Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L129349-10mg | 10mg | In stock | $78.90 | |
L129349-50mg | 50mg | In stock | $355.90 | |
L129349-100mg | 100mg | In stock | $639.90 | |
L129349-250mg | 250mg | In stock | $1,439.90 | |
L129349-1g | 1g | In stock | $5,183.90 |
Potent and selective COX-2 inhibitor
Synonyms | Lumiracoxib | 220991-20-8 | Prexige | COX-189 | Lumaricoxib | COX 189 | COX189 | Prexige;COX 189 | 2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid | 2-((2-Chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid | CHEMBL404108 | DTXSID9049035 | CHEBI:73044 | {2-[(2 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Lumaricoxib is a Cox-2 selective inhibitor NSAID member of the arylalkanoic acid family of NSAIDs. Lumaricoxib binds to a separate site than that of other Cox-2 inhibitors.Potent and selective COX-2 inhibitor (K i = 60 nM). Orally active. Anti-inflammator |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase-2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. |
ALogP | 4.2 |
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Pubchem Sid | 488188234 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488188234 |
IUPAC Name | 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid |
INCHI | InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20) |
InChi Key | KHPKQFYUPIUARC-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O |
Isomeric SMILES | CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O |
PubChem CID | 151166 |
Molecular Weight | 293.72 |
Wikipedia | Lumiracoxib |
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PubChem CID | 151166 |
ChEBI | CHEBI:524824 |
DrugBank Ligand | DB01283 |
CAS Registry No. | 220991-20-8 |
ChEMBL Ligand | CHEMBL404108 |
RCSB PDB Ligand | LUR |
DrugCentral Ligand | 1618 |
PubChem SID | 488188234 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
L1517117 | Certificate of Analysis | May 12, 2023 | L129349 |
E2317627 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317634 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317645 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317646 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317650 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317662 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317694 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317770 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317792 | Certificate of Analysis | Jan 05, 2023 | L129349 |
E2317905 | Certificate of Analysis | Jan 05, 2023 | L129349 |
Solubility | Soluble in DMSO (59 mg/ml), methanol, and ethanol (<1 mg/ml). Insoluble in water. |
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Melt Point(°C) | 136-138°C |