| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab177879-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
| Ab177879-1mg | 1mg | In stock | $259.90 | |
| Ab177879-5mg | 5mg | In stock | $749.90 | |
| Ab177879-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,189.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Lumiliximab (anti-FceR2) - Primary antibody, specific to FCER2, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | BLAST-2 | C-type lectin domain family 4 member J | Fc-epsilon-RII | Immunoglobulin E-binding factor | Lymphocyte IgE receptor |
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Host species | Human |
| Specificity | FCER2 |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of Immunoglobulin epsilon Fc receptor antagonist |
| Product Description | Lumiliximab (anti-FceR2) is an anti-CD23 monoclonal antibody that inhibits allergen-induced responses. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.1 kDa (Light Chain) & 53.5 kDa (Heavy Chain), under reducing conditions; 181.0kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 357613-86-6 |
Lumiliximab (anti-FceR2) (Ab177879) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling FceR2 (red) with Lumiliximab (anti-FceR2) (Ab177879). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Lumiliximab (anti-FceR2) (Ab177879) - SEC
The purity of Lumiliximab (anti-FceR2) (Ab177879) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ23F1101620 | Certificate of Analysis | Nov 08, 2023 | Ab177879 |
| ZJ23F1101621 | Certificate of Analysis | Nov 08, 2023 | Ab177879 |
| 1. Yokota A, Kikutani H, Tanaka T, Sato R, Barsumian EL, Suemura M, Kishimoto T. (1988) Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression.. Cell, 55 (4): (611-8). [PMID:2972386] [10.1021/op500134e] |
| 2. Rose, K K and 8 more authors.. (1992) Partial characterization of natural and recombinant human soluble CD23.. The Biochemical journal, (15): [PMID:1417742] |
| 3. Pirron, U U, Schlunck, T T, Prinz, J C JC and Rieber, E P EP.. (1990) IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE.. European journal of immunology, [PMID:2167225] |
| 4. Kikutani, H H and 9 more authors.. (1986) Molecular structure of human lymphocyte receptor for immunoglobulin E.. Cell, (5): [PMID:2877743] |
| 5. Ikuta, K K and 7 more authors.. (1987) Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2949326] |
| 6. Lüdin, C C and 8 more authors.. (1987) Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor.. The EMBO journal, [PMID:3034567] |
| 7. Vouldoukis, I I and 7 more authors.. (1995) The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen.. Proceedings of the National Academy of Sciences of the United States of America, (15): [PMID:7544003] |
| 8. Padlan, E A EA and Helm, B A BA.. (1993) Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23).. Receptor, [PMID:8142907] |
| 9. Bajorath, J J and Aruffo, A A.. (1996) Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.. Protein science : a publication of the Protein Society, [PMID:8745401] |
| 10. Hibbert, Richard G RG and 9 more authors.. (2005) The structure of human CD23 and its interactions with IgE and CD21.. The Journal of experimental medicine, (19): [PMID:16172256] |
| 11. Wurzburg, Beth A BA, Tarchevskaya, Svetlana S SS and Jardetzky, Theodore S TS.. (2006) Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.. Structure (London, England : 1993), [PMID:16765898] |
| 12. Lemieux, George A GA and 9 more authors.. (2007) The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.. The Journal of biological chemistry, (18): [PMID:17389606] |
| 13. Pathan, Nuzhat I NI and 5 more authors.. (2008) Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines.. Blood, (1): [PMID:18032710] |
| 14. Ivaldi, Corinne C and 6 more authors.. (2012) Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.. PloS one, [PMID:22615937] |
| 15. Hersheson, Joshua J and 17 more authors.. (2013) Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia.. Annals of neurology, [PMID:23424103] |
