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LY2886721 - ≥99%, high purity , CAS No.1262036-50-9, Inhibitor of beta-secretase 1
Potent and selective BACE-1 inhibitor
Basic Description Synonyms AS-56127 | MFCD22124078 | AC-33097 | (benzyloxycarbonyl)-glycine | BCP02507 | N-{3-[(4as,7as)-2-Amino-4a,5-Dihydro-4h-Furo[3,4-D][1,3]thiazin-7a(7h)-Yl]-4-Fluorophenyl}-5-Fluoropyridine-2-Carboxamide | J-522974 | N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydr Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Potent and selective BACE-1 inhibitor (IC 50 = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC 50 of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Di Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of beta-secretase 1 Product Description LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease. Phase 1/2.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide INCHI InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1 InChi Key NIDRNVHMMDAAIK-YPMLDQLKSA-N Canonical SMILES C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N Isomeric SMILES C1[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N PubChem CID 49837968 Molecular Weight 390.41
Chemical and Physical Properties Solubility DMSO 9 mg/mL (23.05 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)
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