Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L132758-5mg | 5mg | In stock | $177.90 | |
L132758-25mg | 25mg | In stock | $801.90 | |
L132758-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,883.90 |
Competitive melatonin receptor antagonist
Synonyms | 2-Benzyl-N-acetyltryptamine | HMS3411B10 | N-(2-(2-(PHENYLMETHYL)-1H-INDOL-3-YL)ETHYL)ETHANAMIDE | AM20020263 | Q6706607 | NCGC00024838-01 | GTPL1363 | N 0774 | Luzindole, >=90% | N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide | N-[2-(2-Benzyl-1H-indol-3-yl |
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Specifications & Purity | Moligand™, ≥96% |
Biochemical and Physiological Mechanisms | Melatonin receptor antagonist.Competitive melatonin receptor antagonist (IC 50 = 1 μM). Shows selectivity towards melatonin 1B (K i values are 45 and 603 nM for MEL-1B and MEL-1A respectively). Inhibits melatonin-induced pigment aggregation (IC 50 = 2.1 μ |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of MT 1 receptor;Antagonist of MT 2 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide |
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INCHI | InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) |
InChi Key | WVVXBPKOIZGVNS-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3 |
Isomeric SMILES | CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3 |
PubChem CID | 122162 |
Molecular Weight | 292.37 |
PubChem CID | 122162 |
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ChEMBL Ligand | CHEMBL286615 |
Wikipedia | Luzindole |
CAS Registry No. | 117946-91-5 |
GPCRdb Ligand | luzindole |
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Solubility | Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water. |
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Sensitivity | heat sensitive |
Melt Point(°C) | 106 °C |
1. Jiang S et al.. (2021) Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats.. J Inflamm Res, 14 (5919-5937). [PMID:34803390] |
2. Zhou Q et al.. (2021) Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide.. Mol Neurobiol, 58 (12): (6552-6576). [PMID:34585328] |
3. Shuai Y et al.. (2016) Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.. Theranostics, 6 (11): (1899-917). [PMID:27570559] |