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(±)-LY 395756 - ≥98%(HPLC), high purity , CAS No.852679-66-4, Agonist of mGlu 2 receptor;Antagonist of mGlu 3 receptor

Item Number
L288487
Grouped product items
SKUSizeAvailabilityPrice Qty
L288487-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$216.90
L288487-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$893.90

Mixed mGlu2agonist/ mGlu3antagonist

Basic Description

Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsSelective metabotropic glutamate ligand for mGlu2and mGlu3receptors (Kivalues are 0.165μM and 0.302μM respectively). Acts as an agonist at mGlu2and antagonist at mGlu3. Analog ofLY 354740.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionAgonist of mGlu 2 receptor;Antagonist of mGlu 3 receptor

Associated Targets(Human)

GRM2 Tchem Metabotropic glutamate receptor 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM3 Tchem Metabotropic glutamate receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM3 Tchem Metabotropic glutamate receptor 3 (732 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Metabotropic glutamate receptor 3 agonistAGONISTALA2888Metabotropic glutamate receptor 3SINGLE PROTEINHomo sapiens

PubMed: [1]


Metabotropic glutamate receptor 3 agonistAGONISTALA2888Metabotropic glutamate receptor 3SINGLE PROTEINHomo sapiens

Other: [1]


Metabotropic glutamate receptor 3 modulatorMODULATORALA2888Metabotropic glutamate receptor 3SINGLE PROTEINHomo sapiens

Wikipedia: [1]


Metabotropic glutamate receptor 3 agonistAGONISTALA2888Metabotropic glutamate receptor 3SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Names and Identifiers

IUPAC Name (1S,2S,4R,5R,6S)-2-amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
INCHI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
InChi Key BQVZICWQBFTOJX-QNDZYWSYSA-N
Canonical SMILES CC1CC(C2C1C2C(=O)O)(C(=O)O)N
Isomeric SMILES C[C@@H]1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N
PubChem CID 11310142
MeSH Entry Terms 2-amino-4-methylbicyclo(3.1.0)hexane-2,6-dicarboxylic acid;2-amino-4-methylbicyclo(3.1.0)hexane2,6-dicarboxylic acid;LY395756;LY541850
Molecular Weight 199.21

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilitySolvent:1eq. HCl, Max Conc. mg/mL: 19.92, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 19.92, Max Conc. mM: 100

Related Documents

References

1. Li ML, Yang SS, Xing B, Ferguson BR, Gulchina Y, Li YC, Li F, Hu XQ, Gao WJ.  (2015)  LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment..  Exp Neurol,  273  (13): (190-201).  [PMID:26341392] [10.1021/op500134e]

Solution Calculators