Lys-[Des-Arg9]Bradykinin, CAS No.71800-36-7, Agonist of B 1 receptor;Agonist of B 2 receptor

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    Item Number
    L286717
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    SKUSizeAvailabilityPrice Qty
    L286717-1mg
    1mg
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    Selective B1agonist

    Basic Description

    Product NameLys-[Des-Arg9]Bradykinin, CAS No.71800-36-7
    SynonymsLys-[Des-Arg9]Bradykinin | 71800-36-7 | des-Arg10-Kallidin | kallidin, des-Arg(10)- | [des-Arg10]kallidin | LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE | CHEMBL264100 | (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminome
    GradeMoligand™
    Specifications & PurityMoligand™
    Biochemical and Physiological MechanismsEndogenous potent and highly selective bradykinin B1receptor agonist (Kivalues are 0.12 and > 30000 nM at human B1and B2receptors respectively). Hypotensive agent that reduces peripheral vascular resistancein vivo. 16-fold more potent than[Des-Arg9]-Brady
    SequenceKRPPGFSPF
    Action TypeAGONIST
    Mechanism of actionAgonist of B 1 receptor;Agonist of B 2 receptor

    Associated Targets(Human)

    BDKRB2 Tclin B2 bradykinin receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    BDKRB1 Tchem B1 bradykinin receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Associated Targets(non-human)

    Bdkrb1 Bradykinin B1 receptor (77 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Product Specifications

    Storage TempStore at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS71800-36-7

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate NamesLys-[Des-Arg9]Bradykinin|71800-36-7|des-Arg10-Kallidin|kallidin, des-Arg(10)-|[des-Arg10]kallidin|LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE|CHEMBL264100|(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminome
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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