Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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M125894-5mg | 5mg | In stock | $58.90 | |
M125894-20mg | 20mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $212.90 | |
M125894-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $238.90 | |
M125894-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $860.90 |
HDAC inhibitor. Shows selectivity for HDAC6.
Synonyms | 251456-60-7|m344|4-(dimethylamino)-n-[7-(hydroxyamino)-7-oxoheptyl]benzamide|M 344|Histone Deacetylase Inhibitor III|4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide|N-Hydroxy-7-(4-dimethylaminobenzoyl)aminoheptanamide|M-344|Benzamide, 4-(dimet |
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Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | M344 is a potent HDAC inhibitor (IC50 = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial a |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. |
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IUPAC Name | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide |
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INCHI | InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20) |
InChi Key | MXWDSZWTBOCWBK-UHFFFAOYSA-N |
Canonical SMILES | CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO |
Isomeric SMILES | CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO |
WGK Germany | 3 |
PubChem CID | 3994 |
Molecular Weight | 307.39 |
Reaxy-Rn | 8570090 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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L2308083 | Certificate of Analysis | Dec 14, 2023 | M125894 |
H1505068 | Certificate of Analysis | Mar 16, 2023 | M125894 |
K2313061 | Certificate of Analysis | Mar 16, 2023 | M125894 |
Solubility | Soluble in DMSO (62 mg/ml at 25 °C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C). |
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Sensitivity | Heat Sensitive |
Melt Point(°C) | 152 °C |
WGK Germany | 3 |
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Reaxy-Rn | 8570090 |