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LYS-006 , CAS No.1799681-85-8, Inhibitor of Leukotriene A 4 hydrolase
Basic Description
| Synonyms | (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid | LYS006 | LYS-006 | 2H-TETRAZOLE-2-BUTANOIC ACID, .BETA.-AMINO-5-(4-((5-CHLORO-3-FLUORO-2-PYRIDINYL)OXY)PHENYL)-, (.BETA.S)- | RZE | SCHEMBL16827313 | HY-137298 | b |
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| Specifications & Purity | Moligand™ |
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| Biochemical and Physiological Mechanisms | LYS-006 is a potent inhibitor of Leukotriene A4 hydrolase (LTA4H). LYS-006 can be used for the treatment of Hidradenitis Suppurativa. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of Leukotriene A 4 hydrolase |
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| Product Description | Information LYS-006 is a potent inhibitor of Leukotriene A4 hydrolase (LTA4H). LYS-006 can be used for the treatment of Hidradenitis Suppurativa. |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (3S)-3-amino-4-[5-[4-(5-chloro-3-fluoropyridin-2-yl)oxyphenyl]tetrazol-2-yl]butanoic acid |
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| INCHI | InChI=1S/C16H14ClFN6O3/c17-10-5-13(18)16(20-7-10)27-12-3-1-9(2-4-12)15-21-23-24(22-15)8-11(19)6-14(25)26/h1-5,7,11H,6,8,19H2,(H,25,26)/t11-/m0/s1 |
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| InChi Key | ZEGMEJVULDALSH-NSHDSACASA-N |
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| Canonical SMILES | C1=CC(=CC=C1C2=NN(N=N2)CC(CC(=O)O)N)OC3=C(C=C(C=N3)Cl)F |
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| Isomeric SMILES | C1=CC(=CC=C1C2=NN(N=N2)C[C@H](CC(=O)O)N)OC3=C(C=C(C=N3)Cl)F |
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| PubChem CID | 118166560 |
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| Molecular Weight | 392.77 |
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References
| 1. Markert C, Thoma G, Srinivas H, Bollbuck B, Lüönd RM, Miltz W, Wälchli R, Wolf R, Hinrichs J, Bergsdorf C et al.. (2021) Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.. J Med Chem, 64 (4): (1889-1903). [PMID:33592148] [10.1021/op500134e] |
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