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Lomeguatrib - 98%, high purity , CAS No.192441-08-0

≥98%

CAS#: 192441-08-0
Formula: C₁₀H₈BrN₅OS
Molecular Weight: 326.17
MDL number: MFCD23703756
PubChem CID: 3025944

Item Number

L125047

Grouped product items
SKU	Size	Availability	Price	Qty
L125047-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$86.90
L125047-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$249.90

Potent MGMT inhibitor

Basic Description

Synonyms	Lomeguatrib \| 192441-08-0 \| PaTrin-2 \| PaTrin 2 \| 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine \| 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine \| CHEMBL339133 \| 6-((4-Bromo-2-thienyl)methoxyl)purin-2-amine \| 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine \| S792
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lomequartrib is an inhibitor of O6 methylguanin-DNA methyltransferase (MGMT) with an IC50 value of 0.009 μM in cell-free extracts from HeLa S3 cells.Potent O 6 -methylguanine-DNA methyltransferase (MGMT) inhibitor (IC 50 = 9 nM). Inhibits recombinant huma
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM. A monosaccharide-linked inhibitor of MGMT.

Associated Targets(Human)

MGMT Tchem Methylated-DNA--protein-cysteine methyltransferase 2 Activities

Discover Target: MGMT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

6-O-methylguanine-DNA methyltransferase 451 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Histone deacetylase 6 222 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Replicase polyprotein 1ab 378 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 38078 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
INCHI	InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChi Key	JUJPKFNFCWJBCX-UHFFFAOYSA-N
Canonical SMILES	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
Isomeric SMILES	C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
WGK Germany	3
RTECS	UO7420000
PubChem CID	3025944
Molecular Weight	326.17

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	UO7420000

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