MAK683 - 99%, high purity , CAS No.1951408-58-4, Allosteric modulator of embryonic ectoderm development

Item Number

M414309

• Synonyms: A16922 | 1951408-58-4 | D93894 | BDBM291687 | EED inhibitor-1 | UNII-4K446Z8N51 | 4K446Z8N51 | N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | AC-30344 | MAK683 | MAK-683 | example 2 [W
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of embryonic ectoderm development

Product Description

Information

MAK683 MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED) . MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.

Targets

EED (ELISA assay); EED (EED Alphascreen binding assay); EED (LC-MS assay) 26 nM; 59 nM; 89 nM

In vitro

MAK-683 binds to EED and disrupts the PRC2 complex. Cell viability is not significantly affected and the levels of H3K27me3 are decreased. A significant increase in the percentage of mature PCs after MAK-683 treatment in association with a higher CD38 expression is also identified.

Cell Research(from reference)

Cell lines：MBCs 

Concentrations：2\u2009µM 

Incubation Time：4 days, 3 days