Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L107709-1g | 1g | In stock | $14.90 | |
L107709-5g | 5g | In stock | $57.90 | |
L107709-25g | 25g | In stock | $219.90 | |
L107709-100g | 100g | In stock | $790.90 |
Potent HMG-CoA reductase inhibitor
Synonyms | 1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactone | Liposcler | Lovalip | LOVASTATIN (USP-RS) | LOVASTATIN [MART.] | Hipolip | (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent, competitive HMG-CoA reductase inhibitor (K i = 0.6 nM). Blood-brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo . |
Storage Temp | Protected from light,Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, INHIBITOR |
Mechanism of action | HMG-CoA reductase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 4.3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate |
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INCHI | InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 |
InChi Key | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
Canonical SMILES | CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C |
Isomeric SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
WGK Germany | 3 |
RTECS | EK7907000 |
PubChem CID | 53232 |
Molecular Weight | 404.54 |
CAS Registry No. | 75330-75-5 |
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PubChem CID | 53232 |
DrugBank Ligand | DB00227 |
ChEBI | CHEBI:40303 |
Wikipedia | Lovastatin |
BindingDB Ligand | 34168 |
ChEMBL Ligand | CHEMBL503 |
NURSA Ligand | 10.1621/9W6AOGTCZU |
RCSB PDB Ligand | 803 |
PEP | lovastatin |
DrugCentral Ligand | 1612 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
A2423043 | Certificate of Analysis | Mar 15, 2022 | L107709 |
D2303495 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207110 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207111 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207112 | Certificate of Analysis | Mar 15, 2022 | L107709 |
F2207113 | Certificate of Analysis | Mar 15, 2022 | L107709 |
K2415060 | Certificate of Analysis | Mar 15, 2022 | L107709 |
L2307139 | Certificate of Analysis | Mar 15, 2022 | L107709 |
L2403085 | Certificate of Analysis | Mar 15, 2022 | L107709 |
L2403086 | Certificate of Analysis | Mar 15, 2022 | L107709 |
Solubility | Insoluble in water; Degree of Solubility in water: 0.4 mg/l 25 °C; Soluble in Ethanol,Methanol |
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Sensitivity | light sensitive |
Specific Rotation[α] | 320 ° (C=0.5, CH3CN) |
Melt Point(°C) | 175°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H317:May cause an allergic skin reaction H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | EK7907000 |
Merck Index | 5586 |
1. Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie. (2023) Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia. PHYTOMEDICINE, (155313). [PMID:38520833] [10.1016/j.phymed.2023.155313] |
2. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun. (2023) Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 255 (115391). [PMID:37099836] [10.1016/j.ejmech.2023.115391] |
3. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang. (2023) Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways. ACS Chemical Neuroscience, 14 (7): (1331–1341). [PMID:36917811] [10.1021/acschemneuro.3c00104] |
4. Bo Wei, Yuanfang Li, Meiying Ao, Wenxiang Shao, Kun Wang, Tong Rong, Yun Zhou, Yong Chen. (2022) Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoE−/− C57BL/6 Mice. Pharmaceutics, 14 (11): (2534). [PMID:36432725] [10.3390/pharmaceutics14112534] |
5. Qing Sun, Li Li, Quan Zhou. (2022) Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats. Drug Design Development and Therapy, [PMID:35607596] [10.2147/DDDT.S364234] |
6. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng. (2022) Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. Molecular Cancer, 21 (1): (1-17). [PMID:35303882] [10.1186/s12943-022-01547-3] |
7. Ping-Ting Xiao, Yu-Jia Kuang, Shi-Yu Liu, Zhi-Shen Xie, Jin-Hua Hao, E-Hu Liu. (2022) The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata ‘Chachi’. JOURNAL OF FOOD AND DRUG ANALYSIS, 30 (1): ( 77–87). [PMID:35647727] [10.38212/2224-6614.3388] |
8. Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang. (2022) Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70 (10): (3172–3180). [PMID:35227062] [10.1021/acs.jafc.1c07733] |
9. Zhishen Xie, Er-wen Li, Gai Gao, Yueyue Du, Mengyao Wang, Hui Wang, Pan Wang, Yonghui Qiao, Yunfang Su, Jiangyan Xu, Xiaowei Zhang, Zhenqiang Zhang. (2022) Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia. JOURNAL OF ETHNOPHARMACOLOGY, 290 (115101). [PMID:35151834] [10.1016/j.jep.2022.115101] |
10. Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. (2022) A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of Materials Chemistry B, 10 (4): (607-624). [PMID:34994373] [10.1039/D1TB01455B] |
11. Hong Zhang, Shaoting Sang, Huimin Xu, Linghua Piao, Xiande Liu. (2021) Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis. Journal of Functional Foods, 86 (104693). [PMID:] [10.1016/j.jff.2021.104693] |
12. Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian. (2021) Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation. NEUROCHEMISTRY INTERNATIONAL, 148 (105078). [PMID:34048842] [10.1016/j.neuint.2021.105078] |
13. Ping-Ting Xiao, Zhi-Shen Xie, Yu-Jia Kuang, Shi-Yu Liu, Chun Zeng, Ping Li, E-Hu Liu. (2021) Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway. Acta Pharmaceutica Sinica B, 11 (3542). [PMID:34900535] [10.1016/j.apsb.2021.03.031] |
14. Na Deng, Ziqian He, Ruixue Guo, Bisheng Zheng, Tong Li, Rui Hai Liu. (2020) Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (42): (11735–11746). [PMID:32985184] [10.1021/acs.jafc.0c04780] |
15. Guihua Yan, Yunchao Feng, Zhebang Gao, Xianhai Zeng, Wenjing Hong, Wenjie Liu, Yong Sun, Xing Tang, Tingzhou Lei, Lu Lin. (2019) Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery. ACS Sustainable Chemistry & Engineering, 7 (24): (19824–19831). [PMID:] [10.1021/acssuschemeng.9b05144] |
16. Kun Wang, Chuan Yu, Yang Liu, Wendiao Zhang, Yanan Sun, Yong Chen. (2018) Enhanced Antiatherosclerotic Efficacy of Statin-Loaded Reconstituted High-Density Lipoprotein via Ganglioside GM1 Modification. ACS Biomaterials Science & Engineering, 4 (3): (952–962). [PMID:33418777] [10.1021/acsbiomaterials.7b00871] |
17. Yu Zhang, Shiguo Chen, Chaoyang Wei, Jianchu Chen, Xingqian Ye. (2017) Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells. Journal of Functional Foods, 29 (217). [PMID:] [10.1016/j.jff.2016.12.030] |
18. Zu-Guo Zheng, Ya-Ping Zhou, Xin Zhang, Pyone Myat Thu, Zhi-Shen Xie, Chong Lu, Tao Pang, Bin Xue, Da-Qian Xu, Yan Chen, Xiao-Wei Chen, Hui-Jun Li, Xiaojun Xu. (2016) Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. BIOCHEMICAL PHARMACOLOGY, 122 (42). [PMID:27816546] [10.1016/j.bcp.2016.10.016] |
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20. Zhang M,Wang Z,Hao S,Hao L,Zhang X,Yu P,Sun H. (2020) Synthesis of natural 3'-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome.. Eur J Med Chem, 205 (112649-112649). [PMID:32791402] [10.1016/j.ejmech.2020.112649] |
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