Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P167337-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $70.90 | |
P167337-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $105.90 | |
P167337-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $177.90 | |
P167337-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $284.90 | |
P167337-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $497.90 | |
P167337-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,120.90 | |
P167337-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $4,033.90 |
Synonyms | Lorlatinib|1454846-35-5|PF-06463922|Loratinib|Lorbrena|Lorviqua|lorlatinibum|PF 06463922|UNII-OSP71S83EU|PF06463922|OSP71S83EU|PFE-PKIS 10|PF06463922(Lorlatinib)|CHEMBL3286830|CHEBI:143117|(10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-1 |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | EML4-ALK inhibitor |
ALogP | 1.5 |
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IUPAC Name | (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile |
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INCHI | InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1 |
InChi Key | IIXWYSCJSQVBQM-LLVKDONJSA-N |
Canonical SMILES | CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C |
Isomeric SMILES | C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C |
PubChem CID | 71731823 |
Molecular Weight | 406.41 |
PubChem CID | 71731823 |
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ChEMBL Ligand | CHEMBL3286830 |
CAS Registry No. | 1454846-35-5 |
RCSB PDB Ligand | 53P, 5P8, QB4 |
DrugCentral Ligand | 5302 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F23251452 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251460 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251490 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251513 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251520 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251528 | Certificate of Analysis | May 20, 2023 | P167337 |
F23251540 | Certificate of Analysis | May 20, 2023 | P167337 |
Solubility | insoluble in H2O; ≥20.3 mg/mL in DMSO; ≥5.85 mg/mL in EtOH |
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Sensitivity | Moisture sensitive |
Pictogram(s) | GHS08, GHS09 |
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Signal | Warning |
Hazard Statements | H341:Suspected of causing genetic defects H373:Causes damage to organs through prolonged or repeated exposure H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
1. Facchinetti F, Tiseo M, Di Maio M, Graziano P, Bria E, Rossi G, Novello S. (2016) Tackling ALK in non-small cell lung cancer: the role of novel inhibitors.. Transl Lung Cancer Res, 5 (3): (301-21). [PMID:27413712] |
2. Johnson TW, Richardson PF, Bailey S, Brooun A, Burke BJ, Collins MR, Cui JJ, Deal JG, Deng YL, Dinh D et al.. (2014) Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.. J Med Chem, 57 (11): (4720-44). [PMID:24819116] |
3. Shaw AT, Friboulet L, Leshchiner I, Gainor JF, Bergqvist S, Brooun A, Burke BJ, Deng YL, Liu W, Dardaei L et al.. (2016) Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.. N Engl J Med, 374 (1): (54-61). [PMID:26698910] |
4. Shipman L. (2016) Resistance: Crizotinib makes a comeback.. Nat Rev Cancer, 16 (2): (69). [PMID:26797648] |
5. Zou HY, Li Q, Engstrom LD, West M, Appleman V, Wong KA, McTigue M, Deng YL, Liu W, Brooun A et al.. (2015) PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.. Proc Natl Acad Sci USA, 112 (11): (3493-8). [PMID:25733882] |
6. Saha D, Kharbanda A, Yan W, Lakkaniga NR, Frett B, Li HY. (2020) The Exploration of Chirality for Improved Druggability within the Human Kinome.. J Med Chem, 63 (2): (441-469). [PMID:31550151] |