LY 294002 (DMSO solution) - ≥98%，10mM in DMSO, high purity , CAS No.154447-36-6, Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kina
LY 294002 (DMSO solution) - ≥98%，10mM in DMSO, high purity , CAS No.154447-36-6, Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kina
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC 50 > 50 μM). Also available as a solid .
Storage Temp
Protected from light,Desiccated,Store at -80°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of bromodomain containing 2;Inhibitor of bromodomain containing 3;Inhibitor of bromodomain containing 4;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha;Inhibitor of phosphatidylinositol-4;5-bisphosphate 3-kina
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
1.Dittmann A, Werner T, Chung CW, Savitski MM, Fälth Savitski M, Grandi P, Hopf C, Lindon M, Neubauer G, Prinjha RK et al.. (2014) The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.. ACS Chem Biol, 9 (2):(495-502). [PMID:24533473]
2.Vlahos CJ, Matter WF, Hui KY, Brown RF. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).. J Biol Chem, 269 (7):(5241-8). [PMID:8106507]
3.Lan T et al.. (2022) Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway.. BMC Pharmacol Toxicol, 23 (82). [PMID:36280856]
4.Ma K & Zhang C. (2022) HER4 Promotes Osteosarcoma Progression and Predicts Poor Prognosis through the PTEN-PI3K/AKT Pathway.. J Cancer, 13 (290-303). [PMID:34976190]
5.Wei S et al.. (2018) Novel Zinc Finger Transcription Factor ZFP580 Facilitates All-Trans Retinoic Acid -Induced Vascular Smooth Muscle Cells Differentiation by Rara-Mediated PI3K/Akt and ERK Signaling.. Cell Physiol Biochem, 50 (6):(2390-2405). [PMID:30423583]
6.Hao Y et al.. (2019) Piceatannol Protects Human Retinal Pigment Epithelial Cells against Hydrogen Peroxide Induced Oxidative Stress and Apoptosis through Modulating PI3K/Akt Signaling Pathway.. Nutrients, 11 (7):[PMID:31277394]
7.Xing Y et al.. (2019) ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway.. Int J Oncol, 54 (5):(1691-1703). [PMID:30816443]
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K2215032