Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L107709-1g | 1g | In stock | $14.90 | |
L107709-5g | 5g | In stock | $57.90 | |
L107709-25g | 25g | In stock | $219.90 | |
L107709-100g | 100g | In stock | $790.90 |
Potent HMG-CoA reductase inhibitor
Synonyms | 1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactone | Liposcler | Lovalip | LOVASTATIN (USP-RS) | LOVASTATIN [MART.] | Hipolip | (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, competitive HMG-CoA reductase inhibitor (K i = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo . |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | HMG-CoA reductase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 4.3 |
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IUPAC Name | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
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INCHI | InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 |
InChi Key | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
Canonical SMILES | CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C |
Isomeric SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
WGK Germany | 3 |
RTECS | EK7907000 |
PubChem CID | 53232 |
Molecular Weight | 404.54 |
CAS Registry No. | 75330-75-5 |
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PubChem CID | 53232 |
DrugBank Ligand | DB00227 |
ChEBI | CHEBI:40303 |
Wikipedia | Lovastatin |
BindingDB Ligand | 34168 |
ChEMBL Ligand | CHEMBL503 |
NURSA Ligand | 10.1621/9W6AOGTCZU |
RCSB PDB Ligand | 803 |
PEP | lovastatin |
DrugCentral Ligand | 1612 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2423043 | Certificate of Analysis | Mar 15, 2022 | L107709 |
D2303495 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207110 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207111 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207112 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207113 | Certificate of Analysis | Mar 15, 2022 | L107709 |
L2307139 | Certificate of Analysis | Mar 15, 2022 | L107709 |
Solubility | Insoluble in water; Degree of Solubility in water: 0.4 mg/l 25 °C; Soluble in Ethanol,Methanol |
---|---|
Sensitivity | light sensitive |
Specific Rotation[α] | 320 ° (C=0.5, CH3CN) |
Melt Point(°C) | 175°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H317:May cause an allergic skin reaction H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | EK7907000 |
Merck Index | 5586 |
1. Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie. (2023) Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia. PHYTOMEDICINE, (155313). [PMID:38520833] |
2. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 255 (115391). [PMID:37099836] |
3. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang. (2023) Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways. ACS Chemical Neuroscience, 14 (7): (1331–1341). [PMID:36917811] |
4. Bo Wei, Yuanfang Li, Meiying Ao, Wenxiang Shao, Kun Wang, Tong Rong, Yun Zhou, Yong Chen. (2022) Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoE−/− C57BL/6 Mice. Pharmaceutics, 14 (11): (2534). [PMID:36432725] |
5. Qing Sun, Li Li, Quan Zhou. (2022) Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats. Drug Design Development and Therapy, [PMID:35607596] |
6. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng. (2022) Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer, 21 (1): (1-17). [PMID:35303882] |
7. Ping-Ting Xiao, Yu-Jia Kuang, Shi-Yu Liu, Zhi-Shen Xie, Jin-Hua Hao, E-Hu Liu. (2022) The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata ‘Chachi’. JOURNAL OF FOOD AND DRUG ANALYSIS, 30 (1): ( 77–87). [PMID:35647727] |
8. Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang. (2022) Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (10): (3172–3180). [PMID:35227062] |
9. Zhishen Xie, Er-wen Li, Gai Gao, Yueyue Du, Mengyao Wang, Hui Wang, Pan Wang, Yonghui Qiao, Yunfang Su, Jiangyan Xu, Xiaowei Zhang, Zhenqiang Zhang. (2022) Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia. JOURNAL OF ETHNOPHARMACOLOGY, 290 (115101). [PMID:35151834] |
10. Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. (2022) A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of Materials Chemistry B, 10 (4): (607-624). [PMID:34994373] |
11. Zhang M,Wang Z,Hao S,Hao L,Zhang X,Yu P,Sun H. (2020) Synthesis of natural 3'-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome.. Eur J Med Chem, 205 (112649-112649). [PMID:32791402] |
1. Choi HW, Shin PG, Lee JH, Choi WS, Kang MJ, Kong WS, Oh MJ, Seo YB, Kim GD. (2018) Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.. Int J Mol Med, 41 (2): (1103-1109). [PMID:29207042] |
2. Peng Y et al.. (2017) Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.. J Cancer, 8 (9): (1655-1664). [PMID:28775785] |
3. Zheng C et al.. (2021) Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins.. Front Oncol, 11 (656687). [PMID:34150623] |
4. Restivo G et al.. (2017) low neurotrophin receptor CD271 regulates phenotype switching in melanoma.. Nat Commun, 8 (1988). [PMID:29215016] |
5. Dorsch M et al.. (2021) Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.. Cell Rep, 37 (8): (110056). [PMID:34818551] |
6. Farfan-Morales CN et al.. (2021) The antiviral effect of metformin on zika and dengue virus infection.. Sci Rep, 11 (8743). [PMID:33888740] |
7. Canela A et al.. (2019) Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.. Mol Cell, 75 (2): (252-266.e8). [PMID:31202577] |
8. Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie. (2023) Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia. PHYTOMEDICINE, (155313). [PMID:38520833] |
9. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 255 (115391). [PMID:37099836] |
10. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang. (2023) Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways. ACS Chemical Neuroscience, 14 (7): (1331–1341). [PMID:36917811] |
11. Bo Wei, Yuanfang Li, Meiying Ao, Wenxiang Shao, Kun Wang, Tong Rong, Yun Zhou, Yong Chen. (2022) Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoE−/− C57BL/6 Mice. Pharmaceutics, 14 (11): (2534). [PMID:36432725] |
12. Qing Sun, Li Li, Quan Zhou. (2022) Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats. Drug Design Development and Therapy, [PMID:35607596] |
13. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng. (2022) Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer, 21 (1): (1-17). [PMID:35303882] |
14. Ping-Ting Xiao, Yu-Jia Kuang, Shi-Yu Liu, Zhi-Shen Xie, Jin-Hua Hao, E-Hu Liu. (2022) The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata ‘Chachi’. JOURNAL OF FOOD AND DRUG ANALYSIS, 30 (1): ( 77–87). [PMID:35647727] |
15. Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang. (2022) Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (10): (3172–3180). [PMID:35227062] |
16. Zhishen Xie, Er-wen Li, Gai Gao, Yueyue Du, Mengyao Wang, Hui Wang, Pan Wang, Yonghui Qiao, Yunfang Su, Jiangyan Xu, Xiaowei Zhang, Zhenqiang Zhang. (2022) Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia. JOURNAL OF ETHNOPHARMACOLOGY, 290 (115101). [PMID:35151834] |
17. Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. (2022) A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of Materials Chemistry B, 10 (4): (607-624). [PMID:34994373] |
18. Zhang M,Wang Z,Hao S,Hao L,Zhang X,Yu P,Sun H. (2020) Synthesis of natural 3'-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome.. Eur J Med Chem, 205 (112649-112649). [PMID:32791402] |