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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
L288815-5mg | 5mg | In stock | $53.90 | |
L288815-10mg | 10mg | In stock | $97.90 | |
L288815-25mg | 25mg | In stock | $227.90 | |
L288815-50mg | 50mg | In stock | $434.90 | |
L288815-100mg | 100mg | In stock | $739.90 | |
L288815-250mg | 250mg | In stock | $1,665.90 |
Potent pan-Raf kinase inhibitor
Synonyms | 1454682-72-4 | C72761 | Pan-raf inhibitor ly3009120 | SCHEMBL15241297 | 1-(3,3-dimethylbutyl)-3-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea | B2693-470864 | 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2 |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | LY3009120 is an orally active, potent and selective pan-RAF type II inhibitor (IC50 = 4.3 nM/CRAF (c-Raf, Raf-1), 5.8 nM/BRAF(V600E), 15 nM/BRAF (b-Raf) by kinase assay with 1 mM ATP; IC50 = 44 nM/ARAF, 31-47 nM/BRAF, 42 nM/CRAF, >1 μM/155 other kinases b |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of A-Raf proto-oncogene; serine/threonine kinase;Inhibitor of B-Raf proto-oncogene; serine/threonine kinase;Inhibitor of Raf-1 proto-oncogene; serine/threonine kinase |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | Expert: [1] | |
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | ||
Tyrosine-protein kinase ABL inhibitor | INHIBITOR | ALA1862 | Tyrosine-protein kinase ABL | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
Pubchem Sid | 488202289 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202289 |
IUPAC Name | 1-(3,3-dimethylbutyl)-3-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea |
INCHI | InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30) |
InChi Key | HHCBMISMPSAZBF-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F |
Isomeric SMILES | CC1=CC(=C(C=C1C2=C(N=C3C(=C2)C=NC(=N3)NC)C)NC(=O)NCCC(C)(C)C)F |
PubChem CID | 71721540 |
Molecular Weight | 424.52 |
Find and download the COA for your product by matching the lot number on the packaging.
12 results found
Lot Number | Certificate Type | Date | Item |
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D23141756 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141764 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141769 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141772 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141776 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141777 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141784 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141785 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141798 | Certificate of Analysis | Mar 07, 2023 | L288815 |
D23141981 | Certificate of Analysis | Mar 07, 2023 | L288815 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 4.25, Max Conc. mM: 10 with gentle warming |
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Starting at $172.90
1. Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y et al.. (2015) Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.. Cancer Cell, 28 (3): (384-98). [PMID:26343583] [10.1021/op500134e] |