Lonidamine - ≥99%, high purity , CAS No.50264-69-2, Inhibitor of mitochondrial pyruvate carrier 1 like;Inhibitor of mitochondrial pyruvate carrier 2

Item Number

L129342

• Synonyms: AF-1890;Diclondazolic Acid;DICA | AM20060642 | CCG-204803 | A929099 | KN-228 | Lopac-L-4900 | Diclondazolic acid | HMS3412P05 | L 4900 | NCGC00015609-09 | Pharmakon1600-01503225 | WDRYRZXSPDWGEB-UHFFFAOYSA-N | 1-(2,4-dichlorobenzyl)indazole-3-carboxylic a
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Inhibits the energy metabolism of neoplastic cells by interfering with hexokinase and disrupting uncoupler-stimulated mitochondrial electron transport; damages cell and mitochondrial membranes.
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of mitochondrial pyruvate carrier 1 like;Inhibitor of mitochondrial pyruvate carrier 2
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Describtion:

Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro.
It elicits cell apoptosis and blocks CFTR Cl- channel.