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Lomerizine Dihydrochloride - ＞98%, high purity , CAS No.101477-54-7

≥98%

CAS#: 101477-54-7
Formula: C₂₇H₃₀F₂N₂O₃·2HCl
Molecular Weight: 541.46
MDL number: MFCD01703867
PubChem CID: 122125

Item Number

L157774

Grouped product items
SKU	Size	Availability	Price
L157774-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
L157774-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$310.90
L157774-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,117.90

Ca 2+ channel blocker

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Calcium Channel Membrane Transporter/Ion Channel Neuronal Signaling Piperazines Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	101477-54-7, 101477-55-8(free base) \| Tox21_112172 \| Lomerizine Dihydrochloride, 98% \| Terranas (TN) \| CS-0012057 \| DTXCID9026427 \| s1082 \| BCP12061 \| LOMERIZINE 2HCL \| NCGC00164543-02 \| FT-0627971 \| D02633 \| NCGC00164543-01 \| Q27258118 \| 1-(2,3,4-Trimeth
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Ca 2+ channel blocker. Inhibits voltage-activated inward calcium currents. Shows vasodilatory and neuroprotective effects against ischemic injury in vivo . Orally active.
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Names and Identifiers

IUPAC Name	1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
INCHI	InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H
InChi Key	LOGVKVSFYBBUAJ-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl
Isomeric SMILES	COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl
WGK Germany	3
RTECS	TK9189000
PubChem CID	122125
Molecular Weight	541.46

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
I2201624	Certificate of Analysis	Jun 15, 2022	L157774
I2201761	Certificate of Analysis	Jun 15, 2022	L157774
I2201762	Certificate of Analysis	Jun 15, 2022	L157774

Solubility

≥ 24.1mg/mL in DMSO with gentle warming

Sensitivity

Hygroscopic,Heat Sensitive

Melt Point(°C)

180 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RTECS	TK9189000
Merck Index	5563

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Lomerizine Dihydrochloride - ＞98%, high purity , CAS No.101477-54-7

Basic Description

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

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