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M344 - ≥97%, high purity , CAS No.251456-60-7

  • ≥97%
Item Number
M125894
Grouped product items
SKUSizeAvailabilityPrice Qty
M125894-5mg
5mg
In stock
$58.90
M125894-20mg
20mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$212.90
M125894-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$238.90
M125894-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$860.90

HDAC inhibitor. Shows selectivity for HDAC6.

Basic Description

Synonyms251456-60-7|m344|4-(dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamide|M 344|Histone Deacetylase Inhibitor III|4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide|N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide|M-344|Benzamide, 4-(dimet
Specifications & Purity≥97%
Biochemical and Physiological MechanismsM344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial a
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
A potent HDAC inhibitor with IC50 of 100.

Associated Targets

HDAC6 Tclin Histone deacetylase 6 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX12 Tchem Arachidonate 12-lipoxygenase, 12S-type 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LTA4H Tchem Leukotriene A-4 hydrolase 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
INCHI InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
InChi Key MXWDSZWTBOCWBK-UHFFFAOYSA-N
Canonical SMILES CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO
Isomeric SMILES CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO
WGK Germany 3
PubChem CID 3994
Molecular Weight 307.39
Reaxy-Rn 8570090

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
L2308083Certificate of AnalysisDec 14, 2023 M125894
H1505068Certificate of AnalysisMar 16, 2023 M125894
K2313061Certificate of AnalysisMar 16, 2023 M125894

Chemical and Physical Properties

SolubilitySoluble in DMSO (62 mg/ml at 25 °C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
SensitivityHeat Sensitive
Melt Point(°C)152 °C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 8570090

Related Documents

Solution Calculators