My Cart
You have no items in your shopping cart.
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
L288487-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $216.90 | |
L288487-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $893.90 |
Mixed mGlu2agonist/ mGlu3antagonist
Specifications & Purity | Moligand™, ≥98%(HPLC) |
---|---|
Biochemical and Physiological Mechanisms | Selective metabotropic glutamate ligand for mGlu2and mGlu3receptors (Kivalues are 0.165μM and 0.302μM respectively). Acts as an agonist at mGlu2and antagonist at mGlu3. Analog ofLY 354740. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of mGlu 2 receptor;Antagonist of mGlu 3 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
---|
Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 3 agonist | AGONIST | ALA2888 | Metabotropic glutamate receptor 3 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Metabotropic glutamate receptor 3 agonist | AGONIST | ALA2888 | Metabotropic glutamate receptor 3 | SINGLE PROTEIN | Homo sapiens | Other: [1] | |
Metabotropic glutamate receptor 3 modulator | MODULATOR | ALA2888 | Metabotropic glutamate receptor 3 | SINGLE PROTEIN | Homo sapiens | Wikipedia: [1] | |
Metabotropic glutamate receptor 3 agonist | AGONIST | ALA2888 | Metabotropic glutamate receptor 3 | SINGLE PROTEIN | Homo sapiens |
IUPAC Name | (1S,2S,4R,5R,6S)-2-amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
---|---|
INCHI | InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1 |
InChi Key | BQVZICWQBFTOJX-QNDZYWSYSA-N |
Canonical SMILES | CC1CC(C2C1C2C(=O)O)(C(=O)O)N |
Isomeric SMILES | C[C@@H]1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N |
PubChem CID | 11310142 |
MeSH Entry Terms | 2-amino-4-methylbicyclo(3.1.0)hexane-2,6-dicarboxylic acid;2-amino-4-methylbicyclo(3.1.0)hexane2,6-dicarboxylic acid;LY395756;LY541850 |
Molecular Weight | 199.21 |
Solubility | Solvent:1eq. HCl, Max Conc. mg/mL: 19.92, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 19.92, Max Conc. mM: 100 |
---|
1. Li ML, Yang SS, Xing B, Ferguson BR, Gulchina Y, Li YC, Li F, Hu XQ, Gao WJ. (2015) LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment.. Exp Neurol, 273 (13): (190-201). [PMID:26341392] [10.1021/op500134e] |