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(±)-LY 395756 - ≥98%(HPLC), high purity , CAS No.852679-66-4, Agonist of mGlu 2 receptor;Antagonist of mGlu 3 receptor

Moligand™
≥98%(HPLC)

CAS#: 852679-66-4
Formula: C₉H₁₃NO₄
Molecular Weight: 199.21
PubChem CID: 11310142

Item Number

L288487

Grouped product items
SKU	Size	Availability	Price	Qty
L288487-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$216.90
L288487-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$893.90

Mixed mGlu2agonist/ mGlu3antagonist

View related series

mGlu2 receptor Agonist mGlu3 receptor Antagonist

Basic Description

Synonyms	(1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective metabotropic glutamate ligand for mGlu2and mGlu3receptors (Kivalues are 0.165μM and 0.302μM respectively). Acts as an agonist at mGlu2and antagonist at mGlu3. Analog ofLY 354740.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Agonist of mGlu 2 receptor;Antagonist of mGlu 3 receptor

Associated Targets

GRM2 Tchem Metabotropic glutamate receptor 2 0 Activities

Discover Target: GRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

Discover Target: GRM8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM3 Tchem Metabotropic glutamate receptor 3 0 Activities

Discover Target: GRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM6 Tchem Metabotropic glutamate receptor 6 0 Activities

Discover Target: GRM6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1S,2S,4R,5R,6S)-2-amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
INCHI	InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
InChi Key	BQVZICWQBFTOJX-QNDZYWSYSA-N
Canonical SMILES	CC1CC(C2C1C2C(=O)O)(C(=O)O)N
Isomeric SMILES	C[C@@H]1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N
PubChem CID	11310142
MeSH Entry Terms	2-amino-4-methylbicyclo(3.1.0)hexane-2,6-dicarboxylic acid;2-amino-4-methylbicyclo(3.1.0)hexane2,6-dicarboxylic acid;LY395756;LY541850
Molecular Weight	199.21

References

1. Li ML, Yang SS, Xing B, Ferguson BR, Gulchina Y, Li YC, Li F, Hu XQ, Gao WJ. (2015) LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.. Exp Neurol, 273 (3): (190-201). [PMID:26341392]

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