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Lomefloxacin hydrochloride - 98%, high purity , Bacterial DNA gyrase inhibitor, CAS No.98079-52-8, Bacterial DNA gyrase inhibitor

5 Citations

≥98%

CAS#: 98079-52-8
Formula: C₁₇H₁₉F₂N₃O₃· HCl
Molecular Weight: 387.81
MDL number: MFCD00214312
PubChem CID: 68624

Item Number

L103102

Grouped product items
SKU	Size	Availability	Price
L103102-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$18.90
L103102-5g	5g	In stock	$71.90
L103102-25g	25g	In stock	$216.90
L103102-100g	100g	In stock	$779.90

View related series

Anti-infection Antibiotic Bacterial Quinolone antibiotics

Basic Description

Synonyms	D00873 \| HMS1568P17 \| Lomefloxacin monohydrochloride \| Okacyn \| L 2906 \| SR-01000075959-5 \| Ny-198 \| SC-47111 \| SR-01000075959 \| Bareon \| CCRIS 2581 \| Lomefloxacin hydrochloride (Maxaquin) \| NCGC00016964-02 \| Tox21_110716_1 \| NCGC00094038-01 \| HY-B0455 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replicati
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Bacterial DNA gyrase inhibitor
Product Description	application： Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria.

Associated Targets(Human)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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HEK293 (82097 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Plasma (328 Activities)

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FTL Ferritin light chain (43324 Activities)

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nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
INCHI	InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
InChi Key	KXEBLAPZMOQCKO-UHFFFAOYSA-N
Canonical SMILES	CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Isomeric SMILES	CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
WGK Germany	3
RTECS	VB1997500
PubChem CID	68624
Molecular Weight	387.81
Reaxy-Rn	7506829

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
D1918003	Certificate of Analysis	Feb 08, 2023	L103102
A2403080	Certificate of Analysis	Dec 30, 2021	L103102
B2209280	Certificate of Analysis	Dec 30, 2021	L103102
B2209281	Certificate of Analysis	Dec 30, 2021	L103102
B2209283	Certificate of Analysis	Dec 30, 2021	L103102
B2209349	Certificate of Analysis	Dec 30, 2021	L103102

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	VB1997500
Reaxy-Rn	7506829
Merck Index	5562

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Guangli Li, Xiaoman Qi, Jingtao Wu, Xuan Wan, Tianyu Wang, Ying Liu, Yuwei Chen, Yonghui Xia. (2024) Highly stable electrochemical sensing platform for the selective determination of pefloxacin in food samples based on a molecularly imprinted-polymer-coated gold nanoparticle/black phosphorus nanocomposite. FOOD CHEMISTRY, 436 (137753). [PMID:37862994] [10.1016/j.foodchem.2023.137753]
2. Xiao-Bing Zheng, Sheng-Hong Liu, Bao-Ying Wen, Wei Peng, Hong-Mei Li, Murugavel Kathiresan, Yue-Jiao Zhang, Shang-Zhong Jin, Jian-Feng Li. (2023) Rapid detection and whole class control of quinolone antibiotics in pork based on surface-enhanced Raman spectroscopy. JOURNAL OF RAMAN SPECTROSCOPY, 54 (5): (468-476). [PMID:] [10.1002/jrs.6509]
3. Leliang Wu, Yiting Lin, Yimin Zhang, Peng Wang, Mingjun Ding, Minghua Nie, Caixia Yan, Shiyao Chen. (2021) Ca(OH)2-mediated activation of peroxymonosulfate for the degradation of bisphenol S. RSC Advances, 11 (53): (33626-33636). [PMID:35497526] [10.1039/D1RA05286A]
4. Xie Yizhen, Li Qiuyi, Qin Lulu, Zhou Xiaobin, Fan Yinming. (2021) Multi-templates surface molecularly imprinted polymer for simultaneous and rapid determination of sulfonamides and quinolones in water: effect of carbon-carbon double bond. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (39): (54950-54959). [PMID:34120285] [10.1007/s11356-021-14794-6]
5. Jiaxing Huang, Daguang Li, Ruobai Li, Qianxin Zhang, Tiansheng Chen, Haijin Liu, Yang Liu, Wenying Lv, Guoguang Liu. (2019) An efficient metal-free phosphorus and oxygen co-doped g-C3N4 photocatalyst with enhanced visible light photocatalytic activity for the degradation of fluoroquinolone antibiotics. CHEMICAL ENGINEERING JOURNAL, 374 (242). [PMID:] [10.1016/j.cej.2019.05.175]

