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Loreclezole hydrochloride , CAS No.117857-45-1
a subtype-selective GABAAreceptor agonist
Basic Description Synonyms HY-105272 | BS-14505 | Loreclezole [USAN:INN:BAN] | 6DJ32STZ5W | DTXSID6048252 | LORECLEZOLE [USAN] | R 72063 | Loreclezol [INN-Spanish] | Loreclezole | GTPL5466 | LORECLEZOLE [INN] | (Z)-1-(.beta.,2,4-Trichlorostyryl)-1H-1,2,4-triazole | 1-[(Z)-2-chloro- Specifications & Purity Moligand™ Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Product Description Loreclezole hydrochloride is a subtype-selective GABA|A|receptor agonist. Positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA|A|receptor sensitization. Inhibits homomeric ρ1 GABA|C|receptors.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-[(Z)-2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1,2,4-triazole INCHI InChI=1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4- InChi Key XGLHZTBDUXXHOM-WMZJFQQLSA-N Canonical SMILES C1=CC(=C(C=C1Cl)Cl)C(=CN2C=NC=N2)Cl Isomeric SMILES C1=CC(=C(C=C1Cl)Cl)/C(=C/N2C=NC=N2)/Cl RTECS XZ4382000 PubChem CID 3034012 Molecular Weight 311
Chemical and Physical Properties Solubility Soluble in ethanol (5 mM with gentle warming), and DMSO (5 mM with gentle warming). Refractive Index n20D1.65 (Predicted) Boil Point(°C) 442.7° C at 760 mmHg (Predicted)
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