Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has
Shipped In
Normal
Action Type
ANTAGONIST
Mechanism of action
Type-1 angiotensin II receptor antagonist
Note
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Product Description
Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.
Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension. A specific antagonist of the AT1 receptor with significant downstream effects.
Associated Targets(Human)
AGTR1TclinType-1 angiotensin II receptor (1 Activities)
1.Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2024) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 126 (17):(105825). [PMID:17580304][10.1016/j.jfca.2023.105825]
2.Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2023) 8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 741 (109617). [PMID:37121295][10.1016/j.abb.2023.109617]
4.Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao. (2022) Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method. CHROMATOGRAPHIA, 85 (3):(221-231). [PMID:][10.1007/s10337-021-04126-8]
5.Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2021) Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats. JOURNAL OF ETHNOPHARMACOLOGY, 281 (114521). [PMID:34390794][10.1016/j.jep.2021.114521]
6.Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Bin Wang, Xiaoyuan Ma, Chifang Peng, Zhouping Wang, Wenshui Xia. (2021) A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties. CARBOHYDRATE RESEARCH, 503 (108315). [PMID:33865180][10.1016/j.carres.2021.108315]
References
1.Hu B et al.. (2018) Angiotensin II facilitates GABAergic neurotransmission at postsynaptic sites in rat amygdala neurons.. Neuropharmacology, 133 (334-344). [PMID:29447844]
2.Oliveira PA et al.. (2017) Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia.. Sci Rep, 7 (1857). [PMID:28500295]
3.Ageeva LV et al.. (2018) Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro.. Data Brief, 16 (327-333). [PMID:29234689]
4.Sysoeva VY et al.. (2017) Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor.. Stem Cell Res, 25 (115-122). [PMID:29127873]
5.Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2024) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 126 (17):(105825). [PMID:17580304][10.1016/j.jfca.2023.105825]
6.Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2023) 8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 741 (109617). [PMID:37121295][10.1016/j.abb.2023.109617]
8.Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao. (2022) Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method. CHROMATOGRAPHIA, 85 (3):(221-231). [PMID:][10.1007/s10337-021-04126-8]
9.Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2021) Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats. JOURNAL OF ETHNOPHARMACOLOGY, 281 (114521). [PMID:34390794][10.1016/j.jep.2021.114521]
10.Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Bin Wang, Xiaoyuan Ma, Chifang Peng, Zhouping Wang, Wenshui Xia. (2021) A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties. CARBOHYDRATE RESEARCH, 503 (108315). [PMID:33865180][10.1016/j.carres.2021.108315]
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