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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L288127-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $39.90 | |
L288127-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $112.90 | |
L288127-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $203.90 | |
L288127-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $352.90 | |
L288127-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $639.90 | |
L288127-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,159.90 |
Allosteric potentiator of α7, α4β2 and α4β4 nAChRs
Synonyms | [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienyl-methanone | (2-Amino-5-keto)thiazole) |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Allosteric potentiator ofα7,α4β2 andα4β4 nAChRs; displays selectivity againstα3β4 nAChRs. Thought to potentiate agonist-evokedα7 responses by binding within the nAChR transmembrane region.LY 2087101 is a selective positive allosteric potentiator of α7 an |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of nicotinic acetylcholine receptor α2 subunit;Allosteric modulator of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | [2-(4-fluoroanilino)-4-methyl-1,3-thiazol-5-yl]-thiophen-3-ylmethanone |
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INCHI | InChI=1S/C15H11FN2OS2/c1-9-14(13(19)10-6-7-20-8-10)21-15(17-9)18-12-4-2-11(16)3-5-12/h2-8H,1H3,(H,17,18) |
InChi Key | PEAMDZVDNYENPN-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(SC(=N1)NC2=CC=C(C=C2)F)C(=O)C3=CSC=C3 |
Isomeric SMILES | CC1=C(SC(=N1)NC2=CC=C(C=C2)F)C(=O)C3=CSC=C3 |
PubChem CID | 11964458 |
Molecular Weight | 318.39 |
PubChem CID | 11964458 |
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CAS Registry No. | 913186-74-0 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2410416 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410442 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410446 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410447 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410448 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410450 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410452 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410453 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410457 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410458 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410461 | Certificate of Analysis | May 29, 2024 | L288127 |
G2410462 | Certificate of Analysis | May 29, 2024 | L288127 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 31.84, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.18, Max Conc. mM: 10 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |