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LY2812223 - ≥98.0%, high purity , CAS No.1311385-20-2
Basic Description Specifications & Purity ≥98% Biochemical and Physiological Mechanisms LY2812223 is a highly potent, functionally selective mGlu 2 receptor agonist with mGlu 2 binding affinity for mGlu 2 and mGlu 3 ( K i =144 nM and 156 nM, respectively). Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Product Description LY2812223 is a highly potent, functionally selective mGlu 2 receptor agonist with mGlu 2 binding affinity for mGlu 2 and mGlu 3 ( K i =144 nM and 156 nM, respectively)
Form:Solid
IC50& Target:mGluR2 144 nM (Ki) mGluR3 156 nM (Ki)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid INCHI InChI=1S/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/m1/s1 InChi Key YSOWRGMLMZQSBX-AVUIYAGVSA-N Canonical SMILES C1C(C2C(C2C1(C(=O)O)N)C(=O)O)SC3=NC=NN3 Isomeric SMILES C1[C@H]([C@H]2[C@@H]([C@H]2[C@@]1(C(=O)O)N)C(=O)O)SC3=NC=NN3 PubChem CID 53240406 MeSH Entry Terms 2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo(3.1.0)hexane-2,6-dicarboxylic acid;LY2812223 Molecular Weight 284.29
Chemical and Physical Properties Solubility H2O : 50 mg/mL (175.88 mM; Need ultrasonic) DMSO : 28.75 mg/mL (101.13 mM; Need ultrasonic)
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