References

1. H Pruul,P J McDonald. (1990-01-01) Lomefloxacin-induced modification of the kinetics of growth of gram-negative bacteria and susceptibility to phagocytic killing by human neutrophils.. The Journal of antimicrobial chemotherapy, 25 ((1)): (91-101). [PMID:2108116]
2. Yongnian Ni,Shan Du,Serge Kokot. (2009-08-18) Molecular spectroscopy and chemometrics: an analytical study of synergistic effects of drugs--interaction between fluoroquinolones and DNA.. The Analyst, 134 ((9)): (1840-1847). [PMID:19684908]
3. Edmond B Koker,Piotr J Bilski,Ann G Motten,Baozhong Zhao,Colin F Chignell,Yu-Ying He. (2010-05-25) Real-time visualization of photochemically induced fluorescence of 8-halogenated quinolones: lomefloxacin, clinafloxacin and Bay3118 in live human HaCaT keratinocytes.. Photochemistry and photobiology, 86 ((4)): (792-797). [PMID:20492567]
4. Hongyuan Yan,Hui Wang,Xinying Qin,Baomi Liu,Jingjing Du. (2010-09-11) Ultrasound-assisted dispersive liquid-liquid microextraction for determination of fluoroquinolones in pharmaceutical wastewater.. Journal of pharmaceutical and biomedical analysis, 54 ((1)): (53-57). [PMID:20828967]
5. H Vahedian-Movahed,M R Saberi,J Chamani. (2010-12-15) Comparison of binding interactions of lomefloxacin to serum albumin and serum transferrin by resonance light scattering and fluorescence quenching methods.. Journal of biomolecular structure & dynamics, 28 ((4)): (483-502). [PMID:21142219]
6. M I Davidov. (2011-04-20) [Treatment of prostatic adenoma with concomitant chronic bacterial prostatitis].. Urologiia (Moscow, Russia : 1999), ((1)): (21-28). [PMID:21500490]
7. Gandhimathi Muruganathan,Dhanya Kondayil Nair,Natarajan Bharathi,Thengungal Kochupapy Ravi. (2011-07-01) Interaction study of moxifloxacin and lomefloxacin with co-administered drugs.. Pakistan journal of pharmaceutical sciences, 24 ((3)): (339-343). [PMID:21715267]
8. Yan-Ni Yi,Gui-Rong Li,Yong-Sheng Wang,Yu-Zhen Zhou,Hui-Min Zhu. (2011-10-27) Simultaneous determination of norfloxacin and lomefloxacin in milk by first derivative synchronous fluorescence spectrometry using Al (III) as an enhancer.. Analytica chimica acta, 707 ((1-2)): (128-134). [PMID:22027129]
9. N A Nozdrachev,A I Neĭmark,B A Neĭmark. (2011-11-10) [Administration of vitaprost plus for prevention of infectious-inflammatory complications of transurethral prostatic resection in patients with prostatic adenoma].. Urologiia (Moscow, Russia : 1999), ((4)): (55-55). [PMID:22066244]
10. Sonia Soldevila,Francisco Bosca. (2012-07-27) Photoreactivity of fluoroquinolones: nature of aryl cations generated in water.. Organic letters, 14 ((15)): (3940-3943). [PMID:22831557]
11. Lihong Gao,Yali Shi,Wenhui Li,Jiemin Liu,Yaqi Cai. (2015-03-26) Occurrence and distribution of antibiotics in urban soil in Beijing and Shanghai, China.. Environmental science and pollution research international, 22 ((15)): (11360-11371). [PMID:25804657]
12. Matthias Metzger,Philip Ley,Manfred Sturm,Björn Meermann. (2019-03-09) Screening method for extractable organically bound fluorine (EOF) in river water samples by means of high-resolution-continuum source graphite furnace molecular absorption spectrometry (HR-CS GF MAS).. Analytical and bioanalytical chemistry, 411 ((19)): (4647-4660). [PMID:30848316]
