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LW106 , CAS No.L611627, Inhibitor of indoleamine 2;3-dioxygenase 1

Item Number

L611627

Grouped product items
SKU	Size	Availability	Price	Qty
L611627-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611627-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of indoleamine 2;3-dioxygenase 1

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	4-[(E)-(2,3-dihydro-1H-isoindol-2-yl)(hydroxyimino)methyl]-1,2,5-oxadiazol-3-amine
INCHI	InChI=1S/C11H11N5O2/c12-10-9(14-18-15-10)11(13-17)16-5-7-3-1-2-4-8(7)6-16/h1-4,17H,5-6H2,(H2,12,15)/b13-11+
InChi Key	QHVIXMMITPHBSL-ACCUITESSA-N
Canonical SMILES	O/N=C(\c1nonc1N)/N1Cc2c(C1)cccc2
Isomeric SMILES	C1C2=CC=CC=C2CN1/C(=N\O)/C3=NON=C3N
PubChem CID	137253428

PubChem CID	137253428

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1. Yue EW, Douty B, Wayland B, Bower M, Liu X, Leffet L, Wang Q, Bowman KJ, Hansbury MJ, Liu C et al.. (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.. J Med Chem, 52 (23): (7364-7). [PMID:19507862] [10.1021/op500134e]
2. Fu R, Zhang YW, Li HM, Lv WC, Zhao L, Guo QL, Lu T, Weiss SJ, Li ZY, Wu ZQ. (2018) LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment.. Br J Pharmacol, 175 (14): (3034-3049). [PMID:29722898] [10.1021/op500134e]

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