LY334370 - 98%, high purity , CAS No.182563-08-2, Agonist of 5-HT 1A receptor;Agonist of 5-HT 1F receptor

Item Number
L344169
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SKUSizeAvailabilityPrice Qty
L344169-1mg
1mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
L344169-5mg
5mg
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$79.90
L344169-10mg
10mg
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$129.90
L344169-25mg
25mg
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$279.90
L344169-50mg
50mg
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$499.90
L344169-100mg
100mg
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$739.90

a selective SR-1F agonist

Basic Description

SynonymsBCP29131 | 4-fluoro-n-(3-(1-methyl-4-piperidinyl)-1h-indol-5-yl)benzamide | HMS3749M21 | MS-25442 | A935177 | Q6460422 | L000364 | 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-(2-ethoxyphenyl)-1,6-dihydro-1-methyl-3-propyl- | SCHEMBL6911508 | CS-0025021 | DTXSID4
Specifications & PurityMoligand™, ≥98%
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of 5-HT 1A receptor;Agonist of 5-HT 1F receptor
Product Description

LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.

Associated Targets(Human)

HTR1B Tclin 5-hydroxytryptamine receptor 1B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR1F Tclin 5-hydroxytryptamine receptor 1F (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR1A Tclin 5-hydroxytryptamine receptor 1A (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1D Tclin Serotonin 1d (5-HT1d) receptor (2897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1F Tclin Serotonin 1f (5-HT1f) receptor (245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1F Tclin 5-HT1A/5-HT1F (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1F Tclin 5-HT1B/5-HT1F (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide
INCHI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
InChi Key MDMJLMDBRQXOOI-UHFFFAOYSA-N
Canonical SMILES CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
Isomeric SMILES CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F
WGK Germany 3
Alternate CAS 182563-08-2
PubChem CID 5311258
MeSH Entry Terms 4-fluoro-N-(3-(1-methyl-4-piperidinyl)-1H-indol-5-yl)benzamide;LY 334370;LY-334370;LY334370
Molecular Weight 351.42

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
F2420163Certificate of AnalysisMar 14, 2024 L344169
F2420164Certificate of AnalysisMar 14, 2024 L344169
F2420165Certificate of AnalysisMar 14, 2024 L344169
F2420166Certificate of AnalysisMar 14, 2024 L344169
F2420167Certificate of AnalysisMar 14, 2024 L344169
F2420168Certificate of AnalysisMar 14, 2024 L344169
F2420169Certificate of AnalysisMar 14, 2024 L344169
F2420170Certificate of AnalysisMar 14, 2024 L344169
F2420171Certificate of AnalysisMar 14, 2024 L344169
F2420187Certificate of AnalysisMar 14, 2024 L344169
F2420188Certificate of AnalysisMar 14, 2024 L344169
F2420189Certificate of AnalysisMar 14, 2024 L344169

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Chemical and Physical Properties

SolubilitySoluble to 25 mM in water and to 25 mM in DMSO

Safety and Hazards(GHS)

Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

WGK Germany 3

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