Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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L275852-1mg | 1mg | In stock | $33.90 | |
L275852-5mg | 5mg | In stock | $137.90 | |
L275852-10mg | 10mg | In stock | $236.90 | |
L275852-25mg | 25mg | In stock | $474.90 | |
L275852-50mg | 50mg | In stock | $791.90 | |
L275852-100mg | 100mg | In stock | $1,484.90 |
Selective, competitive BLT2 receptor antagonist
Synonyms | BDBM81519 | CS-0008561 | DTXSID30151872 | J-003652 | LY255283;LY-255283;CGS 23356 | NCGC00092338-01 | 1-[5-ETHYL-2-HYDROXY-4-[[6-METHYL-6-(1H-TETRAZOL-5-YL)HEPTYL]OXY]PHENYL]ETHANONE | HMS3268D04 | HY-15744 | SODIUM TETRADECYL SULFATE [MART.] | (1-(5-Ethy |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Selective, competitive BLT2 receptor antagonist (IC 50 values are 1 and 10 μM for BLT2 and BLT1 respectively). Shows antiasthmatic effects in vivo. Orally active. |
Storage Temp | Store at -20°C,Argon charged,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of BLT 1 receptor;Antagonist of BLT 2 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-[5-ethyl-2-hydroxy-4-[6-methyl-6-(2H-tetrazol-5-yl)heptoxy]phenyl]ethanone |
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INCHI | InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23) |
InChi Key | WCGXJPFHTHQNJL-UHFFFAOYSA-N |
Canonical SMILES | CCC1=CC(=C(C=C1OCCCCCC(C)(C)C2=NNN=N2)O)C(=O)C |
Isomeric SMILES | CCC1=CC(=C(C=C1OCCCCCC(C)(C)C2=NNN=N2)O)C(=O)C |
PubChem CID | 122023 |
Molecular Weight | 360.5 |
CAS Registry No. | 117690-79-6 |
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PubChem CID | 35025716 |
GPCRdb Ligand | LY255283 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2317242 | Certificate of Analysis | May 09, 2024 | L275852 |
F2317340 | Certificate of Analysis | Apr 11, 2024 | L275852 |
F2317293 | Certificate of Analysis | Apr 11, 2024 | L275852 |
F2317290 | Certificate of Analysis | Apr 11, 2024 | L275852 |
F2317263 | Certificate of Analysis | Apr 11, 2024 | L275852 |
F2317244 | Certificate of Analysis | Apr 11, 2024 | L275852 |
F2317238 | Certificate of Analysis | Apr 02, 2024 | L275852 |
F2317240 | Certificate of Analysis | Apr 02, 2024 | L275852 |
F2317241 | Certificate of Analysis | Apr 02, 2024 | L275852 |
F2317255 | Certificate of Analysis | Apr 02, 2024 | L275852 |
F2317281 | Certificate of Analysis | Apr 02, 2024 | L275852 |
F2317287 | Certificate of Analysis | Apr 02, 2024 | L275852 |
Solubility | Soluble in ethanol to 25 mM and in DMSO to 100 mM |
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Starting at $241.90
1. Richards IM, Sun FF, Taylor BM, Shields SK, Griffin RL, Morris J, Wishka DG, Smith HW, Johnson RA, Dunn CJ. (1991) Contribution of leukotriene B4 to airway inflammation and the effect of antagonists.. Ann N Y Acad Sci, 629 (13): (274-87). [PMID:1659282] [10.1021/op500134e] |
2. Lewis A & Elks PM. (2019) Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo.. Front Immunol, 10 (2321). [PMID:31611882] |