Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L107329-250mg | 250mg | In stock | $37.90 | |
L107329-500mg | 500mg | In stock | $64.90 | |
L107329-1g | 1g | In stock | $108.90 | |
L107329-5g | 5g | In stock | $423.90 | |
L107329-25g | 25g | In stock | $1,299.90 | |
L107329-100g | 100g | In stock | $3,699.90 |
Anti-inflammatory, antioxidant and free radical scavenger
Synonyms | 4dew | Cyanidenon 1470 | HMS3561N09 | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | C.I. Natural Yellow 2 | LUTEOLIN [WHO-DD] | BIDD:ER0122 | Flacitran | Luteolin, >=98% (TLC), powder | Luteolol | MLS006011917 | CCRIS 3790 | BCP9000865 | HMS335 |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α-induced COX-2 expression. Antiproliferative and chemopreventative; |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Note | 250mg售完停产 |
Product Description | Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T?CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488195204 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195204 |
IUPAC Name | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one |
INCHI | InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H |
InChi Key | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O |
Isomeric SMILES | C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O |
WGK Germany | 3 |
RTECS | LK9275210 |
PubChem CID | 5280445 |
Molecular Weight | 286.24 |
Beilstein | 292084 |
Reaxy-Rn | 292084 |
PubChem SID | 488195204 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J2428626 | Certificate of Analysis | Nov 02, 2024 | L107329 |
J2428584 | Certificate of Analysis | Nov 02, 2024 | L107329 |
J2428578 | Certificate of Analysis | Nov 02, 2024 | L107329 |
J2428577 | Certificate of Analysis | Nov 02, 2024 | L107329 |
D2430096 | Certificate of Analysis | May 11, 2024 | L107329 |
D2430095 | Certificate of Analysis | May 11, 2024 | L107329 |
D2430091 | Certificate of Analysis | May 11, 2024 | L107329 |
D2430090 | Certificate of Analysis | May 11, 2024 | L107329 |
D2430089 | Certificate of Analysis | May 11, 2024 | L107329 |
C2406170 | Certificate of Analysis | Mar 09, 2024 | L107329 |
C2406234 | Certificate of Analysis | Mar 09, 2024 | L107329 |
C2406169 | Certificate of Analysis | Mar 09, 2024 | L107329 |
C2406171 | Certificate of Analysis | Mar 09, 2024 | L107329 |
C2406232 | Certificate of Analysis | Mar 09, 2024 | L107329 |
C2406233 | Certificate of Analysis | Mar 09, 2024 | L107329 |
G2313848 | Certificate of Analysis | Jul 25, 2023 | L107329 |
G2313868 | Certificate of Analysis | Jul 25, 2023 | L107329 |
G2313878 | Certificate of Analysis | Jul 19, 2023 | L107329 |
G2313867 | Certificate of Analysis | Jul 19, 2023 | L107329 |
L2315075 | Certificate of Analysis | Jul 19, 2023 | L107329 |
G2313866 | Certificate of Analysis | Jul 19, 2023 | L107329 |
G2313859 | Certificate of Analysis | Jul 19, 2023 | L107329 |
D2325759 | Certificate of Analysis | May 10, 2023 | L107329 |
D2325758 | Certificate of Analysis | May 10, 2023 | L107329 |
D2325704 | Certificate of Analysis | May 10, 2023 | L107329 |
D2325757 | Certificate of Analysis | May 10, 2023 | L107329 |
D2325751 | Certificate of Analysis | May 09, 2023 | L107329 |
D2325762 | Certificate of Analysis | May 09, 2023 | L107329 |
D2325756 | Certificate of Analysis | May 09, 2023 | L107329 |
D2325752 | Certificate of Analysis | May 09, 2023 | L107329 |
D2325700 | Certificate of Analysis | May 08, 2023 | L107329 |
D2325744 | Certificate of Analysis | May 08, 2023 | L107329 |
D2325755 | Certificate of Analysis | May 08, 2023 | L107329 |
D2325745 | Certificate of Analysis | May 08, 2023 | L107329 |
L1806184 | Certificate of Analysis | Sep 22, 2022 | L107329 |
L1807023 | Certificate of Analysis | Sep 21, 2022 | L107329 |
F2215581 | Certificate of Analysis | Jun 18, 2022 | L107329 |
F2215582 | Certificate of Analysis | Jun 18, 2022 | L107329 |
F2215580 | Certificate of Analysis | Jun 18, 2022 | L107329 |
F2215579 | Certificate of Analysis | Jun 18, 2022 | L107329 |
F2215578 | Certificate of Analysis | Jun 18, 2022 | L107329 |
D2101255 | Certificate of Analysis | Apr 25, 2021 | L107329 |
Solubility | Solvent:1eq. NaOH, Max Conc. mg/mL: 1.43, Max Conc. mM: 5; Solvent:DMSO, Max Conc. mg/mL: 14.31, Max Conc. mM: 50 |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 330°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | LK9275210 |
Reaxy-Rn | 292084 |
Merck Index | 5614 |
1. Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu. (2024) Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury. TOXICON, 237 (1): (107531). [PMID:38013056] [10.1016/j.toxicon.2023.107531] |
