Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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L123247-50mg | 50mg | In stock | $33.90 | |
L123247-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $112.90 | |
L123247-250mg | 250mg | In stock | $127.90 | |
L123247-1g | 1g | In stock | $457.90 |
DNA alkylating agent
Synonyms | 3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea | NCGC00167466-01 | Prava | SCHEMBL3995 | C07079 | LOMUSTINE [HSDB] | N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea | EN300-118685 | FT-0627972 | AKOS005766022 | Belustine | HSDB 6519 | Lomustina (INN-Spanish) |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | DNA alkylating and anticancer agent. Induces hepatotoxicity. Cell and blood-brain barrier permeable. Orally active. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | DNA inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 2.8 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea |
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INCHI | InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) |
InChi Key | GQYIWUVLTXOXAJ-UHFFFAOYSA-N |
Canonical SMILES | C1CCC(CC1)NC(=O)N(CCCl)N=O |
Isomeric SMILES | C1CCC(CC1)NC(=O)N(CCCl)N=O |
WGK Germany | 3 |
RTECS | YS4900000 |
PubChem CID | 3950 |
Molecular Weight | 233.7 |
Enter Lot Number to search for COA:
Sensitivity | Heat Sensitive |
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Melt Point(°C) | 89.0-93.0°C |
Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H350:May cause cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | YS4900000 |
Merck Index | 5564 |
1. Maryam H. Alaayedi, Nidhal K. Maraie. (2023) Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment. SAUDI PHARMACEUTICAL JOURNAL, 31 (101692). [PMID:37457367] [10.1016/j.jsps.2023.06.025] |
1. Maryam H. Alaayedi, Nidhal K. Maraie. (2023) Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment. SAUDI PHARMACEUTICAL JOURNAL, 31 (101692). [PMID:37457367] [10.1016/j.jsps.2023.06.025] |