13. Naphatsakorn Orachorn,Opas Bunkoed. (2019-06-17) A nanocomposite fluorescent probe of polyaniline, graphene oxide and quantum dots incorporated into highly selective polymer for lomefloxacin detection.. Talanta, 203 (261-268). [PMID:31202336]
14. Ruonan Guo,Yiliang Zhu,Xiuwen Cheng,Junjing Li,John C Crittenden. (2020-06-10) Efficient degradation of lomefloxacin by Co-Cu-LDH activating peroxymonosulfate process: Optimization, dynamics, degradation pathway and mechanism.. Journal of hazardous materials, 399 (122966-122966). [PMID:32516652]
15. Mohammed W Nassar,Khalid A Attia,Ahmed A Mohamed,Ragab A Said,Ahmed El-Olemy,Mohamed A Hasan. (2020-08-15) Validated Liquid Chromatography-Tandem Mass Spectroscopic Method for Simultaneous Determination of Certain Drugs Used in Cataract Surgery in Rabbit Aqueous Humor.. Journal of chromatographic science, 58 ((9)): (814-822). [PMID:32794561]
16. Yuanxia Lv,Xiaohuan Qin,Kun Hu,Yong Huang,Shulin Zhao. (2021-01-04) Hybrid MoS2/g-C3N4-assisted LDI mass spectrometry for rapid detection of small molecules and polyethylene glycols and direct determination\xa0of uric acid in complicated biological samples.. Mikrochimica acta, 188 ((1)): (5-5). [PMID:33389155]
17. Sabry M Attia. (2008-08-30) Abatement by naringin of lomefloxacin-induced genomic instability in mice.. Mutagenesis, 23 ((6)): (515-521). [PMID:18755759]
18. Maria Rambla-Alegre,Josep Esteve-Romero,Samuel Carda-Broch. (2009-10-27) Validation of a MLC method with fluorescence detection for the determination of quinolones in urine samples by direct injection.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877 ((31)): (3975-3981). [PMID:19854116]
19. I V Ryzhko,R I Tsuraeva,B I Anisimov,A V Trishina. (2010-01-08) [Efficacy of levofloxacin, lomefloxacin and moxifloxacin vs. other fluoroquinolones in experimental plague due to FI+ and FI- strains of Yersinia pestis in Albino mice].. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 54 ((5-6)): (37-40). [PMID:20052916]
20. María M Tavío,Virginia D Aquili,José B Poveda,Nuno T Antunes,Javier Sánchez-Céspedes,Jordi Vila. (2010-04-17) Quorum-sensing regulator sdiA and marA overexpression is involved in in vitro-selected multidrug resistance of Escherichia coli.. The Journal of antimicrobial chemotherapy, 65 ((6)): (1178-1186). [PMID:20395215]
21. Yiruhan,Qiao-Jun Wang,Ce-Hui Mo,Yan-Wen Li,Peng Gao,Yi-Ping Tai,Yan Zhang,Zhi-Li Ruan,Jia-Wei Xu. (2010-05-04) Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao.. Environmental pollution (Barking, Essex : 1987), 158 ((7)): (2350-2358). [PMID:20434248]
22. Joana Sousa,Gilberto Alves,Ana Fortuna,Angelina Pena,Celeste Lino,Amílcar Falcão. (2010-07-20) Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination of norfloxacin, lomefloxacin and ciprofloxacin in human plasma.. Biomedical chromatography : BMC, 25 ((5)): (535-541). [PMID:20641047]
