The store will not work correctly when cookies are disabled.
LYS-006 , CAS No.1799681-85-8, Inhibitor of Leukotriene A 4 hydrolase
Basic Description
| Synonyms | LYS-006|1799681-85-8|LTA4H-IN-1|betaS-amino-5-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenyl]-2H-tetrazole-2-butanoic acid|LYS006|CHEMBL4852381|(3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid|59CF90960T|(3~{S})-3-a |
|---|
| Specifications & Purity | Moligand™ |
|---|
| Biochemical and Physiological Mechanisms | LYS-006 is a potent inhibitor of Leukotriene A4 hydrolase (LTA4H). LYS-006 can be used for the treatment of Hidradenitis Suppurativa. |
|---|
| Storage Temp | Store at -20°C |
|---|
| Shipped In | Ice chest + Ice pads |
|---|
| Grade | Moligand™ |
|---|
| Action Type | INHIBITOR |
|---|
| Mechanism of action | Inhibitor of Leukotriene A 4 hydrolase |
|---|
| Product Description | Information LYS-006 is a potent inhibitor of Leukotriene A4 hydrolase (LTA4H). LYS-006 can be used for the treatment of Hidradenitis Suppurativa. |
|---|
Names and Identifiers
| IUPAC Name | (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid |
|---|
| INCHI | InChI=1S/C16H14ClFN6O3/c17-10-5-13(18)16(20-7-10)27-12-3-1-9(2-4-12)15-21-23-24(22-15)8-11(19)6-14(25)26/h1-5,7,11H,6,8,19H2,(H,25,26)/t11-/m0/s1 |
|---|
| InChi Key | ZEGMEJVULDALSH-NSHDSACASA-N |
|---|
| Canonical SMILES | C1=CC(=CC=C1C2=NN(N=N2)CC(CC(=O)O)N)OC3=C(C=C(C=N3)Cl)F |
|---|
| Isomeric SMILES | C1=CC(=CC=C1C2=NN(N=N2)C[C@H](CC(=O)O)N)OC3=C(C=C(C=N3)Cl)F |
|---|
| PubChem CID | 118166560 |
|---|
| Molecular Weight | 392.77 |
|---|
References
| 1. Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, Wälchli R, Wolf R, Hinrichs J, Bergsdorf C et al.. (2021) Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.. J Med Chem, 64 (4): (1889-1903). [PMID:33592148] |
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
