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Lonapalene - 99%, high purity , CAS No.91431-42-4
Basic Description Synonyms LONAPALENE | 91431-42-4 | RS-43179 | RS4317 | Lonapalene (USAN) | Lonapalene [USAN] | (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate | WIF31Q54NJ | 6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate | CHEMBL36648 | Lonapalenum | Lonapaleno | 6-chloro-2,3-dimethoxy Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Lonapalene (RS4317) is a topically effective 5-lipoxygenase ( 5-LO ) inhibitor. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Lonapalene (RS4317) is a topically effective 5-lipoxygenase ( 5-LO ) inhibitor.
In Vitro
Lonapalene (RS4317) may be useful in the treatment of psoriasis, and that leukotriene B4 is a relevant mediator of the pathology of this disease. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:5-LO
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate INCHI InChI=1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3 InChi Key IFWMVQUGSGWCRP-UHFFFAOYSA-N Canonical SMILES CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC Isomeric SMILES CC(=O)OC1=C(C(=C(C2=C1C=CC(=C2)Cl)OC(=O)C)OC)OC Alternate CAS 91431-42-4 PubChem CID 56237 MeSH Entry Terms 6-chloro-2,3-dimethoxynaphthalene-1,4-diol diacetate;lonapalene;RS 43179;RS-43179 Molecular Weight 338.74
Chemical and Physical Properties Solubility DMSO : 100 mg/mL (295.21 mM; Need ultrasonic)
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