23. Yoko Yoshihisa,Ayumi Honda,Qing-Li Zhao,Teruhiko Makino,Riichiro Abe,Kotaro Matsui,Hiroshi Shimizu,Yusei Miyamoto,Takashi Kondo,Tadamichi Shimizu. (2010-09-04) Protective effects of platinum nanoparticles against UV-light-induced epidermal inflammation.. Experimental dermatology, 19 ((11)): (1000-1006). [PMID:20812965]
24. Chen Liu,Venkateswarlu Nanaboina,Gregory V Korshin,Wenju Jiang. (2012-08-07) Spectroscopic study of degradation products of ciprofloxacin, norfloxacin and lomefloxacin formed in ozonated wastewater.. Water research, 46 ((16)): (5235-5246). [PMID:22863026]
25. Zohreh Sattar,Hediye Iranfar,Ahmad Asoodeh,Mohammad Reza Saberi,Mahboobeh Mazhari,Jamshidkhan Chamani. (2012-08-29) Interaction between holo transferrin and HSA-PPIX complex in the presence of lomefloxacin: an evaluation of PPIX aggregation in protein-protein interactions.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 97 (1089-1100). [PMID:22925987]
26. Luca Maria Chiesa,Maria Nobile,Sara Panseri,Francesco Arioli. (2017-05-31) Antibiotic use in heavy pigs: Comparison between urine and muscle samples from food chain animals analysed by HPLC-MS/MS.. Food chemistry, 235 (111-118). [PMID:28554614]
27. Guangli Li, Xiaoman Qi, Jingtao Wu, Xuan Wan, Tianyu Wang, Ying Liu, Yuwei Chen, Yonghui Xia. (2024) Highly stable electrochemical sensing platform for the selective determination of pefloxacin in food samples based on a molecularly imprinted-polymer-coated gold nanoparticle/black phosphorus nanocomposite. FOOD CHEMISTRY, 436 (137753). [PMID:37862994] [10.1016/j.foodchem.2023.137753]
28. Xiao-Bing Zheng, Sheng-Hong Liu, Bao-Ying Wen, Wei Peng, Hong-Mei Li, Murugavel Kathiresan, Yue-Jiao Zhang, Shang-Zhong Jin, Jian-Feng Li. (2023) Rapid detection and whole class control of quinolone antibiotics in pork based on surface-enhanced Raman spectroscopy. JOURNAL OF RAMAN SPECTROSCOPY, 54 (5): (468-476). [PMID:] [10.1002/jrs.6509]
29. Leliang Wu, Yiting Lin, Yimin Zhang, Peng Wang, Mingjun Ding, Minghua Nie, Caixia Yan, Shiyao Chen. (2021) Ca(OH)2-mediated activation of peroxymonosulfate for the degradation of bisphenol S. RSC Advances, 11 (53): (33626-33636). [PMID:35497526] [10.1039/D1RA05286A]
30. Xie Yizhen, Li Qiuyi, Qin Lulu, Zhou Xiaobin, Fan Yinming. (2021) Multi-templates surface molecularly imprinted polymer for simultaneous and rapid determination of sulfonamides and quinolones in water: effect of carbon-carbon double bond. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (39): (54950-54959). [PMID:34120285] [10.1007/s11356-021-14794-6]
31. Jiaxing Huang, Daguang Li, Ruobai Li, Qianxin Zhang, Tiansheng Chen, Haijin Liu, Yang Liu, Wenying Lv, Guoguang Liu. (2019) An efficient metal-free phosphorus and oxygen co-doped g-C3N4 photocatalyst with enhanced visible light photocatalytic activity for the degradation of fluoroquinolone antibiotics. CHEMICAL ENGINEERING JOURNAL, 374 (242). [PMID:] [10.1016/j.cej.2019.05.175]

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Lomefloxacin hydrochloride - 98%, high purity , Bacterial DNA gyrase inhibitor, CAS No.98079-52-8, Bacterial DNA gyrase inhibitor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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