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LP 99 - ≥98%(HPLC), high purity , CAS No.1808951-93-0, Inhibitor of bromodomain containing 7;Inhibitor of bromodomain containing 9

  • Moligand™
  • ≥98%(HPLC)
Item Number
L288566
Grouped product items
SKUSizeAvailabilityPrice Qty
L288566-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$42.90
L288566-5mg
5mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$177.90
L288566-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$296.90
L288566-25mg
25mg
In stock
$642.90
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Selective BRD7 and BRD9 inhibitor

View related series
bromodomain containing 7 Inhibitor bromodomain containing 9 Inhibitor

Basic Description

SynonymsN-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsSelective BRD7 and BRD9 inhibitor (Kdvalues are 99 and 909 nM, respectively). Exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). Inhibits interactions with histones H3.3 and H4 at low micromolar concentrations. Decreases the level
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of bromodomain containing 7;Inhibitor of bromodomain containing 9

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CSNK1D Tchem Casein kinase I isoform delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD9 Tchem Bromodomain-containing protein 9 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRD7 Tchem Bromodomain-containing protein 7 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BRPF1 Tchem Peregrin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488202529
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202529
IUPAC Name N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide
INCHI InChI=1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1
InChi Key LVDRREOUMKACNJ-BKMJKUGQSA-N
Canonical SMILES CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
Isomeric SMILES CC1=CC(=O)N(C2=C1C=CC(=C2)N3[C@@H]([C@H](CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
PubChem CID 91827372
Molecular Weight 516.05

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot NumberCertificate TypeDateItem
D23181267Certificate of AnalysisMar 13, 2023 L288566
D23181276Certificate of AnalysisMar 13, 2023 L288566
D23181287Certificate of AnalysisMar 13, 2023 L288566
D23181340Certificate of AnalysisMar 13, 2023 L288566
D23181461Certificate of AnalysisMar 13, 2023 L288566
D23181469Certificate of AnalysisMar 13, 2023 L288566

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 51.6, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 51.6, Max Conc. mM: 100

Related Documents

 SDS

 Specification Sheet

References

1. Clark PG, Vieira LC, Tallant C, Fedorov O, Singleton DC, Rogers CM, Monteiro OP, Bennett JM, Baronio R, Müller S et al..  (2015)  LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor..  Angew Chem Int Ed Engl,  54  (21): (6217-21).  [PMID:25864491]

Solution Calculators

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