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LP 99 - ≥98%(HPLC), high purity , CAS No.1808951-93-0, Inhibitor of bromodomain containing 7;Inhibitor of bromodomain containing 9

Item Number
L288566
Grouped product items
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L288566-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$42.90
L288566-5mg
5mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$177.90
L288566-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$296.90
L288566-25mg
25mg
In stock
$642.90
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Selective BRD7 and BRD9 inhibitor

View related series
bromodomain containing 7 Inhibitor bromodomain containing 9 Inhibitor

Basic Description

Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsSelective BRD7 and BRD9 inhibitor (Kdvalues are 99 and 909 nM, respectively). Exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). Inhibits interactions with histones H3.3 and H4 at low micromolar concentrations. Decreases the level
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of bromodomain containing 7;Inhibitor of bromodomain containing 9

Associated Targets(Human)

BRD9 Tchem Bromodomain-containing protein 9 (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BRD7 Tchem Bromodomain-containing protein 7 (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THP-1 (11052 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD7 Tchem Bromodomain-containing protein 7 (146 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD9 Tchem Bromodomain-containing protein 9 (684 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488202529
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202529
IUPAC Name N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide
INCHI InChI=1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1
InChi Key LVDRREOUMKACNJ-BKMJKUGQSA-N
Canonical SMILES CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
Isomeric SMILES CC1=CC(=O)N(C2=C1C=CC(=C2)N3[C@@H]([C@H](CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
PubChem CID 91827372
Molecular Weight 516.05

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
D23181267Certificate of AnalysisMar 13, 2023 L288566
D23181276Certificate of AnalysisMar 13, 2023 L288566
D23181287Certificate of AnalysisMar 13, 2023 L288566
D23181340Certificate of AnalysisMar 13, 2023 L288566
D23181461Certificate of AnalysisMar 13, 2023 L288566
D23181469Certificate of AnalysisMar 13, 2023 L288566

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 51.6, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 51.6, Max Conc. mM: 100

Related Documents

 SDS

 Specification Sheet

References

1. Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, Monteiro OP, Bennett JM, Baronio R, Müller S et al..  (2015)  LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor..  Angew Chem Int Ed Engl,  54  (21): (6217-21).  [PMID:25864491]

Solution Calculators

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