Prototypical PI 3-kinase inhibitor (IC50values are 0.31, 0.73, 1.06 and 6.60μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδand PI 3-Kγrespectively). Also inhibits other kinases including, CK2, mTOR, PLK1, PIM1 and PIM3. Inhibits proliferation and induces apoptosis in hu
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Product Description
Product Describtion:
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
Product Application：
LY-294,002 hydrochloride has been used in the inhibition of:
phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
autophagy in mesenchymal stem cells (MSCs).
serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.
C2328742