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Lomeguatrib - 98%, high purity , CAS No.192441-08-0

Item Number

L125047

Grouped product items
SKU	Size	Availability	Price	Qty
L125047-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$86.90
L125047-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$249.90

Potent MGMT inhibitor

Basic Description

Synonyms	Lomeguatrib\|192441-08-0\|PaTrin-2\|PaTrin 2\|6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine\|6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine\|CHEMBL339133\|6-((4-Bromo-2-thienyl)methoxyl)purin-2-amine\|2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine\|S792
Specifications & Purity	98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM. A monosaccharide-linked inhibitor of MGMT.

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
INCHI	InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChi Key	JUJPKFNFCWJBCX-UHFFFAOYSA-N
Canonical SMILES	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
Isomeric SMILES	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
WGK Germany	3
RTECS	UO7420000
PubChem CID	3025944
Molecular Weight	326.17

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Solubility	Soluble in DMSO (100 mM).

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	UO7420000

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