76 ((5)): (410-416). [PMID:7849107]
2. J Suomi,S K Wiedmer,M Jussila,M L Riekkola. (2001-08-25) Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique.. Electrophoresis, 22 ((12)): (2580-2587). [PMID:11519962]
3. Pengeheng Lin,Zhaohui Ye,Yongchan Lu,Suqin Zhao,Fengzu Hu,Lanju Ji. (2005-04-07) [Content determination of loganic acid and gentiopicroside in Tebitan herbal medicines Gentiana macrophylla and G. straminea by HPLC].. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 27 ((11)): (819-821). [PMID:15810586]
4. Wen-Long Li,Jun-Hui Chen,Yue-Fen Yin,Feng-Qi Wu,Bai-Juan Yang,Huang-Hao Yang,Xiao-Ru Wang. (2007-08-21) [Content of gentiopicroside and loganic acid in Radix gentianae and their fingerprints].. Yao xue xue bao = Acta pharmaceutica Sinica, 42 ((5)): (566-570). [PMID:17703785]
5. Jun Murata,Jonathon Roepke,Heather Gordon,Vincenzo De Luca. (2008-03-11) The leaf epidermome of Catharanthus roseus reveals its biochemical specialization.. The Plant cell, 20 ((3)): (524-542). [PMID:18326827]
6. Quan-Bin Han,Song-Lin Li,Chun-Feng Qiao,Jing-Zheng Song,Zong-Wei Cai,Paul Pui-Hay But,Pang-Chui Shaw,Hong-Xi Xu. (2008-05-20) A simple method to identify the unprocessed Strychnos seeds used in herbal medicinal products.. Planta medica, 74 ((4)): (458-463). [PMID:18484543]
7. Hong-Peng Yang,Sheng Que,Xi-Dong Wu,Yan-Ping Shi. (2009-01-20) [Studies on glycosides from Gentiana veitchiorum].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 33 ((21)): (2505-2507). [PMID:19149260]
8. Anita Aberham,Valerio Pieri,Edward M Croom,Ernst Ellmerer,Hermann Stuppner. (2010-11-06) Analysis of iridoids, secoiridoids and xanthones in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea using LC-MS and RP-HPLC.. Journal of pharmaceutical and biomedical analysis, 54 ((3)): (517-525). [PMID:21050691]
9. Meng-ying Sun,Xu Feng,Xing-hun Lin,Min Yin,Xing-zeng Zhao,Yu Chen,Yu Shan. (2011-08-10) [Studies on the chemical constituents from stems and leaves of Lonicera macranthoides].. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34 ((2)): (218-220). [PMID:21823476]
10. Qifang Pan,Quan Wang,Fang Yuan,Shihai Xing,Jingya Zhao,Young Hae Choi,Robert Verpoorte,Yuesheng Tian,Guofeng Wang,Kexuan Tang. (2012-08-24) Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics.. PloS one, 7 ((8)): (e43038-e43038). [PMID:22916202]
11. Tao Zhang,Bin Li,Li Chen,Jing-Jing Li,Shi-Jun Liu,Jun-Xing Dong. (2013-02-07) A novel lactone from Tripterospermum chinense.. Yao xue xue bao = Acta pharmaceutica Sinica, 47 ((11)): (1517-1520). [PMID:23387086]
12. Chun Yao Li,Alex L Leopold,Guy W Sander,Jacqueline V Shanks,Le Zhao,Susan I Gibson. (2013-10-09) The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway.. BMC plant biology, 13 (155-155). [PMID:24099172]
13. Emilie Dussossoy,Florence Bichon,Emilie Bony,Karine Portet,Pierre Brat,Fabrice Vaillant,Alain Michel,Patrick Poucheret. (2016-07-28) Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.).. Journal of ethnopharmacology, 192 (264-272). [PMID:27451258]
14. Tomasz Sozański,Alicja Z Kucharska,Andrzej Rapak,Dorota Szumny,Małgorzata Trocha,Anna Merwid-Ląd,Stanisław Dzimira,Tomasz Piasecki,Narcyz Piórecki,Jan Magdalan,Adam Szeląg. (2016-10-17) Iridoid-loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation.. Atherosclerosis, 254 (151-160). [PMID:27744131]
15. Jie Li,Ji Zhang,Yan-Li Zhao,Heng-Yu Huang,Yuan-Zhong Wang. (2018-01-10) Comprehensive Quality Assessment Based Specific Chemical Profiles for Geographic and Tissue Variation in. Frontiers in chemistry, 5 (125-125). [PMID:29312929]
