Lomeguatrib - 98%, high purity , CAS No.192441-08-0

  • ≥98%
Item Number
L125047
Grouped product items
SKUSizeAvailabilityPrice Qty
L125047-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$86.90
L125047-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$249.90

Potent MGMT inhibitor

Basic Description

SynonymsNSC787251 | NSC-787251 | 6-(4-Bromothenyloxy)-7H-purin-2-amine | 6-((4-bromothiophen-2-yl)methoxy)-9H-purin-2-amine | Lomeguatrib [INN] | S79265T71M | SMR004701339 | 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine | HY-13668 | Lomeguatrib, >=98% (HPLC) |
Specifications & Purity≥98%
Biochemical and Physiological MechanismsLomequartrib is an inhibitor of O6 methylguanin-DNA methyltransferase (MGMT) with an IC50 value of 0.009 μM in cell-free extracts from HeLa S3 cells.Potent O 6 -methylguanine-DNA methyltransferase (MGMT) inhibitor (IC 50 = 9 nM). Inhibits recombinant huma
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
A monosaccharide-linked inhibitor of MGMT.

Associated Targets(Human)

MGMT Tchem Methylated-DNA--protein-cysteine methyltransferase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MGMT Tchem 6-O-methylguanine-DNA methyltransferase (451 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
INCHI InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChi Key JUJPKFNFCWJBCX-UHFFFAOYSA-N
Canonical SMILES C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
Isomeric SMILES C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
WGK Germany 3
RTECS UO7420000
PubChem CID 3025944
Molecular Weight 326.17

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mM).

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS UO7420000

Related Documents

Solution Calculators