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Lonidamine - ≥99%, high purity , CAS No.50264-69-2, Inhibitor of mitochondrial pyruvate carrier 1 like;Inhibitor of mitochondrial pyruvate carrier 2
Basic Description Synonyms lonidamine|50264-69-2|1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid|Diclondazolic acid|Doridamina|DICA|Lonidamina|Lonidaminum|1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid|Lonidamin|AF 1890|C15H10Cl2N2O2|1-(2,4-Dichlorbenzyl)-indazol Specifications & Purity ≥99% Storage Temp Store at -20°C,Argon charged Shipped In Dry ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of mitochondrial pyruvate carrier 1 like;Inhibitor of mitochondrial pyruvate carrier 2 Product Description Product Describtion:
Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro.
Names and Identifiers IUPAC Name 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid INCHI InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21) InChi Key WDRYRZXSPDWGEB-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O Isomeric SMILES C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O WGK Germany 3 Alternate CAS 50264-69-2 PubChem CID 39562 NSC Number 741419 MeSH Entry Terms 1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid;AF 1890;diclondazolic acid;lonidamine Molecular Weight 321.16
Chemical and Physical Properties Solubility Soluble in ethanol (5 mM), DMSO (100 mM), CHCl3/MeOH 1/1 (9.80-10.20 mg/ml), water (<1 mg/ml at 25° C), DMSO (64 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C). Sensitivity Air Sensitive Melt Point(°C) 210 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H351: Suspected of causing cancer
H302: Harmful if swallowed
H360: May damage fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
WGK Germany 3
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