2. Ziyuan Deng, Chengling Lai, Jun Zhang, Fan Sun, Danting Li, Peiying Hao, Xuping Shentu, Kun Pang, Xiaoping Yu. (2024) Effects of Secondary Metabolites of Rice on Brown Planthopper and Its Symbionts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (1): (386). [PMID:38203556] [10.3390/ijms25010386] |
3. Jingjing Zhen, Faguang Ma, Jing Yan, Rongxin Lin, Ming Yan, Yilin Wu. (2024) Synthesis of metal-organic framework hybrid nanocomposites based on MOFs@C3N4 with high selective separation ability for luteolin. SEPARATION AND PURIFICATION TECHNOLOGY, 335 (126139). [PMID:] [10.1016/j.seppur.2023.126139] |
4. Shucheng Liu, Zhi Hu, Xuan Zhang, Hao Huang, Jianming Pan, Hongxiang Ou. (2024) Fabrication of double imprinted anchor points in cellulose nanocrystals-based hierarchical porous polyHIPEs for selective separation of flavoniods under physiological pH. JOURNAL OF HAZARDOUS MATERIALS, 465 (133230). [PMID:38134695] [10.1016/j.jhazmat.2023.133230] |
5. Guo Zhonghui, Li Jieming, Luo Di, Zhang Mingxia. (2023) Novel ecological implications of non-toxic Microcystis towards toxic ecotype in population—promoting toxic ecotype dominance at various N levels and cooperative defense against luteolin-stress. FEMS MICROBIOLOGY ECOLOGY, 99 (12): [PMID:37884453] [10.1093/femsec/fiad138] |
6. Yueqin Li, Yunzhen Zhang, Lezhen Dong, Ying Li, Yahui Liu, Yang Liu, Lingyi Liu, Lianliang Liu. (2024) Fermentation of Lactobacillus fermentum NB02 with feruloyl esterase production increases the phenolic compounds content and antioxidant properties of oat bran. FOOD CHEMISTRY, 437 (15): (137834). [PMID:37897817] [10.1016/j.foodchem.2023.137834] |
7. Faguang Ma, Ming Yan, Rongxin Lin, Yilin Wu, Jianming Pan. (2024) Boronate-affinity sol–gel-imprinted membranes with MOFs-functionalized rotary-evaporating layers for high-precision specific recognition. SEPARATION AND PURIFICATION TECHNOLOGY, 330 (125458). [PMID:8107964] [10.1016/j.seppur.2023.125458] |
8. Liwei Xue, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Xiaoju Zhuge, Fang Xu, Zijiao Quan, Haibin Tong, Weilai Yu. (2023) Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis. INTERNATIONAL IMMUNOPHARMACOLOGY, 124 (3): (110996). [PMID:37776768] [10.1016/j.intimp.2023.110996] |
9. Yang You, Yipu Liu, Chuchu Ma, Jianpei Xu, Laozhi Xie, Shiqiang Tong, Yinzhe Sun, Fenfen Ma, Yukun Huang, Junbin Liu, Wenze Xiao, Chengxiang Dai, Suke Li, Jigang Lei, Qiyong Mei, Xiaoling Gao, Jun Chen. (2023) Surface-tethered ROS-responsive micelle backpacks for boosting mesenchymal stem cell vitality and modulating inflammation in ischemic stroke treatment. JOURNAL OF CONTROLLED RELEASE, 362 (210). [PMID:37619863] [10.1016/j.jconrel.2023.08.039] |
10. Dan Wang, He Li, Tian-Yu Hou, Zhi-Jun Zhang, Hui-Zhen Li. (2023) Effects of conjugated interactions between Perilla seed meal proteins and different polyphenols on the structural and functional properties of proteins. FOOD CHEMISTRY, (137345). [PMID:37666124] [10.1016/j.foodchem.2023.137345] |
11. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259] [10.1016/j.chroma.2023.464324] |
12. Song Jie, Zhang Rong, Han Jiaxuan, Dou Yufang, Yu Shuang, Ma Xiaoyan. (2023) Preparation and Performance Study of Polybutylene Succinate/Esterified Modified Luteolin Composite Materials. JOURNAL OF POLYMERS AND THE ENVIRONMENT, (1-14). [PMID:] [10.1007/s10924-023-03001-x] |
13. Mubashar Hassan, Yanan Wang, Shahid Ali Rajput, Aftab Shaukat, Ping Yang, Muhammad Zahid Farooq, Qianhui Cheng, Mehboob Ali, Xiaomei Mi, Yu An, Desheng Qi. (2023) Ameliorative Effects of Luteolin and Activated Charcoal on Growth Performance, Immunity Function, and Antioxidant Capacity in Broiler Chickens Exposed to Deoxynivalenol. Toxins, 15 (8): (478). [PMID:37624235] [10.3390/toxins15080478] |
14. Dong Li, Chunran Zhou, Shuai Wang, Zhan Hu, Jia Xie, Canping Pan, Ranfeng Sun. (2023) Imidacloprid-induced stress affects the growth of pepper plants by disrupting rhizosphere-plant microbial and metabolite composition. SCIENCE OF THE TOTAL ENVIRONMENT, 898 (165395). [PMID:37437628] [10.1016/j.scitotenv.2023.165395] |
15. Renjie Li, Jin Chen, Huihui Li, Zhuangwei Zhang, Hongjin Tang. (2023) Effects of calcium ions on the particle performance of luteolin-loaded zein-gum arabic-tea polyphenols ternary complex nanoparticles. LWT-FOOD SCIENCE AND TECHNOLOGY, 184 (115057). [PMID:] [10.1016/j.lwt.2023.115057] |
16. Saif Ullah, Gang Hu, Mati Ur Rahman, Asif Hayat, Ata Ur Rehman, Ijaz Ullah, Akhlaq Ahmad, Waqar Uddin, Wen Ma, Zhaohui Fang, Muhammad Yasir Nawabi, Rooh Ullah, Jimei Song. (2019) Evaluation of Antioxidants Activity of Some Natural Polyphenolic Compounds By using Briggs-Rauscher Reaction. International Journal of Electrochemical Science, 14 (10176). [PMID:] [10.20964/2019.11.39] |
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