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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Basic Description
| Synonyms | Mangiferin | 4773-96-0 | Chinonin | Alpizarin | Hedysarid | Chinomin | Aphloiol | Alpizarine | Shamimin | UNII-1M84LD0UMD | 1M84LD0UMD | CHEBI:6682 | 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one | NSC 248870 | (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthe |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
Associated Targets(Human)
AKR1B1 Tclin Aldose reductase (1404 Activities)
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
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U2OS (164939 Activities)
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NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)
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Associated Targets(non-human)
NA Neuraminidase (1107 Activities)
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Gusb Beta-glucuronidase (17 Activities)
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Mmp9 Matrix metalloproteinase 9 (38 Activities)
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Plasmodium falciparum (966862 Activities)
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Rattus norvegicus (775804 Activities)
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Human alphaherpesvirus 1 (11089 Activities)
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3T3-L1 (3664 Activities)
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BHK-21 (725 Activities)
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Vero (26788 Activities)
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BV-2 (3710 Activities)
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Genome polyprotein (620 Activities)
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rep Replicase polyprotein 1ab (378 Activities)
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nanH Sialidase (337 Activities)
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Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (75 Activities)
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Danio rerio (3092 Activities)
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Plasma (328 Activities)
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SARS-CoV-2 (38078 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one |
|---|---|
| INCHI | InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1 |
| InChi Key | AEDDIBAIWPIIBD-ZJKJAXBQSA-N |
| Canonical SMILES | C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O |
| Isomeric SMILES | C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O |
| PubChem CID | 5281647 |
| Molecular Weight | 422.34 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Melt Point(°C) | 270 °C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
| Hazard Statements | H302:Harmful if swallowed |
| Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
Related Documents
Citations of This Product
| 1. Wanran Huang, Yanni Wang, Wei Huang. (2023) Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. NEUROSCIENCE LETTERS, (137608). [PMID:38142926] [10.1016/j.neulet.2023.137608] |
| 2. Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu. (2023) Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense. ACS Chemical Neuroscience, 14 (8): (1379–1387). [PMID:37036451] [10.1021/acschemneuro.2c00458] |
| 3. Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang. (2022) A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing. JOURNAL OF CONTROLLED RELEASE, 341 (147). [PMID:34813880] [10.1016/j.jconrel.2021.11.027] |
| 4. Yunbo Li, Benguo Liu, Mengmeng Yu, Sheng Geng. (2021) High-efficiency formation mechanism of mangiferin/γ-cyclodextrin complex. FOOD SCIENCE AND TECHNOLOGY RESEARCH, [PMID:] [10.3136/fstr.27.735] |
References
| 1. Wanran Huang, Yanni Wang, Wei Huang. (2023) Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. NEUROSCIENCE LETTERS, (137608). [PMID:38142926] [10.1016/j.neulet.2023.137608] |
| 2. Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu. (2023) Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense. ACS Chemical Neuroscience, 14 (8): (1379–1387). [PMID:37036451] [10.1021/acschemneuro.2c00458] |
| 3. Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang. (2022) A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing. JOURNAL OF CONTROLLED RELEASE, 341 (147). [PMID:34813880] [10.1016/j.jconrel.2021.11.027] |
| 4. Yunbo Li, Benguo Liu, Mengmeng Yu, Sheng Geng. (2021) High-efficiency formation mechanism of mangiferin/γ-cyclodextrin complex. FOOD SCIENCE AND TECHNOLOGY RESEARCH, [PMID:] [10.3136/fstr.27.735] |