Potent, partially reversible phospholipase A2 (PLA 2 ) inhibitor (IC 50 = 5 µM). Also a novel RARα agonist (EC 50 = 1 μM). Derivative of marine sponge Luffariella sp. Displays anti-inflammatory activity and active in vivo .
Storage Temp
Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear).
Associated Targets(Human)
PLA2G2ATchemPhospholipase A2 group IIA (1079 Activities)
