LY 2087101 - 98%, high purity , CAS No.913186-74-0, Allosteric modulator of nicotinic acetylcholine receptor α2 subunit;Allosteric modulator of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Item Number
L288127
Grouped product items
SKUSizeAvailabilityPrice Qty
L288127-1mg
1mg
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$39.90
L288127-5mg
5mg
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$112.90
L288127-10mg
10mg
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$203.90
L288127-25mg
25mg
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$352.90
L288127-50mg
50mg
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$639.90
L288127-100mg
100mg
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$1,159.90

Allosteric potentiator of α7, α4β2 and α4β4 nAChRs

Basic Description

Synonyms[2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienyl-methanone | (2-Amino-5-keto)thiazole)
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsAllosteric potentiator ofα7,α4β2 andα4β4 nAChRs; displays selectivity againstα3β4 nAChRs. Thought to potentiate agonist-evokedα7 responses by binding within the nAChR transmembrane region.LY 2087101 is a selective positive allosteric potentiator of α7 an
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of nicotinic acetylcholine receptor α2 subunit;Allosteric modulator of nicotinic acetylcholine receptor α4 subunit;Allosteric modulator of nicotinic acetylcholine receptor α7 subunit

Associated Targets(Human)

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRNA4 Tclin Neuronal acetylcholine receptor subunit alpha-4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRNA2 Tchem Neuronal acetylcholine receptor subunit alpha-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name [2-(4-fluoroanilino)-4-methyl-1,3-thiazol-5-yl]-thiophen-3-ylmethanone
INCHI InChI=1S/C15H11FN2OS2/c1-9-14(13(19)10-6-7-20-8-10)21-15(17-9)18-12-4-2-11(16)3-5-12/h2-8H,1H3,(H,17,18)
InChi Key PEAMDZVDNYENPN-UHFFFAOYSA-N
Canonical SMILES CC1=C(SC(=N1)NC2=CC=C(C=C2)F)C(=O)C3=CSC=C3
Isomeric SMILES CC1=C(SC(=N1)NC2=CC=C(C=C2)F)C(=O)C3=CSC=C3
PubChem CID 11964458
Molecular Weight 318.39

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
G2410416Certificate of AnalysisMay 29, 2024 L288127
G2410442Certificate of AnalysisMay 29, 2024 L288127
G2410446Certificate of AnalysisMay 29, 2024 L288127
G2410447Certificate of AnalysisMay 29, 2024 L288127
G2410448Certificate of AnalysisMay 29, 2024 L288127
G2410450Certificate of AnalysisMay 29, 2024 L288127
G2410452Certificate of AnalysisMay 29, 2024 L288127
G2410453Certificate of AnalysisMay 29, 2024 L288127
G2410457Certificate of AnalysisMay 29, 2024 L288127
G2410458Certificate of AnalysisMay 29, 2024 L288127
G2410461Certificate of AnalysisMay 29, 2024 L288127
G2410462Certificate of AnalysisMay 29, 2024 L288127

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 31.84, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.18, Max Conc. mM: 10

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

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