16. Niki Mougiou,Fotini Trikka,Emmanouil Trantas,Filippos Ververidis,Antonios Makris,Anagnostis Argiriou,Konstantinos E Vlachonasios. (2018-05-14) Expression of hydroxytyrosol and oleuropein biosynthetic genes are correlated with metabolite accumulation during fruit development in olive, Olea europaea, cv. Koroneiki.. Plant physiology and biochemistry : PPB, 128 (41-49). [PMID:29753981]
17. Francisco Javier Leyva-Jiménez,Jesús Lozano-Sánchez,Isabel Borrás-Linares,David Arráez-Román,Antonio Segura-Carretero. (2018-05-29) Comparative study of conventional and pressurized liquid extraction for recovering bioactive compounds from Lippia citriodora leaves.. Food research international (Ottawa, Ont.), 109 (213-222). [PMID:29803444]
18. Trevor Kidd,Michael Lae Easson,Yang Qu,Vincenzo De Luca. (2019-01-07) Inter-organ transport of secologanin allows assembly of monoterpenoid indole alkaloids in a Catharanthus roseus mutant.. Phytochemistry, 159 (119-126). [PMID:30611871]
19. Ju Zeng,Bin Cheng,Yan Huang,Xiaorui Zhang,Chen Wang,Na Sun,Gang Liu,Xiaorui Cheng,Yongxiang Zhang,Wenxia Zhou. (2019-10-23) Active Fraction Combination from Liuwei Dihuang Decoction (LW-AFC) Alleviated the LPS-Induced Long-Term Potentiation Impairment and Glial Cells Activation in Hippocampus of Mice by Modulating Immune Responses.. Evidence-based complementary and alternative medicine : eCAM, 2019 (3040972-3040972). [PMID:31636681]
20. Song Zhang,Shou-Lang Geshang,Zuo-Ma Dawa,Yan Zhou,Shu-Lin Peng. (2007-07-21) [Studies on chemical constituents of Eriophyton wallichii].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32 ((9)): (824-826). [PMID:17639985]
21. Hongjie Zhang,Katharina Rothwangl,Andrew D Mesecar,Ali Sabahi,Lijun Rong,Harry H S Fong. (2009-11-13) Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.. Journal of natural products, 72 ((12)): (2158-2162). [PMID:19904996]
22. Shihu Wei,Haidong Chi,Hiroyuki Kodama,Guang Chen. (2012-03-16) Anti-inflammatory effect of three iridoids in human neutrophils.. Natural product research, 27 ((10)): (911-915). [PMID:22417122]
23. Tao Zhang,Jian Li,Bin Li,Li Chen,Hai-Long Yin,Shi-Jun Liu,Ying Tian,Jun-Xing Dong. (2012-10-24) Two novel secoiridoid glucosides from Tripterospermum chinense.. Journal of Asian natural products research, 14 ((12)): (1097-1102). [PMID:23088535]
24. Yun Wu,Yu Ai,Fenrong Wang,Wen Ma,Qiaoxia Bian,David Y-W Lee,Ronghua Dai. (2015-05-28) Simultaneous determination of four secoiridoid and iridoid glycosides in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a comparative pharmacokinetic study.. Biomedical chromatography : BMC, 30 ((2)): (97-104). [PMID:26014753]
25. Lili Xu,Tingting Sheng,Xiaolong Liu,Tong Zhang,Zhengtao Wang,Han Han. (2017-07-25) Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.. Journal of ethnopharmacology, 209 (91-99). [PMID:28734962]
26. Nannan Wang,Xiaoning Zhao,Yiran Li,Congcong Cheng,Jiaxin Huai,Kaishun Bi,Ronghua Dai. (2018-01-20) Identification of the absorbed components and metabolites of modified Huo Luo Xiao Ling Dan in rat plasma by UHPLC-Q-TOF/MS/MS.. Biomedical chromatography : BMC, 32 ((6)): (e4195-e4195). [PMID:29349790]
27. S Singh,S S Pandey,K Shanker,A Kalra. (2019-12-11) Endophytes enhance the production of root alkaloids ajmalicine and serpentine by modulating the terpenoid indole alkaloid pathway in Catharanthus roseus roots.. Journal of applied microbiology, 128 ((4)): (1128-1142). [PMID:31821696]
28. Jan Oszmiański,Aneta Wojdyło,Piotr Juszczyk,Paulina Nowicka. (2020-01-16) Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities.. Plants (Basel, Switzerland), 9 ((1)): [PMID:31936189]

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Loganic acid - ≥95% (LC/MS-ELSD), high purity , CAS No.22255-40-9