Potent and selective Chk1 inhibitor (IC50= 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in com
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Serine/threonine-protein kinase Chk1 inhibitor
Note
卖完停产，不再备货
Product Description
LY2603618 is a selective Chk1 inhibitor with potential anti-tumor activity. Phase 2. A selective Chk1 inhibitor.
1.Dai Y, Grant S. (2010) New insights into checkpoint kinase 1 in the DNA damage response signaling network.. Clin Cancer Res, 16 (2):(376-83). [PMID:20068082]
2.Govindan R. (2011) Summary of presentation from the targeted therapy in lung cancer meeting.. J Thorac Oncol, 6 (11 Suppl 4):(S1757). [PMID:22005528]
3.King C, Diaz H, Barnard D, Barda D, Clawson D, Blosser W, Cox K, Guo S, Marshall M. (2014) Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.. Invest New Drugs, 32 (2):(213-26). [PMID:24114124]
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J1521093