Lopinavir - 95%, high purity , CAS No.192725-17-0

Item Number

L299096

• Synonyms: ABT-378 | (2S)-N-[(2R,4S,5S)-5-[[2-(2,6-DIMETHYLPHENOXY)ACETYL]AMINO]-4-HYDROXY-1,6-DIPHENYL-HEXAN-2-YL]-3-METHYL-2-(2-OXO-1,3-DIAZINAN-1-YL)BUTANAMIDE | (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-DIMETHYLPHENOXY)ACETYL)AMINO)-3-HYDROXY-5-PHENYL-1-(PHENYLMETHYL)P
• Specifications & Purity: Moligand™, ≥95%
• Biochemical and Physiological Mechanisms: Highly potent and selective HIV-1 protease inhibitor (IC50= 6.5 nM, HIV cultured in peripheral blood mononuclear cells; Ki= 1.3 pM). Displays >105-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Lopinavir is an antiviral HIV Protease Inhibitor. Lopinavir has insufficient bioavailability alone, so it is used in therapy in combination with Ritonavir, a HIV protease inhibitor, which inhibits cytochrome P450-3A4 (CYP3A4), a liver enzyme that normally metabolizes protease inhibitors. Lopinavir also has an ability to inhibit ZMPSTE24 (zinc metallopeptidase STE24).
Lopinavir has been used as a ZMPSTE24 and human immunodeficiency virus protease inhibitor.