Grouped product items

SKU

Size

Availability

Price

Qty

L123247-50mg

50mg

In stock

$33.90

L123247-200mg

200mg

Available within 8-12 weeks(?)

$112.90

L123247-250mg

250mg

In stock

$127.90

L123247-1g

In stock

$457.90

Basic Description

Synonyms	3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea \| NCGC00167466-01 \| Prava \| SCHEMBL3995 \| C07079 \| LOMUSTINE [HSDB] \| N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea \| EN300-118685 \| FT-0627972 \| AKOS005766022 \| Belustine \| HSDB 6519 \| Lomustina (INN-Spanish)
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	DNA alkylating and anticancer agent. Induces hepatotoxicity. Cell and blood-brain barrier permeable. Orally active.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	DNA inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Properties

ALogP	2.8

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Pneumocystis carinii (749 Activities)

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Leishmania infantum (5912 Activities)

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Trypanosoma brucei (78846 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Entamoeba histolytica (2676 Activities)

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Cryptosporidium parvum (1150 Activities)

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Plasmodium falciparum (966862 Activities)

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Leishmania amazonensis (3813 Activities)

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Leishmania donovani (89745 Activities)

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Leishmania major (2877 Activities)

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Leishmania mexicana (936 Activities)

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Trypanosoma cruzi (99888 Activities)

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Trichomonas vaginalis (2376 Activities)

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Toxoplasma gondii (4585 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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13762 (31 Activities)

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L1210 (27553 Activities)

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P388 (20296 Activities)

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P388/ADR (1216 Activities)

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Sarcoma-180 (387 Activities)

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W256 (236 Activities)

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Ehrlich (1318 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Liver microsome (341 Activities)

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Glra2 Glycine receptor (1745 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
INCHI	InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChi Key	GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Canonical SMILES	C1CCC(CC1)NC(=O)N(CCCl)N=O
Isomeric SMILES	C1CCC(CC1)NC(=O)N(CCCl)N=O
WGK Germany	3
RTECS	YS4900000
PubChem CID	3950
Molecular Weight	233.7

Database links

DrugBank Ligand	DB01206
PubChem CID	3950
CAS Registry No.	13010-47-4
ChEMBL Ligand	CHEMBL514
Wikipedia	Lomustine
PEP	lomustine
DrugCentral Ligand	1596

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
A1921047	Certificate of Analysis	Nov 15, 2022	L123247
L1804145	Certificate of Analysis	Sep 22, 2022	L123247
G1425014	Certificate of Analysis	May 06, 2022	L123247

Chemical and Physical Properties

Sensitivity	Heat Sensitive
Melt Point(°C)	89.0-93.0°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H350:May cause cancer
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
WGK Germany	3
RTECS	YS4900000
Merck Index	5564

Citations of This Product

1. Maryam H. Alaayedi, Nidhal K. Maraie. (2023) Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment. SAUDI PHARMACEUTICAL JOURNAL, 31 (101692). [PMID:37457367]

References

1. Maryam H. Alaayedi, Nidhal K. Maraie. (2023) Lomustine’s nanoemulsion as nose-to-brain drug delivery system for CNS tumor treatment. SAUDI PHARMACEUTICAL JOURNAL, 31 (101692). [PMID:37457367]

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Lomustine - 98%, high purity , DNA inhibitor, CAS No.13010-47-4, DNA inhibitor

Basic Description

Product Properties

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator