Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L157774-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $68.90 | |
L157774-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $310.90 | |
L157774-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,117.90 |
Ca 2+ channel blocker
Synonyms | Lomerizine hydrochloride|101477-54-7|Lomerizine dihydrochloride|Lomerizine HCl|LOMERIZINE 2HCL|KB-2796|Terranas|1-(bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride|1-[BIS(4-FLUOROPHENYL)METHYL]-4-(2,3,4-TRIMETHOXYBENZYL)PIPE |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Ca 2+ channel blocker. Inhibits voltage-activated inward calcium currents. Shows vasodilatory and neuroprotective effects against ischemic injury in vivo . Orally active. |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride |
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INCHI | InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H |
InChi Key | LOGVKVSFYBBUAJ-UHFFFAOYSA-N |
Canonical SMILES | COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl |
Isomeric SMILES | COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl |
WGK Germany | 3 |
RTECS | TK9189000 |
PubChem CID | 122125 |
Molecular Weight | 541.46 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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I2201624 | Certificate of Analysis | Jun 15, 2022 | L157774 |
I2201761 | Certificate of Analysis | Jun 15, 2022 | L157774 |
I2201762 | Certificate of Analysis | Jun 15, 2022 | L157774 |
Solubility | ≥ 24.1mg/mL in DMSO with gentle warming |
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Sensitivity | Hygroscopic,Heat Sensitive |
Melt Point(°C) | 180 °C(dec.) |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | TK9189000 |
Merck Index | 5563 |