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Madecassic acid - 10mM in DMSO, high purity , CAS No.18449-41-7

10mM in DMSO

CAS#: 18449-41-7
Formula: C₃₀H₄₈O₆
Molecular Weight: 504.71
PubChem CID: 73412

Item Number

M422260

Grouped product items
SKU	Size	Availability	Price	Qty
M422260-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$266.90

Triterpenoid compound extracted from Centella asiatica with multiple biological activites

Basic Description

Synonyms	Madecassic acid\|Brahmic acid\|18449-41-7\|6beta-hydroxyasiatic acid\|UNII-M7O1N24J82\|ORISTRACT MDA\|CHEBI:73058\|M7O1N24J82\|NSC 88135\|CHEMBL481854\|NSC-88135\|(2alpha,3beta,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oic acid\|(1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Triterpenoid compound extracted from Centella asiatica with multiple biological activites. Non-competive cytochrome P450 (CYP) inhibitor (K i values are 34.1 and 49.7µM for CYP2C9 and CYP2D6 respectively). Inhibits LPS-induced NFκB activity.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets

PYGM Tchem Glycogen phosphorylase, muscle form 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN2 Tchem Tyrosine-protein phosphatase non-receptor type 2 0 Activities

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PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 0 Activities

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USP7 Tchem Ubiquitin carboxyl-terminal hydrolase 7 0 Activities

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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PRKAB2 Tchem 5'-AMP-activated protein kinase subunit beta-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

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SLC2A4 Tchem Solute carrier family 2, facilitated glucose transporter member 4 0 Activities

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RHO Tbio Rhodopsin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
INCHI	InChI=1S/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30+/m1/s1
InChi Key	PRAUVHZJPXOEIF-AOLYGAPISA-N
Canonical SMILES	CC1CCC2(CCC3(C(=CCC4C3(CC(C5C4(CC(C(C5(C)CO)O)O)C)O)C)C2C1C)C)C(=O)O
Isomeric SMILES	C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O
PubChem CID	73412
Molecular Weight	504.71

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