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LY2784544 - ≥98%, high purity , Tyrosine-protein kinase JAK2 inhibitor, CAS No.1229236-86-5, Tyrosine-protein kinase JAK2 inhibitor

Moligand™
≥98%

CAS#: 1229236-86-5
Formula: C₂₃H₂₅ClFN₇O
Molecular Weight: 469.95
PubChem CID: 46213929

Item Number

L126490

Grouped product items
SKU	Size	Availability	Price
L126490-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
L126490-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$107.90
L126490-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$412.90

View related series

Janus kinase 2 Inhibitor Janus kinase 3 Inhibitor

Basic Description

Synonyms	GANDOTINIB\|1229236-86-5\|LY2784544\|LY 2784544\|LY-2784544\|Gandotinib (LY2784544)\|3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine\|Gandotinib [USAN]\|Gandotinib(LY2784544)\|ANC71R916O\|Gandoti
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	LY2784544 is identified as being highly selective inhibitor of JAK2 mutant V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Tyrosine-protein kinase JAK2 inhibitor
Note	卖完停产，不再备货
Product Description	LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2. A selective inhibitor of JAK2 mutant V617F.

Associated Targets

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 1 Activities

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIRT6 Tchem NAD-dependent protein deacetylase sirtuin-6 0 Activities

Discover Target: SIRT6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIMK1 Tchem LIM domain kinase 1 0 Activities

Discover Target: LIMK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LIMK2 Tchem LIM domain kinase 2 0 Activities

Discover Target: LIMK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 1 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 1 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine
INCHI	InChI=1S/C23H25ClFN7O/c1-14-9-21(29-28-14)27-22-11-17(13-31-5-7-33-8-6-31)23-26-15(2)20(32(23)30-22)10-16-3-4-18(24)12-19(16)25/h3-4,9,11-12H,5-8,10,13H2,1-2H3,(H2,27,28,29,30)
InChi Key	SQSZANZGUXWJEA-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
Isomeric SMILES	CC1=CC(=NN1)NC2=NN3C(=C(N=C3C(=C2)CN4CCOCC4)C)CC5=C(C=C(C=C5)Cl)F
PubChem CID	46213929
Molecular Weight	469.95

CAS Registry No.

1229236-86-5

PubChem CID

46213929

ChEMBL Ligand

CHEMBL2107823

Certificates

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1 results found

Lot Number	Certificate Type	Date	Item
J1521094	Certificate of Analysis	May 10, 2023	L126490

References

1. Ma L, Clayton JR, Walgren RA, Zhao B, Evans RJ, Smith MC, Heinz-Taheny KM, Kreklau EL, Bloem L, Pitou C et al.. (2013) Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F.. Blood Cancer J, 3 (3): (e109). [PMID:23584399]
2. Berdeja J, Palandri F, Baer MR, Quick D, Kiladjian JJ, Martinelli G, Verma A, Hamid O, Walgren R, Pitou C et al.. (2018) Phase 2 study of gandotinib (LY2784544) in patients with myeloproliferative neoplasms.. Leuk Res, 71 (3): (82-88). [PMID:30025280]

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