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Luzindole - 96%, high purity , CAS No.117946-91-5, Antagonist of MT 1 receptor;Antagonist of MT 2 receptor

Moligand™
≥96%

CAS#: 117946-91-5
Formula: C₁₉H₂₀N₂O
Molecular Weight: 292.37
MDL number: MFCD00672498
PubChem CID: 122162

Item Number

L132758

Grouped product items
SKU	Size	Availability	Price
L132758-5mg	5mg	In stock	$177.90
L132758-25mg	25mg	In stock	$801.90
L132758-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,883.90

Competitive melatonin receptor antagonist

View related series

MT1 receptor Antagonist MT2 receptor Antagonist

Basic Description

Synonyms	luzindole\|117946-91-5\|N-Acetyl-2-benzyltryptamine\|2-Benzyl-N-acetyltryptamine\|N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide\|N-Acetyl-2-benzyl-tryptamine\|N 0774\|N-0774\|N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide\|B31Y10A9UR\|Acetamide, N-(2-(2-(pheny
Specifications & Purity	96%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of MT 1 receptor;Antagonist of MT 2 receptor

Associated Targets

MTNR1A Tclin Melatonin receptor type 1A 0 Activities

Discover Target: MTNR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MTNR1B Tclin Melatonin receptor type 1B 3 Activities

Discover Target: MTNR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[2-(2-benzyl-1H-indol-3-yl)ethyl]acetamide
INCHI	InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
InChi Key	WVVXBPKOIZGVNS-UHFFFAOYSA-N
Canonical SMILES	CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3
Isomeric SMILES	CC(=O)NCCC1=C(NC2=CC=CC=C21)CC3=CC=CC=C3
PubChem CID	122162
Molecular Weight	292.37

PubChem CID

ChEMBL Ligand

Wikipedia

CAS Registry No.

GPCRdb Ligand

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
D2117235	Certificate of Analysis	Feb 08, 2023	L132758
D2117236	Certificate of Analysis	Feb 08, 2023	L132758
D2117239	Certificate of Analysis	Feb 08, 2023	L132758

Solubility

Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water.

Sensitivity

heat sensitive

Melt Point(°C)

106 °C

References

1. Jiang S et al.. (2021) Melatonin Ameliorates Axonal Hypomyelination of Periventricular White Matter by Transforming A1 to A2 Astrocyte via JAK2/STAT3 Pathway in Septic Neonatal Rats.. J Inflamm Res, 14 (5919-5937). [PMID:34803390]
2. Zhou Q et al.. (2021) Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide.. Mol Neurobiol, 58 (12): (6552-6576). [PMID:34585328]
3. Shuai Y et al.. (2016) Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.. Theranostics, 6 (11): (1899-917). [PMID:27570559]

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