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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L125047-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $86.90 | |
L125047-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $249.90 |
Potent MGMT inhibitor
Synonyms | NSC787251 | NSC-787251 | 6-(4-Bromothenyloxy)-7H-purin-2-amine | 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine | Lomeguatrib [INN] | S79265T71M | SMR004701339 | 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine | HY-13668 | Lomeguatrib, >=98% (HPLC) | |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Lomequartrib is an inhibitor of O6 methylguanin-DNA methyltransferase (MGMT) with an IC50 value of 0.009 μM in cell-free extracts from HeLa S3 cells.Potent O 6 -methylguanine-DNA methyltransferase (MGMT) inhibitor (IC 50 = 9 nM). Inhibits recombinant huma |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM. |
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IUPAC Name | 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine |
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INCHI | InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16) |
InChi Key | JUJPKFNFCWJBCX-UHFFFAOYSA-N |
Canonical SMILES | C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N |
Isomeric SMILES | C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N |
WGK Germany | 3 |
RTECS | UO7420000 |
PubChem CID | 3025944 |
Molecular Weight | 326.17 |
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Solubility | Soluble in DMSO (100 mM). |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | UO7420000 |