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Lovastatin - 98%, high purity , HMG-CoA reductase inhibitor, CAS No.75330-75-5, HMG-CoA reductase inhibitor

Moligand™
≥98%

CAS#: 75330-75-5
Formula: C₂₄H₃₆O₅
Molecular Weight: 404.54
MDL number: MFCD00072164
PubChem CID: 53232

Item Number

L107709

Grouped product items
SKU	Size	Availability	Price
L107709-1g	1g	In stock	$14.90
L107709-5g	5g	In stock	$57.90
L107709-25g	25g	In stock	$219.90
L107709-100g	100g	In stock	$790.90

Potent HMG-CoA reductase inhibitor

View related series

hydroxymethylglutaryl-CoA reductase Inhibitor Pregnane X receptor Agonist

Basic Description

Synonyms	lovastatin\|75330-75-5\|mevinolin\|Mevacor\|Altoprev\|Mevlor\|Sivlor\|Lovalord\|Nergadan\|Altocor\|Artein\|MK-803\|Monacolin K\|Cholestra\|Closterol\|Hipovastin\|Lestatin\|Lipofren\|Lovasterol\|Lovastin\|Tecnolip\|Teroltrat\|6alpha-Methylcompactin\|Belvas\|Colevix\|Hipolip\|Lipdip
Specifications & Purity	98%
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Dry ice
Grade	Moligand™
Action Type	AGONIST, INHIBITOR
Mechanism of action	HMG-CoA reductase inhibitor

Product Properties

ALogP	4.3

Associated Targets

HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 23 Activities

Discover Target: HMGCR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities

Discover Target: NR1I2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
INCHI	InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChi Key	PCZOHLXUXFIOCF-BXMDZJJMSA-N
Canonical SMILES	CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
Isomeric SMILES	CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
WGK Germany	3
RTECS	EK7907000
PubChem CID	53232
Molecular Weight	404.54

Database links

CAS Registry No.	75330-75-5
PubChem CID	53232
DrugBank Ligand	DB00227
ChEBI	CHEBI:40303
Wikipedia	Lovastatin
BindingDB Ligand	34168
ChEMBL Ligand	CHEMBL503
NURSA Ligand	10.1621/9W6AOGTCZU
RCSB PDB Ligand	803
PEP	lovastatin
DrugCentral Ligand	1612

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
A2423043	Certificate of Analysis	Mar 15, 2022	L107709
D2303495	Certificate of Analysis	Mar 15, 2022	L107709
F2207110	Certificate of Analysis	Mar 15, 2022	L107709
F2207111	Certificate of Analysis	Mar 15, 2022	L107709
F2207112	Certificate of Analysis	Mar 15, 2022	L107709
F2207113	Certificate of Analysis	Mar 15, 2022	L107709
L2307139	Certificate of Analysis	Mar 15, 2022	L107709

Chemical and Physical Properties

Solubility	Insoluble in water; Degree of Solubility in water: 0.4 mg/l 25 °C; Soluble in Ethanol,Methanol
Sensitivity	light sensitive
Specific Rotation[α]	320 ° (C=0.5, CH3CN)
Melt Point(°C)	175°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H351:Suspected of causing cancer H302:Harmful if swallowed H317:May cause an allergic skin reaction H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	EK7907000
Merck Index	5586

References

1. Choi HW, Shin PG, Lee JH, Choi WS, Kang MJ, Kong WS, Oh MJ, Seo YB, Kim GD. (2018) Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.. Int J Mol Med, 41 (2): (1103-1109). [PMID:29207042]
2. Peng Y et al.. (2017) Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.. J Cancer, 8 (9): (1655-1664). [PMID:28775785]
3. Zheng C et al.. (2021) Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins.. Front Oncol, 11 (656687). [PMID:34150623]
4. Restivo G et al.. (2017) low neurotrophin receptor CD271 regulates phenotype switching in melanoma.. Nat Commun, 8 (1988). [PMID:29215016]
5. Dorsch M et al.. (2021) Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.. Cell Rep, 37 (8): (110056). [PMID:34818551]
6. Farfan-Morales CN et al.. (2021) The antiviral effect of metformin on zika and dengue virus infection.. Sci Rep, 11 (8743). [PMID:33888740]
7. Canela A et al.. (2019) Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.. Mol Cell, 75 (2): (252-266.e8). [PMID:31202577]

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